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Primary bulbar conjunctival basal cell carcinoma: A clinical-pathologic report and literature review.

التفاصيل البيبلوغرافية
العنوان: Primary bulbar conjunctival basal cell carcinoma: A clinical-pathologic report and literature review.
المؤلفون: Lin RZ; Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA., Hong AR; Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA., Harocopos GJ; Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.; Department of Pathology & Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA.
المصدر: American journal of ophthalmology case reports [Am J Ophthalmol Case Rep] 2023 Jul 27; Vol. 32, pp. 101906. Date of Electronic Publication: 2023 Jul 27 (Print Publication: 2023).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101679941 Publication Model: eCollection Cited Medium: Internet ISSN: 2451-9936 (Electronic) Linking ISSN: 24519936 NLM ISO Abbreviation: Am J Ophthalmol Case Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Atlanta] : Elsevier, Inc. [2016]-
مستخلص: Purpose: To enhance the characterization of primary bulbar conjunctival basal cell carcinoma (BCC) clinically and histologically, via report of a case and review of the relevant medical literature.
Observations: We report the case of a 73-year-old man with no history of skin cancer who presented with a bulbar conjunctival nodule without connection to the eyelid or caruncle, originally thought to represent a pyogenic granuloma. After one month without improvement on topical prednisolone, excisional biopsy was performed, with routine histopathology and immunohistochemistry. The tumor was found histologically to be primary conjunctival BCC. Immunostaining exhibited negative Ber-EP4 and S100, mostly negative CK7 and EMA, and positive p63. Margins were negative, and the patient had no recurrence six months after excision.
Conclusions and Importance: Primary conjunctival BCC must be considered in the differential diagnosis of a conjunctival lesion which may initially appear benign but does not behave as expected clinically. The location of the tumor in the case presented here refutes a prior postulate that primary conjunctival BCC arises from basal adnexal epithelium in the caruncle. Of the immunohistochemical findings, only the Ber-EP4 result differed from the typical immunostaining profile of cutaneous BCC. Further study is needed to determine the frequency of Ber-EP4 positivity in primary conjunctival BCC.
Competing Interests: The authors have no conflict of interest.
(© 2023 The Authors.)
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فهرسة مساهمة: Keywords: Basal cell carcinoma; Bulbar conjunctiva; Conjunctival tumor; Histopathology; Immunohistochemistry; Oncology
تواريخ الأحداث: Date Created: 20230810 Latest Revision: 20230811
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10407625
DOI: 10.1016/j.ajoc.2023.101906
PMID: 37560558
قاعدة البيانات: MEDLINE
الوصف
تدمد:2451-9936
DOI:10.1016/j.ajoc.2023.101906