Alpha-ketoglutaric acid mitigates the detrimental effects of soy antigenic protein on the intestinal health and growth performance of Mirror carp Cyprinus carpio.

التفاصيل البيبلوغرافية
العنوان:	Alpha-ketoglutaric acid mitigates the detrimental effects of soy antigenic protein on the intestinal health and growth performance of Mirror carp Cyprinus carpio.
المؤلفون:	Zhou Z; College of Life Sciences, Huzhou University, Zhejiang Provincial Key Laboratory of Aquatic Bioresource Conservation and Development Technology, Huzhou, 313000, China.; Guangdong HAID Group Co., Ltd, Guangzhou, 511400, China., Zhao J; College of Life Sciences, Huzhou University, Zhejiang Provincial Key Laboratory of Aquatic Bioresource Conservation and Development Technology, Huzhou, 313000, China., de Cruz CR; Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia., Xu H; College of Life Sciences, Huzhou University, Zhejiang Provincial Key Laboratory of Aquatic Bioresource Conservation and Development Technology, Huzhou, 313000, China., Wang L; Animal Nutrition Laboratory, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin, 150070, China., Xu Q; College of Life Sciences, Huzhou University, Zhejiang Provincial Key Laboratory of Aquatic Bioresource Conservation and Development Technology, Huzhou, 313000, China. 02655@zjhu.edu.cn.
المصدر:	Fish physiology and biochemistry [Fish Physiol Biochem] 2023 Oct; Vol. 49 (5), pp. 951-965. Date of Electronic Publication: 2023 Sep 04.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 100955049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-5168 (Electronic) Linking ISSN: 09201742 NLM ISO Abbreviation: Fish Physiol Biochem Subsets: MEDLINE
أسماء مطبوعة:	Publication: Dordrecht ; Boston : Kluwer Academic Publishers Original Publication: Amsterdam ; Berkeley : Kugler, 1986-
مواضيع طبية MeSH:	Carps*/metabolism, Animals ; Ketoglutaric Acids ; Caspase 3/metabolism ; Caspase 9 ; Intestines ; Tumor Necrosis Factor-alpha/metabolism ; AMP-Activated Protein Kinases ; Diet/veterinary ; Transforming Growth Factor beta ; Animal Feed/analysis ; Dietary Supplements
مستخلص:	The study investigated the alleviated effects of Alpha-ketoglutaric acid (AKG) on the intestinal health of mirror carp (Cyprinus carpio Songpu) caused by soy antigenic protein. The diets were formulated from fishmeal (CON), 50% soybean meal (SBM), the mixture of glycinin and β-conglycinin (11 + 7S) and adding 1% AKG in the 11 + 7S (AKG). Carp (~ 4 g) in triplicate (30 fish per tank) was fed to apparent satiation thrice a day for six weeks. Compared with CON, SBM treatment resulted in significantly poor growth performance (P < 0.05), whereas 11 + 7S and AKG treatments were not significantly different from CON (P > 0.05). Gene expression of tumor necrosis factor (TNF-α) and interleukin-1 β (IL-1β) in proximal intestines (PI) and distal intestines (DI) were increased (P < 0.05), and transforming growth factor (TGF-β) in PI and middle intestines (MI) was decreased (P < 0.05) in both SBM and 11 + 7S. The caspase-3 in DI increased in SBM (P < 0.05) and the caspase-3 and caspase-9 in DI increased in 11 + 7S (P < 0.05); conversely, TGF-β in PI and MI was increased, TNF-α and IL-1β in the MI, caspase-3, and caspase-9 in DI was decreased in AKG (P < 0.05). The TOR (target of rapamycin) in PI and MI, ACC in PI, MI and DI was decreased in SBM (P < 0.05), the AMPK in the PI and DI, TOR in PI, MI and DI, ACC in PI and DI, 4E-BP in DI was reduced in 11 + 7S (P < 0.05). AMPK in the PI and DI, ACC in the PI and MI, TOR in PI, MI, and DI, 4E-BP in PI and DI was recovered by AKG supplementation (P < 0.05). Lipids and lipid-like metabolism, organic acids and derivatives metabolism increased in AKG dietary treatment. In conclusion, AKG reduces the expression of intestinal inflammation and apoptosis pathway and changes glycerophospholipid metabolism and sphingolipid metabolism in the intestine of fish. (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
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فهرسة مساهمة:	Keywords: AKG; Carp; Intestine; Metabolome; Soy antigen protein
المشرفين على المادة:	0 (Ketoglutaric Acids) EC 3.4.22.- (Caspase 3) EC 3.4.22.- (Caspase 9) 0 (Tumor Necrosis Factor-alpha) EC 2.7.11.31 (AMP-Activated Protein Kinases) 0 (Transforming Growth Factor beta)
تواريخ الأحداث:	Date Created: 20230904 Date Completed: 20231023 Latest Revision: 20231023
رمز التحديث:	20231023
DOI:	10.1007/s10695-023-01234-0
PMID:	37665506
قاعدة البيانات:	MEDLINE

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تدمد:	1573-5168
DOI:	10.1007/s10695-023-01234-0