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Sophora genomes provide insight into the evolution of alkaloid metabolites along with small-scale gene duplication.

التفاصيل البيبلوغرافية
العنوان: Sophora genomes provide insight into the evolution of alkaloid metabolites along with small-scale gene duplication.
المؤلفون: Kang YJ; Division of Bio & Medical Bigdata Department (BK4 Program), Gyeongsang National University, Jinju, 52828, Republic of Korea.; Division of Life Science Department, Gyeongsang National University, Jinju, Republic of Korea., Park H; Division of Bio & Medical Bigdata Department (BK4 Program), Gyeongsang National University, Jinju, 52828, Republic of Korea., Lee Y; Division of Bio & Medical Bigdata Department (BK4 Program), Gyeongsang National University, Jinju, 52828, Republic of Korea., Yoon S; Division of Bio & Medical Bigdata Department (BK4 Program), Gyeongsang National University, Jinju, 52828, Republic of Korea., Kwak M; National Institute of Biological Resources, Incheon, 22689, Republic of Korea. mhkwak@korea.kr.
المصدر: BMC genomics [BMC Genomics] 2023 Aug 22; Vol. 24 (1), pp. 475. Date of Electronic Publication: 2023 Aug 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Sophora*/genetics , Alkaloids* , Antineoplastic Agents*, Gene Duplication ; Genomics ; Sophora flavescens
مستخلص: The genus Sophora (Fabaceae) includes medicinal plants that have been used in East Asian countries since antiquity. Sophora flavescens is a perennial herb indigenous to China, India, Japan, Korea, and Russia. Its dried roots have antioxidant, anti-inflammatory, antibacterial, apoptosis-modulating, and antitumor efficacy. The congeneric S. koreensis is endemic to Korea and its genome is less than half the size of that of S. flavescens. Nevertheless, this discrepancy can be used to assemble and validate the S. flavescens genome. A comparative genomic study of the two genomes can disclose the recent evolutionary divergence of the polymorphic phenotypic profiles of these species. Here, we used the PacBio sequencing platform to sequence and assemble the S. koreensis and S. flavescens genomes. We inferred that it was mainly small-scale duplication that occurred in S. flavescens. A KEGG analysis revealed pathways that might regulate the pharmacologically important secondary metabolites in S. flavescens and S. koreensis. The genome assemblies of Sophora spp. could be used in comparative genomics and data mining for various plant natural products.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
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معلومات مُعتمدة: NIBR201905102 The genetic evaluation of indigenous vascular plants IV-2
فهرسة مساهمة: Keywords: Congeneric; Divergence; Evolution; Functional annotation; Genome; Phylogeny; Secondary metabolite; Small-scale duplication; Sophora
المشرفين على المادة: 0 (Alkaloids)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20230823 Date Completed: 20230824 Latest Revision: 20231118
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10464357
DOI: 10.1186/s12864-023-09516-w
PMID: 37608245
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2164
DOI:10.1186/s12864-023-09516-w