دورية أكاديمية
أعرض في EDS

Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice.

التفاصيل البيبلوغرافية
العنوان: Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice.
المؤلفون: Beetler DJ; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, 55902, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA., Bruno KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.; Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, 32608, USA., Watkins MM; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, 55902, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA., Xu V; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Chekuri I; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Giresi P; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Di Florio DN; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, 55902, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA., Whelan ER; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, 55902, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA., Edenfield BH; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, 32224, USA., Walker SA; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 55902, USA.; Department of Biochemistry and Molecular Biology, Rochester, MN, 55902, USA., Morales-Lara AC; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Hill AR; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Jain A; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, 55902, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Auda ME; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Macomb LP; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Shapiro KA; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Keegan KC; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Wolfram J; School of Chemical Engineering, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia., Behfar A; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.; Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, 55905, USA., Stalboerger PG; Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, 55905, USA., Terzic A; Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic Center for Regenerative Medicine, Rochester, MN, 55905, USA.; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, 55905, USA., Farres H; Department of Vascular Surgery, Mayo Clinic, Jacksonville, FL, 32224, USA., Cooper LT; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA., Fairweather D; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, 55902, USA.; Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.; Department of Immunology, Mayo Clinic, Jacksonville, FL, 32224, USA.
المصدر: Small (Weinheim an der Bergstrasse, Germany) [Small] 2023 Dec; Vol. 19 (49), pp. e2303317. Date of Electronic Publication: 2023 Aug 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2005-
مواضيع طبية MeSH: Myocarditis* , Cardiomyopathy, Dilated*/metabolism, Humans ; Mice ; Male ; Female ; Animals ; Myocardium/metabolism ; Immunity, Innate ; Macrophages/metabolism
مستخلص: Patients with viral myocarditis are at risk of sudden death and may progress to dilated cardiomyopathy (DCM). Currently, no disease-specific therapies exist to treat viral myocarditis. Here it is examined whether reconstituted, lyophilized extracellular vesicles (EVs) from platelets from healthy men and women reduce acute or chronic myocarditis in male mice. Human-platelet-derived EVs (PEV) do not cause toxicity, damage, or inflammation in naïve mice. PEV administered during the innate immune response significantly reduces myocarditis with fewer epidermal growth factor (EGF)-like module-containing mucin-like hormone receptor-like 1 (F4/80) macrophages, T cells (cluster of differentiation molecules 4 and 8, CD4 and CD8), and mast cells, and improved cardiac function. Innate immune mediators known to increase myocarditis are decreased by innate PEV treatment including Toll-like receptor (TLR)4 and complement. PEV also significantly reduces perivascular fibrosis and remodeling including interleukin 1 beta (IL-1β), transforming growth factor-beta 1, matrix metalloproteinase, collagen genes, and mast cell degranulation. PEV given at days 7-9 after infection reduces myocarditis and improves cardiac function. MicroRNA (miR) sequencing reveals that PEV contains miRs that decrease viral replication, TLR4 signaling, and T-cell activation. These data show that EVs from the platelets of healthy individuals can significantly reduce myocarditis and improve cardiac function.
(© 2023 The Authors. Small published by Wiley-VCH GmbH.)
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معلومات مُعتمدة: R21 AI163302 United States AI NIAID NIH HHS; TL1 TR002380 United States NH NIH HHS; R21 AI154927 United States AI NIAID NIH HHS; R21 AI152318 United States AI NIAID NIH HHS; R21 AI145356 United States AI NIAID NIH HHS; R01 HL164520 United States HL NHLBI NIH HHS; TL1 TR002380 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: TLR4; cardiomyopathy; complement; microRNA; regenerative medicine
تواريخ الأحداث: Date Created: 20230824 Date Completed: 20231216 Latest Revision: 20240207
رمز التحديث: 20240207
مُعرف محوري في PubMed: PMC10840864
DOI: 10.1002/smll.202303317
PMID: 37612820
قاعدة البيانات: MEDLINE
الوصف
تدمد:1613-6829
DOI:10.1002/smll.202303317