دورية أكاديمية
Dynamics of Podospora anserina Genome Evolution in a Long-Term Experiment.
| العنوان: | Dynamics of Podospora anserina Genome Evolution in a Long-Term Experiment. |
|---|---|
| المؤلفون: | Kudryavtseva OA; Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Gerasimov ES; Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Glagoleva ES; Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Gasparyan AA; Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Agroskin SM; Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Belozersky MA; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Dunaevsky YE; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Jul 27; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مستخلص: | The Podospora anserina long-term evolution experiment (PaLTEE) is the only running filamentous fungus study, which is still going on. The aim of our work is to trace the evolutionary dynamics of the accumulation of mutations in the genomes of eight haploid populations of P. anserina. The results of the genome-wide analysis of all of the lineages, performed 8 years after the start of the PaLTEE, are presented. Data analysis detected 312 single nucleotide polymorphisms (SNPs) and 39 short insertion-deletion mutations (indels) in total. There was a clear trend towards a linear increase in the number of SNPs depending on the experiment duration. Among 312 SNPs, 153 were fixed in the coding regions of P. anserina genome. Relatively few synonymous mutations were found, exactly 38; 42 were classified as nonsense mutations; 72 were assigned to missense mutations. In addition, 21 out of 39 indels identified were also localized in coding regions. Here, we also report the detection of parallel evolution at the paralog level in the P. anserina model system. Parallelism in evolution at the level of protein functions also occurs. The latter is especially true for various transcription factors, which may indicate selection leading to optimization of the wide range of cellular processes under experimental conditions. |
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| معلومات مُعتمدة: | 23-24-00318 Russian Science Foundation |
| فهرسة مساهمة: | Keywords: Podospora anserina; experimental evolution; long-term experiment; parallel evolution |
| تواريخ الأحداث: | Date Created: 20230812 Latest Revision: 20230814 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10418817 |
| DOI: | 10.3390/ijms241512009 |
| PMID: | 37569385 |
| قاعدة البيانات: | MEDLINE |
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