دورية أكاديمية
The Role of Inflammatory Phenotype in Patients With Exacerbation-prone Asthma and Ongoing Therapy.
| العنوان: | The Role of Inflammatory Phenotype in Patients With Exacerbation-prone Asthma and Ongoing Therapy. |
|---|---|
| المؤلفون: | Pilia MF; Servei de Pneumologia, Hospital Universitari Vall d́Hebron, Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain., Cruz MJ; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain., Ma D; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Romero-Mesones C; Servei de Pneumologia, Hospital Universitari Vall d́Hebron, Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain., Espejo D; Servei de Pneumologia, Hospital Universitari Vall d́Hebron, Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain., Ojanguren A; Servei de Cirugía Torácica, Hospital Universitari de Bellvitge, Barcelona, Spain., Ramon MA; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain., Muñoz X; Servei de Pneumologia, Hospital Universitari Vall d́Hebron, Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain., Ojanguren I; Servei de Pneumologia, Hospital Universitari Vall d́Hebron, Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Electronic address: inigo.ojanguren@vallhebron.cat. |
| المصدر: | Archivos de bronconeumologia [Arch Bronconeumol] 2023 Nov; Vol. 59 (11), pp. 736-742. Date of Electronic Publication: 2023 Aug 05. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English; Spanish; Castilian |
| بيانات الدورية: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 0354720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1579-2129 (Electronic) Linking ISSN: 03002896 NLM ISO Abbreviation: Arch Bronconeumol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Madrid: Elsevier España Original Publication: Madrid : Sociedad Española de Patología Respiratoria [1964]- |
| مواضيع طبية MeSH: | Asthma* , Eosinophilia*, Humans ; Phenotype ; Respiratory System ; Sputum ; Inflammation |
| مستخلص: | Introduction: The risk factors for having frequent exacerbations are not well documented in cohort studies of patients with asthma on existing therapy. The objective of the present study was to compare the clinical and inflammatory characteristics of patients with exacerbation-prone asthma (EPA) with a history of two or more exacerbations in the previous year with those who had presented just one or no exacerbation. Methods: An ambispective observational study was conducted in a tertiary hospital. Patients diagnosed with moderate or severe asthma and ongoing therapy, whose inflammatory profile was determined by means of allergy and atopy status, blood eosinophilia and induced sputum were included. Patients were classified according to the number of asthma exacerbations in EPA (≥2 exacerbations in the previous year) vs. non-exacerbators (≤1 exacerbation in the previous year). Clinical, lung function and inflammatory characteristics of the two groups were compared. Results: Three hundred ten patients were visited in the Asthma Unit in 2018 and the combination of atopy and allergy status, blood eosinophilia and induced sputum was obtained in 96 (31%) patients. Of this latter group, 46 patients (47%) presented EPA compared to 50 (53%) non-exacerbators. Airway and blood eosinophilic inflammation did not differ between EPA and non-exacerbators in patients with asthma and ongoing therapy, and it was not a risk factor for EPA in our cohort. Conclusion: Airway or blood type 2 inflammation status is not a valid tool for recognizing EPA or predicting asthma exacerbations in asthma patients following controller therapy. (Copyright © 2023 SEPAR. Published by Elsevier España, S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Asthma; Asthma exacerbation; Induced sputum; Inflammatory phenotype; Severe asthma; Type 2 inflammation |
| تواريخ الأحداث: | Date Created: 20230828 Date Completed: 20231106 Latest Revision: 20231106 |
| رمز التحديث: | 20231106 |
| DOI: | 10.1016/j.arbres.2023.07.026 |
| PMID: | 37640656 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1579-2129 |
|---|---|
| DOI: | 10.1016/j.arbres.2023.07.026 |