دورية أكاديمية
أعرض في EDS

miR-499a rs3746444 A>G Polymorphism Is Correlated with Type 2 Diabetes Mellitus and Diabetic Polyneuropathy in a Romanian Cohort: A Preliminary Study.

التفاصيل البيبلوغرافية
العنوان: miR-499a rs3746444 A>G Polymorphism Is Correlated with Type 2 Diabetes Mellitus and Diabetic Polyneuropathy in a Romanian Cohort: A Preliminary Study.
المؤلفون: Burada E; Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Department of Neurology, Clinical Hospital of Neuropsychiatry Craiova, 200473 Craiova, Romania., Roșu MM; Department of Diabetes, Nutrition and Metabolic Diseases, Emergency Clinical County Hospital Craiova, 200642 Craiova, Romania., Sandu RE; Department of Neurology, Clinical Hospital of Neuropsychiatry Craiova, 200473 Craiova, Romania.; Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Burada F; Laboratory of Human Genomics, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.; Regional Centre of Medical Genetics Dolj, Emergency Clinical County Hospital Craiova, 200642 Craiova, Romania., Cucu MG; Laboratory of Human Genomics, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.; Regional Centre of Medical Genetics Dolj, Emergency Clinical County Hospital Craiova, 200642 Craiova, Romania., Streață I; Laboratory of Human Genomics, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.; Regional Centre of Medical Genetics Dolj, Emergency Clinical County Hospital Craiova, 200642 Craiova, Romania., Petre-Mandache B; Laboratory of Human Genomics, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Popescu-Hobeanu G; Laboratory of Human Genomics, University of Medicine and Pharmacy of Craiova, 200638 Craiova, Romania.; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Cara ML; Department of Public Health, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Țucă AM; Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Pinoșanu E; Department of Neurology, Clinical Hospital of Neuropsychiatry Craiova, 200473 Craiova, Romania.; Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Albu CV; Department of Neurology, Clinical Hospital of Neuropsychiatry Craiova, 200473 Craiova, Romania.; Department of Neurology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
المصدر: Genes [Genes (Basel)] 2023 Jul 27; Vol. 14 (8). Date of Electronic Publication: 2023 Jul 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/genetics , Diabetic Neuropathies*/genetics , MicroRNAs*/genetics, Adult ; Humans ; Romania ; Polymorphism, Single Nucleotide
مستخلص: Type 2 diabetes mellitus (T2DM) is a common metabolic disorder that results from complex interactions of both environmental and genetic factors. Many single nucleotide polymorphisms (SNPs), including noncoding RNA genes, have been investigated for their association with susceptibility to T2DM and its complications, with little evidence available regarding Caucasians. The aim of the present study was to establish whether four miRNA SNPs (miR-27a rs895819 T>C, miR-146a rs2910164 G>C, miR-196a2 rs11614913 C>T, and miR-499a rs3746444 A>G) are correlated with susceptibility to T2DM and/or diabetic polyneuropathy (DPN) in a Romanian population. A total of 167 adult T2DM patients and 324 age- and sex-matched healthy controls were included in our study. miRNA SNPs were detected by real-time PCR using a TaqMan genotyping assay. A significant association with T2DM was observed only for the miR-499a rs3746444 A>G SNP in all the tested models, and the frequencies of both the miR-499a rs3746444 AG and the GG genotypes were higher in the T2DM patients compared to the controls. No correlation was observed for the miR-27a rs895819 T>C, miR-146a rs2910164 G>C, or miR-196a2 rs11614913 C>T SNPs in any genetic model. When we assessed the association of these SNPs with DPN separately, we found a positive association for the miR-499a rs3746444 SNP in both codominant and dominant models (OR 6.47, 95% CI: 1.71-24.47; OR 2.30, 95% CI: 1.23-4.29, respectively). In conclusion, this study shows that miR-499a rs3746444 A>G may influence both T2DM and DPN susceptibility, with carriers of the GG genotype and the G allele being at an increased risk in the Romanian population.
References: Diabetologia. 2010 Jun;53(6):1099-109. (PMID: 20198361)
Clin Lab. 2016 Aug 1;62(8):1553-1561. (PMID: 28164605)
Hum Mutat. 2009 Jan;30(1):79-84. (PMID: 18634034)
Int J Biol Sci. 2018 Aug 6;14(11):1483-1496. (PMID: 30263000)
Diabetes Metab Syndr Obes. 2019 Dec 18;12:2689-2706. (PMID: 31908510)
Int J Med Sci. 2015 Oct 20;12(11):875-80. (PMID: 26640407)
Cell. 2007 Jun 29;129(7):1401-14. (PMID: 17604727)
Diabetes Res Clin Pract. 2022 Jan;183:109119. (PMID: 34879977)
J Diabetes Complications. 2018 Jan;32(1):11-17. (PMID: 29108839)
J Pers Med. 2019 Nov 25;9(4):. (PMID: 31775219)
Mol Cell Biochem. 2011 May;351(1-2):197-205. (PMID: 21249428)
J Res Med Sci. 2020 Jun 30;25:56. (PMID: 33088293)
Cell. 2004 Jan 23;116(2):281-97. (PMID: 14744438)
Acta Diabetol. 2014 Aug;51(4):663-71. (PMID: 24682535)
Mol Cell. 2011 Sep 16;43(6):892-903. (PMID: 21925378)
Chin Med J (Engl). 2015 Feb 20;128(4):533-9. (PMID: 25673459)
Epigenomics. 2020 Apr;12(7):575-585. (PMID: 32400192)
Diabetes Care. 2020 Jan;43(Suppl 1):S14-S31. (PMID: 31862745)
Diabetes. 2017 Nov;66(11):2888-2902. (PMID: 28566273)
Nat Rev Endocrinol. 2018 Feb;14(2):88-98. (PMID: 29219149)
Biochem Biophys Res Commun. 2010 Feb 12;392(3):323-8. (PMID: 20060380)
PLoS One. 2016 Feb 09;11(2):e0148683. (PMID: 26859150)
Genome Res. 2009 Jan;19(1):92-105. (PMID: 18955434)
J Endocrinol Invest. 2016 Oct;39(10):1187-93. (PMID: 27300034)
Front Genet. 2021 Dec 01;12:793523. (PMID: 34925466)
J Epidemiol Glob Health. 2020 Mar;10(1):107-111. (PMID: 32175717)
Nature. 2010 Aug 12;466(7308):835-40. (PMID: 20703300)
Front Immunol. 2020 Jul 22;11:1582. (PMID: 32793223)
Proc Natl Acad Sci U S A. 2008 May 20;105(20):7269-74. (PMID: 18474871)
Acta Diabetol. 2013 Dec;50(6):867-72. (PMID: 23532299)
Cell Physiol Biochem. 2015;36(6):2357-65. (PMID: 26279439)
Pharmacol Rep. 2009 Jul-Aug;61(4):595-603. (PMID: 19815941)
Nat Rev Dis Primers. 2015 Jul 23;1:15019. (PMID: 27189025)
Medicine (Baltimore). 2019 Nov;98(44):e17519. (PMID: 31689753)
Front Endocrinol (Lausanne). 2022 Sep 27;13:961635. (PMID: 36237193)
PLoS One. 2014 Dec 12;9(12):e115209. (PMID: 25500583)
Biomed Rep. 2022 May;16(5):37. (PMID: 35386109)
Cancer Sci. 2010 Oct;101(10):2241-7. (PMID: 20666778)
J Diabetes Complications. 2014 Sep-Oct;28(5):617-20. (PMID: 24972764)
DNA Cell Biol. 2016 Feb;35(2):81-7. (PMID: 26710106)
Med Sci Monit. 2014 Nov 16;20:2318-26. (PMID: 25399405)
BMC Endocr Disord. 2020 Mar 12;20(Suppl 1):134. (PMID: 32164656)
Endocr Connect. 2021 Nov 03;10(11):1393-1402. (PMID: 34596578)
Physiol Rev. 2011 Jul;91(3):827-87. (PMID: 21742789)
J Int Med Res. 2020 Aug;48(8):300060520931313. (PMID: 32812451)
J Clin Endocrinol Metab. 2012 Dec;97(12):E2271-6. (PMID: 23032062)
Phys Ther. 2008 Nov;88(11):1322-35. (PMID: 18801863)
J Cell Mol Med. 2011 Jan;15(1):14-23. (PMID: 21091634)
Mol Biol Rep. 2012 Jun;39(6):7019-23. (PMID: 22311030)
DNA Cell Biol. 2020 Aug;39(8):1467-1472. (PMID: 32311290)
J Diabetes Res. 2021 Oct 6;2021:5593608. (PMID: 34660810)
Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1183-7. (PMID: 19293314)
J Endocrinol Invest. 2018 May;41(5):557-566. (PMID: 29058209)
فهرسة مساهمة: Keywords: diabetic polyneuropathy; genotype; microRNAs; single nucleotide polymorphism; type 2 diabetes mellitus
المشرفين على المادة: 0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20230826 Date Completed: 20230828 Latest Revision: 20230829
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10454730
DOI: 10.3390/genes14081543
PMID: 37628595
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes14081543