دورية أكاديمية
Association of first primary cancer with risk of subsequent primary cancer among survivors of adult-onset cancers in Kentucky and Appalachian Kentucky.
| العنوان: | Association of first primary cancer with risk of subsequent primary cancer among survivors of adult-onset cancers in Kentucky and Appalachian Kentucky. |
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| المؤلفون: | Chen Q; Markey Cancer Center, University of Kentucky, Lexington, KY, United States.; Division of Cancer Biostatistics, University of Kentucky, Lexington, KY, United States., Huang B; Markey Cancer Center, University of Kentucky, Lexington, KY, United States.; Division of Cancer Biostatistics, University of Kentucky, Lexington, KY, United States., Anderson AM; Markey Cancer Center, University of Kentucky, Lexington, KY, United States., Durbin EB; Markey Cancer Center, University of Kentucky, Lexington, KY, United States.; Department of Radiology, University of Kentucky, Lexington, KY, United States., Arnold SM; Markey Cancer Center, University of Kentucky, Lexington, KY, United States.; Department of Internal Medicine, University of Kentucky, Lexington, KY, United States., Kolesar JM; Markey Cancer Center, University of Kentucky, Lexington, KY, United States.; Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY, United States.; Department of Pharmacy Practice and Science, University of Kentucky, Lexington, KY, United States. |
| المصدر: | Frontiers in oncology [Front Oncol] 2023 Aug 17; Vol. 13, pp. 1193487. Date of Electronic Publication: 2023 Aug 17 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | Background: Appalachia is a region with significant cancer disparities in incidence and mortality compared to Kentucky and the United States. However, the contribution of these cancer health disparities to subsequent primary cancers (SPCs) among survivors of adult-onset cancers is limited. This study aimed to quantify the overall and cancer type-specific risks of SPCs among adult-onset cancer survivors by first primary cancer (FPC) types, residence and sex. Methods: This retrospective cohort study from the Kentucky Cancer Registry included 148,509 individuals aged 20-84 years diagnosed with FPCs from 2000-2014 (followed until December 31, 2019) and survived at least 5 years. Expected numbers of SPC were derived from incidence rates in the Kentucky population; standardized incidence ratio (SIR) compared with those expected in the general Kentucky population. Results: Among 148,509 survivors (50.2% women, 27.9% Appalachian), 17,970 SPC cases occurred during 829,530 person-years of follow-up (mean, 5.6 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 20 of the 30 FPC types, as compared with risks in the general population. Among women, the overall risk of developing any SPCs was statistically significantly higher for 20 of the 31 FPC types, as compared to the general population. The highest overall SIR were estimated among oral cancer survivors (SIR, 2.14 [95% CI, 1.97-2.33] among men, and among laryngeal cancer survivors (SIR, 3.62 [95% CI, 2.93-4.42], among women. Appalachian survivors had significantly increased risk of overall SPC and different site specific SPC when compared to non-Appalachian survivors. The highest overall SIR were estimated among laryngeal cancer survivors for both Appalachian and non-Appalachian residents (SIR, 2.50: 95%CI, 2.10-2.95; SIR, 2.02: 95% CI, 1.77-2.03, respectively). Conclusion: Among adult-onset cancer survivors in Kentucky, several FPC types were significantly associated with greater risk of developing an SPC, compared with the general population. Risk for Appalachian survivors was even higher when compared to non-Appalachian residents, but was not explained by higher risk of smoking related cancers. Cancers associated with smoking comprised substantial proportions of overall SPC incidence among all survivors and highlight the importance of ongoing surveillance and efforts to prevent new cancers among survivors. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Chen, Huang, Anderson, Durbin, Arnold and Kolesar.) |
| References: | BMC Cancer. 2014 Apr 18;14:272. (PMID: 24742063) CA Cancer J Clin. 2022 Jan;72(1):7-33. (PMID: 35020204) Lancet Oncol. 2009 Apr;10(4):321-2. (PMID: 19350698) JAMA Oncol. 2018 Jun 1;4(6):832-836. (PMID: 29167866) JAMA Netw Open. 2022 Sep 1;5(9):e2230925. (PMID: 36083583) JAMA. 2020 Dec 22;324(24):2521-2535. (PMID: 33351041) CA Cancer J Clin. 2022 Sep;72(5):409-436. (PMID: 35736631) Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1029-36. (PMID: 27371756) J Rural Health. 2017 Sep;33(4):375-381. (PMID: 27602545) N Engl J Med. 2016 Aug 25;375(8):794-8. (PMID: 27557308) Am J Clin Oncol. 2003 Feb;26(1):79-83. (PMID: 12576929) |
| معلومات مُعتمدة: | P30 CA177558 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Appalachian Kentucky; cancer associated risk factors; cancer disparities; cancer survivors; first primary cancer; subsequent primary cancer; surveillance |
| تواريخ الأحداث: | Date Created: 20230904 Latest Revision: 20230906 |
| رمز التحديث: | 20230906 |
| مُعرف محوري في PubMed: | PMC10470616 |
| DOI: | 10.3389/fonc.2023.1193487 |
| PMID: | 37664066 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2234-943X |
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| DOI: | 10.3389/fonc.2023.1193487 |