دورية أكاديمية
أعرض في EDS

Age-dependent transcriptomic profiles of leukocytes in pediatric population.

التفاصيل البيبلوغرافية
العنوان: Age-dependent transcriptomic profiles of leukocytes in pediatric population.
المؤلفون: Koutsogiannaki S; Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, MA, 02115, United States; Department of Anaesthesia and Immunology, Harvard Medical School, Boston, MA, 02115, United States; Broad Institute of MIT and Harvard, Cambridge, MA, 02141, United States., Kim S; Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, MA, 02115, United States., Yuki K; Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, MA, 02115, United States; Department of Anaesthesia and Immunology, Harvard Medical School, Boston, MA, 02115, United States; Broad Institute of MIT and Harvard, Cambridge, MA, 02141, United States. Electronic address: koichi.yuki@childrens.harvard.edu.
المصدر: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2023 Oct; Vol. 255, pp. 109728. Date of Electronic Publication: 2023 Aug 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Orlando, FL : Academic Press, c1999-
مواضيع طبية MeSH: Leukocytes, Mononuclear* , Transcriptome*, Infant ; Infant, Newborn ; Humans ; Child ; Child, Preschool ; Leukocytes ; Immunity, Innate ; T-Lymphocytes
مستخلص: Immunity at birth is considered immature. Following birth, our immune function is considered to grow and reach maturation over time. To obtain granular information of leukocyte functions and transcriptomic profiles in pediatric cohort, we examined leukocyte profiles in infants, preschool and school children using single cell RNA sequencing of their peripheral blood mononuclear cells (PBMCs). Monocytes and natural killer (NK) cells showed immaturity in infants. Their innate and adaptive immunity was developed by preschool age. Adaptive immune cells showed different maturation patterns. CD4, CD8 naïve T cells and plasma cells continued to mature untill school age. In CD8 naïve T cells, innate immunity was upregulated in infants, in support of our knowledge that they manifests more innate cell-like phenotype soon after birth. Many signaling pathways have been differentially up- and/or down-regulated in infants, preschool and school children. Their contribution to the development of the immune system needs to be delineated.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
References: Protein Cell. 2020 Oct;11(10):740-770. (PMID: 32780218)
Front Immunol. 2022 Jul 12;13:873232. (PMID: 35903094)
Int J Cancer. 1975 Aug 15;16(2):216-29. (PMID: 50294)
J Innate Immun. 2011;3(3):280-8. (PMID: 21411972)
Front Immunol. 2021 Aug 18;12:684119. (PMID: 34484182)
Blood. 2008 Sep 1;112(5):1570-80. (PMID: 18725575)
PLoS One. 2016 Sep 09;11(9):e0162242. (PMID: 27610624)
Cell Rep. 2017 Aug 22;20(8):1830-1843. (PMID: 28834747)
Front Immunol. 2020 Jun 04;11:1070. (PMID: 32582174)
Mol Cell Biol. 2002 Feb;22(4):1001-15. (PMID: 11809793)
J Immunol. 2019 Jan 1;202(1):69-78. (PMID: 30478091)
Nucleic Acids Res. 2022 Jul 5;50(W1):W216-W221. (PMID: 35325185)
Front Immunol. 2019 Aug 30;10:2035. (PMID: 31543877)
Immunol Res. 2014 Aug;59(1-3):12-22. (PMID: 24847763)
PLoS One. 2014 Dec 10;9(12):e114604. (PMID: 25494178)
Crit Rev Immunol. 2016;36(2):131-147. (PMID: 27910764)
Am J Dis Child. 1967 Jun;113(6):633-8. (PMID: 4165214)
Chin Med J (Engl). 2020 Aug 20;133(16):1900-1907. (PMID: 32826452)
Cytokine. 2015 Aug;74(2):318-26. (PMID: 25742773)
Cells. 2021 Feb 04;10(2):. (PMID: 33557010)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Cell. 2009 Oct 30;139(3):573-86. (PMID: 19879843)
J Allergy Clin Immunol. 2018 Jun;141(6):2208-2219.e16. (PMID: 29505809)
Immunity. 2012 Nov 16;37(5):771-83. (PMID: 23159225)
Curr Opin Immunol. 2014 Jun;28:77-83. (PMID: 24637161)
J Immunol. 2008 Sep 15;181(6):3777-83. (PMID: 18768830)
Immune Netw. 2017 Oct;17(5):298-306. (PMID: 29093651)
Nat Immunol. 2019 Apr;20(4):458-470. (PMID: 30890796)
Blood. 2005 May 15;105(10):3965-71. (PMID: 15687242)
Oncogene. 2003 Mar 13;22(10):1536-45. (PMID: 12629517)
PLoS One. 2016 Nov 28;11(11):e0166633. (PMID: 27893767)
Nat Rev Immunol. 2008 May;8(5):372-9. (PMID: 18362948)
Nat Rev Immunol. 2012 Apr 20;12(5):325-38. (PMID: 22517423)
Nat Med. 2009 Jul;15(7):808-13. (PMID: 19525962)
Sci Rep. 2018 Jan 22;8(1):1327. (PMID: 29358580)
Pediatr Res. 1990 Oct;28(4):316-22. (PMID: 1700360)
J Immunol. 2010 Mar 1;184(5):2289-96. (PMID: 20139273)
Front Pediatr. 2017 Feb 21;5:15. (PMID: 28271056)
J Leukoc Biol. 2019 Nov;106(5):1051-1061. (PMID: 31260598)
Nat Immunol. 2020 Nov;21(11):1408-1420. (PMID: 32868930)
J Lipid Res. 2019 Apr;60(4):721-727. (PMID: 30782961)
PLoS Pathog. 2021 Jul 6;17(7):e1009721. (PMID: 34228753)
Clin Dev Immunol. 2012;2012:925135. (PMID: 22474485)
Leukemia. 2019 May;33(5):1063-1075. (PMID: 30770859)
Immunity. 2006 Oct;25(4):545-57. (PMID: 17000121)
Cell Mol Immunol. 2018 Dec;15(12):1003-1009. (PMID: 29568120)
Sci Rep. 2020 Oct 20;10(1):17836. (PMID: 33082466)
J Immunol. 2005 Feb 1;174(3):1153-8. (PMID: 15661867)
Ann Clin Lab Sci. 2015 Summer;45(4):403-13. (PMID: 26275691)
J Thromb Haemost. 2019 Feb;17(2):403-414. (PMID: 30456926)
Annu Rev Virol. 2019 Sep 29;6(1):567-584. (PMID: 31283436)
Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):. (PMID: 34686603)
Eur J Immunol. 1999 Jul;29(7):2241-7. (PMID: 10427987)
Cell Rep. 2013 Nov 27;5(4):1022-35. (PMID: 24239354)
J Exp Med. 2017 Jul 3;214(7):1913-1923. (PMID: 28606987)
J Immunol. 2008 Sep 1;181(5):3373-83. (PMID: 18714009)
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 May 10;41(5):638-641. (PMID: 32164400)
PLoS One. 2017 Aug 2;12(8):e0181134. (PMID: 28767726)
Front Immunol. 2012 Aug 13;3:245. (PMID: 22905034)
J Biol Chem. 1990 Sep 15;265(26):15823-31. (PMID: 2394750)
Front Immunol. 2019 Nov 22;10:2768. (PMID: 31824518)
Genes Dev. 2016 Jan 1;30(1):1-17. (PMID: 26728553)
Cell. 2002 Apr;109 Suppl:S13-9. (PMID: 11983149)
Blood. 2014 Mar 20;123(12):1897-904. (PMID: 24518760)
Front Immunol. 2018 Jul 30;9:1726. (PMID: 30105020)
Cancer Res. 1990 Jan 15;50(2):222-6. (PMID: 2153047)
معلومات مُعتمدة: R21 HD099194 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: Maturation; Pediatric immune system; Single cell RNA sequencing
تواريخ الأحداث: Date Created: 20230810 Date Completed: 20231002 Latest Revision: 20231004
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10543464
DOI: 10.1016/j.clim.2023.109728
PMID: 37562722
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-7035
DOI:10.1016/j.clim.2023.109728