دورية أكاديمية
أعرض في EDS

Effects of body mass index on the immune response within the first days after major stroke in humans.

التفاصيل البيبلوغرافية
العنوان: Effects of body mass index on the immune response within the first days after major stroke in humans.
المؤلفون: Ruhnau J; Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany. johanna.ruhnau@uni-greifswald.de., Heuer C; Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany., Witt C; Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany., Ceesay S; Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany., Schulze J; Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany., Gross S; Partner site Greifswald, German Centre for Cardiovascular Research (DZHK), Greifswald, Germany., Waize M; Department of Mathematics and Informatics, University Medicine Greifswald, Greifswald, Germany., Kromrey ML; Department of Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Kühn JP; Department of Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.; Institute and Policlinic of Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus, Dresden, Germany., Langner S; Department of Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Grunwald U; Internal Medicine C, Hematology and Oncology, University Medicine Greifswald, Greifswald, Germany., Bröker BM; Department of Immunology, University Medicine Greifswald, Greifswald, Germany., Petersmann A; Department of Clinical Diagnostics, University Oldenburg, Oldenburg, Germany., Steveling A; Department of Endocrinology, University Medicine Greifswald, Greifswald, Germany., Dressel A; Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany.; Department of Neurology, Carl-Thiem Klinikum, Cottbus, Germany., Vogelgesang A; Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany. antje.vogelgesang@uni-greifswald.de.
المصدر: Neurological research and practice [Neurol Res Pract] 2023 Aug 17; Vol. 5 (1), pp. 42. Date of Electronic Publication: 2023 Aug 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMC Country of Publication: England NLM ID: 101767802 Publication Model: Electronic Cited Medium: Internet ISSN: 2524-3489 (Electronic) Linking ISSN: 25243489 NLM ISO Abbreviation: Neurol Res Pract Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMC, [2019]-
مستخلص: Introduction: Immunological alterations associated with increased susceptibility to infection are an essential aspect of stroke pathophysiology. Several immunological functions of adipose tissue are altered by obesity and are accompanied by chronic immune activation. The purpose of this study was to examine immune function (monocytes, granulocytes, cytokines) as a function of body mass index (BMI: 1st group: 25; 2nd group: 25 BMI 30; 3rd group: 30) and changes in body weight post stroke.
Method: Fat status was assessed using standardized weight measurements on days 1, 2, 3, 4, 5, and 7 after ischemic stroke in a cohort of 40 stroke patients and 16 control patients. Liver fat and visceral fat were assessed by MRI on day 1 or 2 [I] and on day 5 or 7 [II]. Leukocyte subpopulations in peripheral blood, cytokines, chemokines, and adipokine concentrations in sera were quantified. In a second cohort (stroke and control group, n = 17), multiple regression analysis was used to identify correlations between BMI and monocyte and granulocyte subpopulations.
Results: Weight and fat loss occurred from the day of admission to day 1 after stroke without further reduction in the postischemic course. No significant changes in liver or visceral fat were observed between MRI I and MRI II. BMI was inversely associated with IL-6 levels, while proinflammatory cytokines such as eotaxin, IFN-β, IFN -γ and TNF-α were upregulated when BMI increased. The numbers of anti-inflammatory CD14 + CD16 + monocytes and CD16 + CD62L - granulocytes were reduced in patients with higher BMI values, while that of proinflammatory CD16 dim CD62L + granulocytes was increased.
Conclusion: A small weight loss in stroke patients was detectable. The data demonstrate a positive correlation between BMI and a proinflammatory poststroke immune response. This provides a potential link to how obesity may affect the clinical outcome of stroke patients.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Obesity; Poststroke immune modulation; Stroke
تواريخ الأحداث: Date Created: 20230816 Latest Revision: 20230819
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10433619
DOI: 10.1186/s42466-023-00269-1
PMID: 37587512
قاعدة البيانات: MEDLINE
الوصف
تدمد:2524-3489
DOI:10.1186/s42466-023-00269-1