دورية أكاديمية
أعرض في EDS

Effect of Test and Treat on clinical outcomes in Nigeria: A national retrospective study.

التفاصيل البيبلوغرافية
العنوان: Effect of Test and Treat on clinical outcomes in Nigeria: A national retrospective study.
المؤلفون: Lavoie MC; Division of Global Health Sciences, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Center for International Health Education and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Ehoche A; Center for International Health Education and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Blanco N; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Center for International Health Education and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Ahmed El-Imam I; Center for International Health Education and Biosecurity, MGIC-an Affiliate of the University of Maryland Baltimore, Abuja, Nigeria., Oladipo A; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Dalhatu I; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Odafe S; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Adebajo S; Center for International Health Education and Biosecurity, MGIC-an Affiliate of the University of Maryland Baltimore, Abuja, Nigeria., Ng AH; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Rapoport L; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Center for International Health Education and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Lawton JG; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Center for International Health Education and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States of America., Obanubi C; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Onotu D; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Patel S; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Ikpeazu A; National AIDS and STI Control Programme-Federal Ministry of Health, Abuja, Federal Capital Territory, Nigeria., Ashefor G; National Agency for the Control of AIDS, Abuja, Nigeria., Adebobola B; National AIDS and STI Control Programme-Federal Ministry of Health, Abuja, Federal Capital Territory, Nigeria., Adetinuke Boyd M; Centers for Disease Control and Prevention, CGH/DGHT, Abuja, Nigeria., Aliyu G; National Agency for the Control of AIDS, Abuja, Nigeria., Stafford KA; Division of Global Health Sciences, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Center for International Health Education and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
المصدر: PloS one [PLoS One] 2023 Aug 22; Vol. 18 (8), pp. e0284847. Date of Electronic Publication: 2023 Aug 22 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Cognition* , Frailty*, Humans ; Nigeria/epidemiology ; Retrospective Studies ; Early Intervention, Educational
مستخلص: Background: In Nigeria, results from the pilot of the Test and Treat strategy showed higher loss to follow up (LTFU) among people living with HIV compared to before its implementation. The aim of this evaluation was to assess the effects of antiretroviral therapy (ART) initiation within 14 days on LTFU at 12 months and viral suppression.
Methods: We conducted a retrospective cohort study using routinely collected de-identified patient-level data hosted on the Nigeria National Data Repository from 1,007 facilities. The study population included people living with HIV age ≥15. We used multivariable Cox proportional frailty hazard models to assess time to LTFU comparing ART initiation strategy and multivariable log-binomial regression for viral suppression.
Results: Overall, 26,937 (38.13%) were LTFU at 12 months. Among individuals initiated within 14 days, 38.4% were LTFU by 12 months compared to 35.4% for individuals initiated >14 days (p<0.001). In the adjusted analysis, individuals who were initiated ≤14 days after HIV diagnosis had a higher hazard of being LTFU (aHR 1.15, 95% CI 1.10-1.20) than individuals initiated after 14 days of HIV diagnosis. Among individuals with viral load results, 86.2% were virally suppressed. The adjusted risk ratio for viral suppression among individuals who were initiated ≤14 days compared to >14 days was not statistically significant.
Conclusion: LTFU was higher among individuals who were initiated within 14 days compared to greater than 14 days after HIV diagnosis. There was no difference for viral suppression. The provision of early tailored interventions to support newly diagnosed people living may contribute to reducing LTFU.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.)
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تواريخ الأحداث: Date Created: 20230822 Date Completed: 20230824 Latest Revision: 20230828
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10443836
DOI: 10.1371/journal.pone.0284847
PMID: 37607206
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0284847