دورية أكاديمية
أعرض في EDS

Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand-Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation.

التفاصيل البيبلوغرافية
العنوان: Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand-Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation.
المؤلفون: Akter T; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Bulbul MRH; Institute for Developing Science and Health Initiatives, ideSHi, Dhaka 1216, Bangladesh., Sama-Ae I; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand., Azadi MA; Department of Zoology, University of Chittagong, Chittagong 4331, Bangladesh., Nira KN; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Al-Araby SQ; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Deen JI; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Rafi MKJ; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Saha S; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh., Ezaj MMA; Department of Genetic Engineering and Biotechnology, University of Chittagong, Chittagong 4331, Bangladesh., Rahman MA; Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
المصدر: Nutrients [Nutrients] 2023 Jul 31; Vol. 15 (15). Date of Electronic Publication: 2023 Jul 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Tamarindus*/chemistry , Hypertension*/drug therapy, Rats ; Animals ; Antioxidants/pharmacology ; Sitosterols ; Antihypertensive Agents/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Molecular Dynamics Simulation ; Molecular Docking Simulation ; Ligands ; Phylogeny ; Guanylate Cyclase
مستخلص: This research investigated the antihypertensive effects of tamarind products and compared their potentials based on an animal model's data verified by molecular docking, multitarget interactions, and dynamic simulation assays. GC-MS-characterized tamarind products were administered to cholesterol-induced hypertensive albino rat models. The two-week-intervened animals were dissected to collect their serum and organs and respectively subjected to analyses of their hypertension-linked markers and tissue architectures. The lead biometabolites of tamarinds interacted with eight target receptors in the molecular docking and dynamic simulation studies and with multitarget in the network pharmacological analyses. The results show that the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), C-reactive protein (CRP), troponin I, and lipid profiles were maximally reinstated by the phenolic-enriched ripened sour tamarind extract compared to the sweet one, but the seed extracts had a smaller influence. Among the tamarind's biometabolites, ϒ-sitosterol was found to be the best ligand to interact with the guanylate cyclase receptor, displaying the best drug-likeliness with the highest binding energy, -9.3 Kcal. A multitargeted interaction-based degree algorithm and a phylogenetic tree of pathways showed that the NR3C1 , REN , PPARG , and CYP11B1 hub genes were consistently modulated by ϒ-sitosterol to reduce hypertension and related risk factors. The dynamic simulation study showed that the P-RMSD values of ϒ-sitosterol-guanylate cyclase were stable between 75.00 and 100.00 ns at the binding pocket. The findings demonstrate that ripened sour tamarind extract may be a prospective antihypertensive nutraceutical or supplement target affirmed through advanced preclinical and clinical studies.
References: Endocrinol Metab Clin North Am. 2011 Jun;40(2):433-49, ix-x. (PMID: 21565677)
Sci Rep. 2018 Jan 16;8(1):862. (PMID: 29339763)
Nutrients. 2018 Jul 21;10(7):. (PMID: 30037080)
FEBS Lett. 1997 Nov 24;418(1-2):152-6. (PMID: 9414116)
Biol Pharm Bull. 2006 Apr;29(4):760-5. (PMID: 16595914)
Eur J Gastroenterol Hepatol. 2011 Nov;23(11):1011-7. (PMID: 21915061)
J Endocrinol Invest. 2015 Oct;38(10):1039-46. (PMID: 26134064)
Food Chem Toxicol. 2004 Aug;42(8):1237-44. (PMID: 15207373)
Gen Pharmacol. 1993 Jul;24(4):857-62. (PMID: 8224739)
Curr Top Med Chem. 2021;21(8):686-695. (PMID: 33280598)
Food Chem. 2013 Aug 15;139(1-4):196-202. (PMID: 23561096)
Free Radic Res. 2011 May;45(5):611-9. (PMID: 21405989)
Braz J Med Biol Res. 2016 Dec 12;49(12):e5646. (PMID: 27982281)
Circulation. 2004 Jun 15;109(23 Suppl 1):III8-14. (PMID: 15198960)
Med Arch. 2015 Aug;69(4):251-5. (PMID: 26543313)
J Renin Angiotensin Aldosterone Syst. 2014 Jun;15(2):150-5. (PMID: 23204185)
Food Chem Toxicol. 2007 Jul;45(7):1216-23. (PMID: 17336438)
Nutrients. 2019 Mar 19;11(3):. (PMID: 30893845)
Crit Rev Food Sci Nutr. 2023;63(14):2093-2118. (PMID: 34553653)
Am J Physiol Renal Physiol. 2020 Apr 1;318(4):F888-F900. (PMID: 32036698)
J Med Chem. 2002 Jun 6;45(12):2615-23. (PMID: 12036371)
Exp Physiol. 1997 Mar;82(2):291-5. (PMID: 9129943)
Endocrine. 2018 Jul;61(1):125-133. (PMID: 29611097)
Pharmacol Rep. 2005;57 Suppl:97-107. (PMID: 16415490)
PLoS One. 2015 May 01;10(5):e0121538. (PMID: 25933112)
Food Chem Toxicol. 2006 Jun;44(6):810-8. (PMID: 16330140)
Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1232-8. (PMID: 15317677)
Biol Reprod. 2015 Aug;93(2):38. (PMID: 26085523)
Int J Mol Sci. 2019 Sep 04;20(18):. (PMID: 31487867)
J Hum Hypertens. 2023 Aug;37(8):619-625. (PMID: 36335169)
Nat Chem Biol. 2008 Nov;4(11):682-90. (PMID: 18936753)
BMC Cardiovasc Disord. 2020 Mar 11;20(1):128. (PMID: 32160872)
Anal Biochem. 1999 May 1;269(2):337-41. (PMID: 10222007)
Curr Hypertens Rep. 2014 Jun;16(6):432. (PMID: 24788870)
Evid Based Complement Alternat Med. 2021 Nov 16;2021:6704798. (PMID: 34824593)
J Ethnopharmacol. 2003 Nov;89(1):61-6. (PMID: 14522433)
Indian Pediatr. 2010 Nov;47(11):965-7. (PMID: 20453266)
Front Mol Neurosci. 2014 May 19;7:38. (PMID: 24904270)
Curr Opin Investig Drugs. 2010 Oct;11(10):1107-15. (PMID: 20872313)
Bioinformatics. 2019 Mar 15;35(6):1067-1069. (PMID: 30165565)
BMC Pharmacol. 2003 Dec 20;3:16. (PMID: 14687418)
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26. (PMID: 11259830)
Am J Respir Cell Mol Biol. 2020 Nov;63(5):652-664. (PMID: 32692928)
Sci Rep. 2016 Oct 07;6:34984. (PMID: 27713574)
J Hypertens. 2003 Dec;21(12):2281-6. (PMID: 14654748)
Biochimie. 2006 Mar-Apr;88(3-4):359-65. (PMID: 16330143)
Arch Intern Med. 1983 Dec;143(12):2291-4. (PMID: 6360063)
J Hypertens. 2011 Mar;29(3):492-500. (PMID: 21178785)
Nucleic Acids Res. 2015 Jul 1;43(W1):W436-42. (PMID: 25956651)
Clin Exp Hypertens. 2017;39(2):175-182. (PMID: 28287883)
Eur Heart J. 2014 Sep 1;35(33):2242-8a. (PMID: 24796340)
Sci Transl Med. 2013 Mar 6;5(175):175ra29. (PMID: 23467560)
Medicina (Kaunas). 2019 Jul 23;55(7):. (PMID: 31340610)
Hepatology. 2008 Apr;47(4):1167-77. (PMID: 18311774)
Med Sci Monit. 2017 May 24;23:2488-2499. (PMID: 28537227)
J Appl Physiol. 1970 Feb;28(2):234-6. (PMID: 5413312)
Hepatology. 2001 Oct;34(4 Pt 1):745-50. (PMID: 11584371)
Pharmacol Res. 2021 Mar;165:105329. (PMID: 33465473)
J Hum Hypertens. 2014 Jul;28(7):410-5. (PMID: 24226100)
J Agric Food Chem. 2011 Aug 24;59(16):8985-93. (PMID: 21751816)
Lancet. 1977 Jul 16;2(8029):111-4. (PMID: 69196)
Molecules. 2023 Mar 07;28(6):. (PMID: 36985395)
Hepatology. 2004 Nov;40(5):1222-5. (PMID: 15382153)
JAMA. 2010 Dec 8;304(22):2503-12. (PMID: 21139111)
Thorax. 2018 Jun;73(6):519-529. (PMID: 29440315)
Biosci Rep. 2019 Feb 27;39(2):. (PMID: 30777927)
Biology (Basel). 2021 May 01;10(5):. (PMID: 34062724)
J Am Coll Cardiol. 2007 Aug 21;50(8):760-7. (PMID: 17707181)
Food Res Int. 2022 Feb;152:110871. (PMID: 35181119)
Hypertension. 2004 Sep;44(3):248-52. (PMID: 15262903)
Korean Circ J. 2016 Mar;46(2):135-44. (PMID: 27014342)
Aliment Pharmacol Ther. 2011 Aug;34(3):274-85. (PMID: 21623852)
Curr Opin Pharmacol. 2015 Apr;21:7-13. (PMID: 25500206)
JAMA Ophthalmol. 2017 May 1;135(5):446-451. (PMID: 28334414)
Front Mol Biosci. 2021 Jan 07;7:627767. (PMID: 33490110)
ScientificWorldJournal. 2022 Jul 31;2022:8924023. (PMID: 35958801)
J Am Diet Assoc. 2011 Aug;111(8):1173-81. (PMID: 21802563)
Nature. 1990 Oct 18;347(6294):631-9. (PMID: 2215695)
J Physiol Biochem. 2014 Jun;70(2):629-37. (PMID: 24610672)
Annu Rev Biochem. 2012;81:533-59. (PMID: 22404633)
Food Chem Toxicol. 2018 Feb;112:495-506. (PMID: 28843597)
BMJ Open. 2019 May 1;9(4):e026777. (PMID: 31048445)
J Med Chem. 2011 Jun 23;54(12):4219-33. (PMID: 21557540)
J Mol Graph Model. 2018 Jan;79:103-117. (PMID: 29156380)
فهرسة مساهمة: Keywords: Tamarindus indica; antihypertensive; dynamic simulation; gamma-sitosterol; network pharmacology; troponin I
المشرفين على المادة: 0 (Antioxidants)
0 (Sitosterols)
0 (Antihypertensive Agents)
0 (Plant Extracts)
0 (Ligands)
EC 4.6.1.2 (Guanylate Cyclase)
تواريخ الأحداث: Date Created: 20230812 Date Completed: 20230814 Latest Revision: 20230814
رمز التحديث: 20230814
مُعرف محوري في PubMed: PMC10420995
DOI: 10.3390/nu15153402
PMID: 37571339
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu15153402