Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives.

التفاصيل البيبلوغرافية
العنوان:	Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives.
المؤلفون:	Zivković J; Institute for Medicinal Plants Research 'Dr. Josif Pančić', Tadeuša Košćuška 1, Belgrade, Serbia. jelenazivkovic1@yahoo.com., Kumar KA; Department of Obstetrics and Gynecology, Division of Basic Sciences and Translational Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA., Rushendran R; Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology (SRMIST), Kattankulatur, 603203, Tamil Nadu, India., Ilango K; School of Pharmacy, Hindustan Institute Technology and Science, Padur, Chennai, 603 103, India., Fahmy NM; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.; Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt., El-Nashar HAS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.; Center of Drug Discovery Research and Development, Ain Shams University, Cairo, Egypt., El-Shazly M; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo, Egypt.; Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Ezzat SM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.; Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt., Melgar-Lalanne G; Instituto de Ciencias Básicas, Universidad Veracruzana, Avda. Castelazo Ayala S/N, 91190, Xalapa, Veracruz, Mexico., Romero-Montero A; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico., Peña-Corona SI; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico., Leyva-Gomez G; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de México, Mexico., Sharifi-Rad J; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. javad.sharifirad@gmail.com., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. calinadaniela@gmail.com.
المصدر:	Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Feb; Vol. 397 (2), pp. 763-781. Date of Electronic Publication: 2023 Sep 01.
نوع المنشور:	Journal Article; Review
اللغة:	English
بيانات الدورية:	Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin, New York, Springer Verlag.
مواضيع طبية MeSH:	Mangifera* , Xanthones/pharmacology , Xanthones/therapeutic use, Animals ; Humans ; Biological Availability ; Plant Extracts/pharmacology ; Chronic Disease
مستخلص:	This review aims to provide an in-depth analysis of the pharmacological properties of mangiferin, focusing primarily on its bioavailability and mechanisms of action, and its potential therapeutic applications, especially in the context of chronic diseases. We conducted a comprehensive examination of in vitro and in vivo studies, as well as clinical trials involving mangiferin or plant extracts containing mangiferin. The primary source of mangiferin is Mangifera indica, but it's also found in other plant species from the families Anacardiaceae, Gentianaceae, and Iridaceae. Mangiferin has exhibited a myriad of therapeutic properties, presenting itself as a promising candidate for treating various chronic conditions including neurodegenerative disorders, cardiovascular diseases, renal and pulmonary diseases, diabetes, and obesity. Despite the promising results showcased in many in vitro studies and certain animal studies, the application of mangiferin has been limited due to its poor solubility, absorption, and overall bioavailability. Mangiferin offers significant therapeutic potential in treating a spectrum of chronic diseases, as evidenced by both in vitro and clinical trials. However, the challenges concerning its bioavailability necessitate further research, particularly in optimizing its delivery and absorption, to harness its full medicinal potential. This review serves as a comprehensive update on the health-promoting and therapeutic activities of mangiferin. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة:	Keywords: Chronic diseases; Clinical studies; Mangiferin; Mechanisms of action; Pharmacological properties
المشرفين على المادة:	1M84LD0UMD (mangiferin) 0 (Plant Extracts) 0 (Xanthones)
تواريخ الأحداث:	Date Created: 20230901 Date Completed: 20240117 Latest Revision: 20240122
رمز التحديث:	20240122
DOI:	10.1007/s00210-023-02682-4
PMID:	37658210
قاعدة البيانات:	MEDLINE

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تدمد:	1432-1912
DOI:	10.1007/s00210-023-02682-4