دورية أكاديمية
Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancer.
| العنوان: | Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancer. |
|---|---|
| المؤلفون: | Lim YX; Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011N. University Ave, Ann Arbor, MI, USA., Mierzwa ML; Rogel Cancer Center, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI, USA.; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA., Sartor MA; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan Medical School, Ann Arbor, MI, USA., D'Silva NJ; Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011N. University Ave, Ann Arbor, MI, USA. njdsilva@umich.edu.; Rogel Cancer Center, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI, USA. njdsilva@umich.edu.; Pathology, University of Michigan Medical School, Ann Arbor, MI, USA. njdsilva@umich.edu. |
| المصدر: | Oncogene [Oncogene] 2023 Sep; Vol. 42 (40), pp. 2939-2955. Date of Electronic Publication: 2023 Sep 04. |
| نوع المنشور: | Journal Article; Review; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002->: Basingstoke : Nature Publishing Group Original Publication: Basingstoke, Hampshire, UK : Scientific & Medical Division, MacMillan Press, c1987- |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell*/pathology , Papillomavirus Infections*/complications , Papillomavirus Infections*/genetics , Oropharyngeal Neoplasms*/genetics , Oropharyngeal Neoplasms*/pathology , Head and Neck Neoplasms*, Humans ; Squamous Cell Carcinoma of Head and Neck ; Papillomaviridae/genetics |
| مستخلص: | The incidence of human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) is rising rapidly and has exceeded cervical cancer to become the most common HPV-induced cancer in developed countries. Since patients with HPV + OPSCC respond very favorably to standard aggressive treatment, the emphasis has changed to reducing treatment intensity. However, recent multi-center clinical trials failed to show non-inferiority of de-escalation strategies on a population basis, highlighting the need to select low-risk patients likely to respond to de-intensified treatments. In contrast, there is a substantial proportion of patients who develop recurrent disease despite aggressive therapy. This supports that HPV + OPSCC is not a homogeneous disease, but comprises distinct subtypes with clinical and biological variations. The overall goal for this review is to identify biomarkers for HPV + OPSCC that may be relevant for patient stratification for personalized treatment. We discuss HPV + OPSCC as a heterogeneous disease from multifaceted perspectives including clinical behavior, tumor morphology, and molecular phenotype. Molecular profiling from bulk tumors as well as single-cell sequencing data are discussed as potential driving factors of heterogeneity between tumor subgroups. Finally, we evaluate key challenges that may impede in-depth investigations of HPV + OPSCC heterogeneity and outline potential future directions, including a section on racial and ethnic differences. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | P30 ES017885 United States ES NIEHS NIH HHS; R01 CA250214 United States CA NCI NIH HHS; R35 DE027551 United States DE NIDCR NIH HHS |
| تواريخ الأحداث: | Date Created: 20230904 Date Completed: 20231002 Latest Revision: 20240425 |
| رمز التحديث: | 20240425 |
| مُعرف محوري في PubMed: | PMC10541327 |
| DOI: | 10.1038/s41388-023-02819-y |
| PMID: | 37666939 |
| قاعدة البيانات: | MEDLINE |
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