دورية أكاديمية
أعرض في EDS

Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection.

التفاصيل البيبلوغرافية
العنوان: Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection.
المؤلفون: Ewald JT; Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA., Steinbrekera B; Department of Pediatrics, University of South Dakota, Sioux Falls, SD 57069, USA., Bermick JR; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Santillan DA; Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Colaizy TT; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Santillan MK; Department of Obstetrics and Gynecology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Roghair RD; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
المصدر: Pediatric reports [Pediatr Rep] 2023 Aug 10; Vol. 15 (3), pp. 483-493. Date of Electronic Publication: 2023 Aug 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551542 Publication Model: Electronic Cited Medium: Print ISSN: 2036-749X (Print) Linking ISSN: 2036749X NLM ISO Abbreviation: Pediatr Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2020- : Basel, Switzerland : MDPI
Original Publication: Pavia, Italy : PAGEPress
مستخلص: Preterm delivery can be precipitated by preeclampsia or infection, and preterm infants are at heightened risk of postnatal infection. Little is known about the ontogeny of inflammatory biomarkers in extremely preterm infants. We hypothesized that suspected prenatal infection (clinical chorioamnionitis or spontaneous preterm labor) and clinically diagnosed postnatal infection would be associated with unique biomarker signatures, and those patterns would be influenced by the degree of prematurity. Venous blood was collected daily for the first week and weekly for up to 14 additional weeks from 142 neonates born at 22-32 weeks gestation. A custom array was utilized to measure monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6). C-reactive protein (CRP) levels were obtained from the electronic medical record. Independent of gestational age, MCP-1 was significantly increased ( p < 0.001) in association with maternal preeclampsia, but MCP-1 was decreased ( p < 0.01), and CRP was increased ( p < 0.01) in the presence of chorioamnionitis with funisitis. IL-6 and CRP were both increased in infants diagnosed with postnatal infection, with peak levels observed on days 2 and 3, respectively. In conclusion, suspected prenatal and postnatal infections and non-infectious complications of pregnancy are associated with unique biomarker profiles, independent of gestational age, including over a 2-fold increase in MCP-1 among newborns of mothers with preeclampsia. Further, in those clinically diagnosed with a postnatal infection in the absence of antenatal infection concerns, IL-6 increases before CRP, emphasizing a potential role for expanded biomarker screening if antibiotics are initially avoided in infants delivered for maternal indications.
References: Diagnostics (Basel). 2023 Feb 20;13(4):. (PMID: 36832300)
Front Pediatr. 2022 Mar 23;10:840778. (PMID: 35402358)
Mediators Inflamm. 2013;2013:753752. (PMID: 23690669)
Pediatr Res. 2019 Jun;85(7):1016-1023. (PMID: 30845123)
J Clin Lab Anal. 2010;24(6):407-12. (PMID: 21089127)
Cold Spring Harb Perspect Biol. 2014 Sep 04;6(10):a016295. (PMID: 25190079)
Innate Immun. 2009 Apr;15(2):101-7. (PMID: 19318420)
BMC Immunol. 2010 Dec 02;11:59. (PMID: 21126355)
Diagnostics (Basel). 2020 Nov 20;10(11):. (PMID: 33233806)
Front Immunol. 2018 Apr 13;9:754. (PMID: 29706967)
Medicine (Baltimore). 2018 Nov;97(47):e13146. (PMID: 30461611)
Front Physiol. 2014 Oct 10;5:372. (PMID: 25346691)
J Interferon Cytokine Res. 2009 Jun;29(6):313-26. (PMID: 19441883)
Acta Paediatr. 2020 Apr;109(4):720-727. (PMID: 31562835)
J Matern Fetal Neonatal Med. 2021 Jan;34(2):253-258. (PMID: 30966828)
FEBS J. 2019 Jan;286(1):82-109. (PMID: 30565411)
BMJ. 2011 Apr 07;342:d1875. (PMID: 21474517)
Pediatr Res. 2017 Oct;82(4):574-583. (PMID: 28574980)
Eur J Obstet Gynecol Reprod Biol. 2006 Sep-Oct;128(1-2):34-9. (PMID: 16459014)
Biochem J. 1990 Feb 1;265(3):621-36. (PMID: 1689567)
J Matern Fetal Neonatal Med. 2019 Sep;32(17):2830-2836. (PMID: 29562764)
J Pediatr. 2020 Feb;217:59-65.e1. (PMID: 31604632)
J Interferon Cytokine Res. 2010 Sep;30(9):673-6. (PMID: 20726788)
Clin Chem. 2004 Feb;50(2):279-87. (PMID: 14752012)
Arch Dis Child Fetal Neonatal Ed. 2018 Jul;103(4):F391-F394. (PMID: 29382648)
BMC Res Notes. 2013 Dec 20;6:547. (PMID: 24359685)
Front Pediatr. 2022 Mar 08;10:840288. (PMID: 35345614)
Dev Psychobiol. 2019 Jul;61(5):739-751. (PMID: 30460694)
Am J Physiol Renal Physiol. 2022 Aug 1;323(2):F107-F119. (PMID: 35658715)
Early Hum Dev. 2016 Jul;98:1-6. (PMID: 27318328)
Immunol Cell Biol. 2018 Sep;96(8):792-804. (PMID: 29533486)
Lancet. 1998 Oct 17;352(9136):1271-7. (PMID: 9788457)
BMC Pediatr. 2021 Oct 19;21(1):458. (PMID: 34666725)
Front Immunol. 2023 Jan 06;13:1053457. (PMID: 36685497)
Circulation. 2005 Aug 23;112(8):1113-20. (PMID: 16116069)
JAMA. 2015 Sep 8;314(10):1039-51. (PMID: 26348753)
Clin Chim Acta. 2017 Oct;473:228-236. (PMID: 28038968)
BJOG. 2003 Apr;110 Suppl 20:8-16. (PMID: 12763105)
Swiss Med Wkly. 2014 Jun 25;144:w13981. (PMID: 24964177)
N Engl J Med. 2008 Jul 17;359(3):262-73. (PMID: 18635431)
J Clin Diagn Res. 2016 May;10(5):DC13-7. (PMID: 27437213)
معلومات مُعتمدة: R01 HD089940 United States HD NICHD NIH HHS; UL1TR002537 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: adipokine; chemokine (C-C motif) ligand 2; interleukin-6; leptin; neonatal; preeclampsia
تواريخ الأحداث: Date Created: 20230822 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10443264
DOI: 10.3390/pediatric15030044
PMID: 37606448
قاعدة البيانات: MEDLINE
الوصف
تدمد:2036-749X
DOI:10.3390/pediatric15030044