دورية أكاديمية
Risk Factors for Perinatal Transmission of Hepatitis C Virus.
| العنوان: | Risk Factors for Perinatal Transmission of Hepatitis C Virus. |
|---|---|
| المؤلفون: | Prasad M; Departments of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, University of Texas Medical Branch, Galveston, Texas, Brown University, Providence, Rhode Island, MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio, University of Alabama at Birmingham, Birmingham, Alabama, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, University of Utah Health Sciences Center, Salt Lake City, Utah, Columbia University, New York, New York, Boston Medical Center, Boston, Massachusetts, University of Pittsburgh, Pittsburgh, Pennsylvania, Duke University, Durham, North Carolina, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas, Northwestern University, Chicago, Illinois, Stanford University, Stanford, California, University of Texas Southwestern Medical Center, Dallas, Texas, University of Pennsylvania, Philadelphia, Pennsylvania, University of Florida Center for HIV/AIDS Research, Education and Service, Jacksonville, Florida, San Juan Hospital, San Juan, Puerto Rico, Children's Diagnostic and Treatment Center, Fort Lauderdale, Florida, Jacobi Medical Center, Bronx, New York, University of Southern California, Los Angeles, California, SUNY Stony Brook, Stony Brook, New York, and Washington University in St. Louis, St Louis, Missouri; and the George Washington University Biostatistics Center, Washington, DC; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland., Saade GR, Clifton RG, Sandoval GJ, Hughes BL, Reddy UM, Bartholomew A, Salazar A, Chien EK, Tita ATN, Thorp JM Jr, Metz TD, Wapner RJ, Sabharwal V, Simhan HN, Swamy GK, Heyborne KD, Sibai BM, Grobman WA, El-Sayed YY, Casey BM, Parry S, Rathore M, Diaz-Velasco R, Puga AM, Wiznia A, Kovacs A, Garry DJ, Macones GA |
| مؤلفون مشاركون: | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network* |
| المصدر: | Obstetrics and gynecology [Obstet Gynecol] 2023 Sep 01; Vol. 142 (3), pp. 449-456. |
| نوع المنشور: | Observational Study; Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401101 Publication Model: Print Cited Medium: Internet ISSN: 1873-233X (Electronic) Linking ISSN: 00297844 NLM ISO Abbreviation: Obstet Gynecol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2004- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York. |
| مواضيع طبية MeSH: | Hepacivirus*/genetics , Hepatitis C*/epidemiology, Child ; Female ; Pregnancy ; Humans ; Prospective Studies ; Risk Factors ; RNA ; Uterine Hemorrhage |
| مستخلص: | Objective: To estimate the rate of perinatal transmission of hepatitis C virus (HCV) infection, to identify risk factors for perinatal transmission of HCV infection, and to determine the viremic threshold for perinatal transmission. Methods: This was a prospective, multicenter, observational study of pregnant individuals at less than 24 weeks of gestation screened for HCV infection from 2012 to 2018 in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Individuals found to be HCV antibody-positive were followed throughout pregnancy. Children were followed for evidence of perinatal transmission at 2-6 months (HCV RNA testing) and at 18-24 months (HCV RNA and antibody testing) of life. The primary outcome was perinatal transmission, defined as positive test results at either follow-up time point. Results: A total of 109,379 individuals were screened for HCV infection. Of the 1,224 participants who screened positive, 772 (63.1%) enrolled and 432 of those 772 (56.0%) had data available to assess primary outcome. The overall rate of perinatal transmission was 6.0% (26/432, 95% CI 4.0-8.7%). All children with HCV infection were born to individuals with demonstrable viremia. In viremic participants (n=314), the perinatal transmission rate was 8.0% (95% CI 5.2-11.5%). Risk factors for perinatal transmission included HCV RNA greater than 106 international units/mL (adjusted odds ratio [aOR] 8.22, 95% CI 3.16-21.4) and vaginal bleeding reported at any time before delivery (aOR 3.26, 95% CI 1.32-8.03). A viremic threshold for perinatal transmission could not be established. Conclusion: Perinatal transmission of HCV infection was limited to viremic individuals. High viral loads and antepartum bleeding were associated with perinatal transmission. Competing Interests: Financial Disclosure Mona Prasad served on the medical advisory board for Gilead. Brenna Hughes disclosed receiving payment from UpToDate and the Johns Hopkins DSMB. Ana Puga disclosed that she is cochair of the Broward County Perinatal HIV Network (no compensation) and a full-time employee of ViiV Healthcare since 2018. Torri D. Metz disclosed receiving UpToDate royalties for two topics on trial of labor after cesarean. Her institution received payment from Gestvision for her being a site PI for a preeclampsia point-of-care test (institution received money to conduct study [ended August 2020]) and from Pfizer for being a site PI for a Phase III respiratory syncytial virus (RSV) vaccine trial (institution received money to conduct the study). She has been a member of the medical advisory board for Pfizer, a site PI for a COVID-19 vaccination trial, and has served on the Board of Directors for the Society for Maternal-Fetal Medicine. Geeta Swamy reports money was paid to her from GlaxoSmithKline, Pfizer, and WebMD/Medscape. Andrew Wiznia received payment for a consultancy with Janssen Pharmaceuticals, where he has been a chairperson of the Independent Data Safety Monitoring Board. He has also received payment from Merck for a consultancy and protocol development. The other authors did not report any potential conflicts of interest. (Copyright © 2023 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.) |
| التعليقات: | Comment in: Obstet Gynecol. 2023 Sep 1;142(3):447-448. doi: 10.1097/AOG.0000000000005308. (PMID: 37535958) |
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| معلومات مُعتمدة: | U10 HD040500 United States HD NICHD NIH HHS; U10 HD040544 United States HD NICHD NIH HHS; UG1 HD034116 United States HD NICHD NIH HHS; UG1 HD040560 United States HD NICHD NIH HHS; UG1 HD087230 United States HD NICHD NIH HHS; U10 HD040485 United States HD NICHD NIH HHS; U10 HD034116 United States HD NICHD NIH HHS; UG1 HD068258 United States HD NICHD NIH HHS; U10 HD027869 United States HD NICHD NIH HHS; UM1AI-106716-15 United States NH NIH HHS; U10 HD040512 United States HD NICHD NIH HHS; UG1 HD027869 United States HD NICHD NIH HHS; U10 HD068268 United States HD NICHD NIH HHS; UG1 HD053097 United States HD NICHD NIH HHS; HHSN275201800001C United States HD NICHD NIH HHS; UG1 HD027915 United States HD NICHD NIH HHS; UG1 HD087192 United States HD NICHD NIH HHS; UM1 AI068632 United States AI NIAID NIH HHS; UG1 HD040544 United States HD NICHD NIH HHS; UG1 HD034208 United States HD NICHD NIH HHS; UG1 HD040512 United States HD NICHD NIH HHS; U10 HD027915 United States HD NICHD NIH HHS; U10 HD068282 United States HD NICHD NIH HHS; UG1 HD040545 United States HD NICHD NIH HHS; UG1 HD040485 United States HD NICHD NIH HHS; UG1 HD068268 United States HD NICHD NIH HHS; UM1 AI068616 United States AI NIAID NIH HHS; U10 HD040560 United States HD NICHD NIH HHS; U10 HD034208 United States HD NICHD NIH HHS; U10 HD053097 United States HD NICHD NIH HHS; U10 HD068258 United States HD NICHD NIH HHS; UG1 HD040500 United States HD NICHD NIH HHS; UG1 HD068282 United States HD NICHD NIH HHS; U10 HD036801 United States HD NICHD NIH HHS; U24 HD036801 United States HD NICHD NIH HHS; U10 HD040545 United States HD NICHD NIH HHS; UM1 AI106716 United States AI NIAID NIH HHS; U01 HD036801 United States HD NICHD NIH HHS; HHSN275201800001I United States HD NICHD NIH HHS |
| المشرفين على المادة: | 63231-63-0 (RNA) |
| تواريخ الأحداث: | Date Created: 20230817 Date Completed: 20230821 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC10437102 |
| DOI: | 10.1097/AOG.0000000000005306 |
| PMID: | 37590978 |
| قاعدة البيانات: | MEDLINE |
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