Implications of Vascular Depression for Successful Cognitive Aging in HIV disease.
| العنوان: | Implications of Vascular Depression for Successful Cognitive Aging in HIV disease. |
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| المؤلفون: | Mustafa AI; University of Houston., Beltran-Najera I; University of Houston., Evans D; University of Houston., Bartlett A; Georgia State University., Dotson VM; Georgia State University., Woods SP; University of Houston. |
| المصدر: | Research square [Res Sq] 2023 Jul 31. Date of Electronic Publication: 2023 Jul 31. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE |
| مستخلص: | Introduction: Although older adults with HIV are at high risk for mild neurocognitive disorders, a subset experience successful cognitive aging (SCA). HIV is associated with an increased risk of vascular depression (VasDep), which can affect cognitive and daily functioning. The current study examined whether VasDep impedes SCA among older adults with HIV. Methods: 136 persons with HIV aged 50 years and older were classified as either SCA+ (n=37) or SCA- (n=99) based on a battery of demographically adjusted neurocognitive tests and self-reported cognitive symptoms. Participants were also stratified on the presence of vascular disease (e.g., hypertension) and current depression as determined by the Composite International Diagnostic Interview and the Depression/Dejection scale of the Profile of Mood States. Results: A Cochran-Armitage test revealed a significant additive effect of vascular disease and depression on SCA in this sample of older adults with HIV ( z =4.13, p <.0001). Individuals with VasDep had the lowest frequency of SCA+ (0%), which differed significantly from the group with only vascular disease (30%, OR=0.04, CI=0.002,0.68)) and the group with neither vascular disease nor depression (47% OR =0.02, CI=0.33,0.001). Findings were not confounded by demographics, HIV disease severity, or other psychiatric and medical factors ( ps >.05). Discussion: These data suggest that presence of VasDep may be a barrier to SCA in older adults with HIV disease. Prospective, longitudinal studies with neuroimaging-based operationalizations of VasDep are needed to further clarify this risk factor's role in the maintenance of cognitive and brain health in persons with HIV disease. |
| التعليقات: | Update in: J Neurovirol. 2024 Mar 28;:. (PMID: 38546936) |
| معلومات مُعتمدة: | R21 MH098607 United States MH NIMH NIH HHS; R01 MH073419 United States MH NIMH NIH HHS; U19 AG065169 United States AG NIA NIH HHS; P30 MH062512 United States MH NIMH NIH HHS; U19 AG073172 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: cardiovascular; geropsychology; infectious disease; mood disorder; neurocognitive disorder; positive psychology |
| تواريخ الأحداث: | Date Created: 20230814 Latest Revision: 20240408 |
| رمز التحديث: | 20240408 |
| مُعرف محوري في PubMed: | PMC10418560 |
| DOI: | 10.21203/rs.3.rs-3154022/v1 |
| PMID: | 37577512 |
| قاعدة البيانات: | MEDLINE |
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