دورية أكاديمية
أعرض في EDS

Pregnancy Rates in Women With Polycystic Ovary Syndrome (PCOS) Using Letrozole Versus Clomiphene Citrate: A Retrospective Record Review.

التفاصيل البيبلوغرافية
العنوان: Pregnancy Rates in Women With Polycystic Ovary Syndrome (PCOS) Using Letrozole Versus Clomiphene Citrate: A Retrospective Record Review.
المؤلفون: Bahawi YO; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Radwan EM; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Khouj MA; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Alotaibi RK; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Bajuwaiber NA; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Baghlaf LF; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., AlFaraj WF; Department of Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU., Oraif AM; Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, SAU.
المصدر: Cureus [Cureus] 2023 Jul 21; Vol. 15 (7), pp. e42257. Date of Electronic Publication: 2023 Jul 21 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Background and objectives Polycystic ovary syndrome (PCOS) is a prominent cause of anovulation. Thus, this study aimed to compare the pregnancy rates of women with PCOS treated with letrozole (LE) or clomiphene citrate (CC) at King Abdulaziz University Hospital. Patients and methods A retrospective record review was conducted from April 2021 to August 2022 to review 1370 records of women with PCOS from January 2015 to December 2021. Sixty-one patients were included in this analysis. Chi-square tests and independent sample t-tests were used to analyze various associations. Statistical significance was set at P < 0.05. Results Letrozole was associated with a higher pregnancy rate (41.7%) than CC (32.0%). However, this relationship was not statistically significant ( P = .619). Furthermore, patients treated with letrozole required fewer cycles to achieve pregnancy (two cycles compared to three cycles). The different age groups and body mass indexes did not affect the pregnancy rate in either group. Conclusion No significant difference was found between CC and LE in ovulation induction and outcome among PCOS patients. Studies with larger sample sizes and multiple centers should be conducted in Saudi Arabia to obtain more conclusive results, which will eventually lead to changes in guidelines for anovulation treatment in women with PCOS.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2023, Bahawi et al.)
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فهرسة مساهمة: Keywords: clomiphene citrate; infertility drugs; letrozole; polycystic ovary syndrome (pcos); pregnancy rates
تواريخ الأحداث: Date Created: 20230822 Latest Revision: 20230823
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10440068
DOI: 10.7759/cureus.42257
PMID: 37605693
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.42257