دورية أكاديمية
Brazil Nut-Enriched Diet Modulates Enteric Glial Cells and Gut Microbiota in an Experimental Model of Chronic Kidney Disease.
| العنوان: | Brazil Nut-Enriched Diet Modulates Enteric Glial Cells and Gut Microbiota in an Experimental Model of Chronic Kidney Disease. |
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| المؤلفون: | Almeida PP; Cardiovascular Sciences Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Da Cruz BO; Cardiovascular Sciences Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Thomasi B; Department of Physiology, Neuroscience Program, Michigan State University (MSU), East Lansing, Michigan, USA., Menezes ÁC; Cardiovascular Sciences Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Brito ML; Pathology Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Costa NDS; Cardiovascular Sciences Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Ito RVA; Medicine Graduation, Serra dos Órgãos University Center, Teresópolis, Rio de Janeiro, Brazil., Degani VAN; Clinic and Animal Reproduction Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Daleprane JB; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil., Magliano DC; Pathology Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Tavares-Gomes AL; Neurosciences Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil., Stockler-Pinto MB; Cardiovascular Sciences Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.; Pathology Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil.; Nutrition Sciences Post Graduate Program, Fluminense Federal University (UFF), Niterói, Rio de Janeiro, Brazil. |
| المصدر: | Journal of the American Nutrition Association [J Am Nutr Assoc] 2024 Feb; Vol. 43 (2), pp. 201-212. Date of Electronic Publication: 2023 Aug 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 9918300687506676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2769-707X (Electronic) Linking ISSN: 27697061 NLM ISO Abbreviation: J Am Nutr Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Philadelphia, Pennsylvania?] : Taylor & Francis Group, [2022]- |
| مواضيع طبية MeSH: | Bertholletia* , Gastrointestinal Microbiome* , Renal Insufficiency, Chronic*/metabolism, Rats ; Animals ; Diet ; Neuroglia/metabolism |
| مستخلص: | Introduction: Chronic kidney disease (CKD) promotes gut dysbiosis, and enteric glial reactivity, a feature of intestinal inflammation. Brazil nut modulated enteric glial profile in healthy animals and could modulate these cells in 5/6 nephrectomized rats. Methods: A 5/6 nephrectomy-induced CKD and Sham-operated rats were divided as follows: CKD and Sham received a standard diet and CKD-BN and Sham-BN received a 5% Brazil nut enriched-diet. The protein content of glial fibrillary acid protein (GFAP), enteric glial marker, and GPx protein content and activity were assessed in the colon. The major phyla of gut microbiota were assessed. Results: CKD-BN group presented a decrease in GFAP content ( p = 0.0001). The CKD-BN group modulated the abundance of Firmicutes , increasing its proportion compared to the CKD group. The CKD-BN group showed increased GPx activity in the colon ( p = 0.0192), despite no significant difference in protein content. Conclusion: Brazil nut-enriched diet consumption decreased enteric glial reactivity and modulated gut microbiota in the CKD experimental model. |
| فهرسة مساهمة: | Keywords: Brazil nut; chronic kidney disease; enteric glia; gut microbiota |
| تواريخ الأحداث: | Date Created: 20230823 Date Completed: 20240129 Latest Revision: 20240129 |
| رمز التحديث: | 20240129 |
| DOI: | 10.1080/27697061.2023.2247057 |
| PMID: | 37611162 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 2769-707X |
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| DOI: | 10.1080/27697061.2023.2247057 |