دورية أكاديمية
أعرض في EDS

Efficacy of tumor necrosis factor inhibitors in hand osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

التفاصيل البيبلوغرافية
العنوان: Efficacy of tumor necrosis factor inhibitors in hand osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.
المؤلفون: Estee MM; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia., Cicuttini FM; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia., Page MJ; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia., Wluka AE; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia., Wang Y; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria 3004, Australia.
المصدر: Osteoarthritis and cartilage open [Osteoarthr Cartil Open] 2023 Aug 12; Vol. 5 (4), pp. 100404. Date of Electronic Publication: 2023 Aug 12 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101767068 Publication Model: eCollection Cited Medium: Internet ISSN: 2665-9131 (Electronic) Linking ISSN: 26659131 NLM ISO Abbreviation: Osteoarthr Cartil Open Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Elsevier Ltd., [2019]-
مستخلص: Objectives: This study aimed at systematically review the evidence for the efficacy of Tumor Necrosis Factor (TNF) inhibitors on symptoms and structural outcomes in hand osteoarthritis.
Methods: Three databases were searched for randomized controlled trials examining the efficacy of TNF inhibitors in hand osteoarthritis. Two authors extracted data and assessed the risk of bias. The mean difference (MD) was calculated, and a random-effects meta-analysis was performed.
Results: Four studies were identified involving 276 participants. Meta-analysis showed that TNF inhibitors had no effect on pain at 4-6 weeks (MD -0.93, 95%CI -7.41 to 5.55; 2 studies) and 24-26 weeks (MD -3.82, 95%CI -11.46 to 3.83; 2 studies) and no effect on grip strength at 12 months (MD -0.35, 95%CI -1.08 to 0.37; 2 studies). There was limited evidence for the effect of TNF inhibitors on structural outcomes at 12 months. Subgroup analysis from 2 studies showed beneficial effect of TNF inhibitors on reducing the progression of structural outcomes in hand OA patients with signs of inflammation but not in those without inflammation. The certainty of the evidence was low for the effect of TNF inhibitor on pain and moderate for the effect on grip strength.
Conclusion: This study found no effect of TNF inhibitors on clinical outcomes in hand osteoarthritis over the short term (<6 weeks) and within one year, with some evidence for beneficial effect on structural outcomes.
Competing Interests: None.
(© 2023 The Author(s).)
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فهرسة مساهمة: Keywords: Hand osteoarthritis; Meta-analysis; Randomized controlled trials; Systematic review; Tumor necrosis factor inhibitors
تواريخ الأحداث: Date Created: 20230831 Latest Revision: 20230901
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10462838
DOI: 10.1016/j.ocarto.2023.100404
PMID: 37649531
قاعدة البيانات: MEDLINE
الوصف
تدمد:2665-9131
DOI:10.1016/j.ocarto.2023.100404