دورية أكاديمية
Antioxidant and photoprotective role of latex C-serum from Hevea brasiliensis during 15-week UVB irradiation in male hairless SKH-1 mice.
| العنوان: | Antioxidant and photoprotective role of latex C-serum from Hevea brasiliensis during 15-week UVB irradiation in male hairless SKH-1 mice. |
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| المؤلفون: | Kerche LE; Department of Physics, Chemistry and Biology, São Paulo State University, Presidente Prudente, SP, Brazil.; Department of Physiological Sciences, Western São Paulo University, Presidente Prudente, SP, Brazil., Carrara IM; Department of General Pathology, Londrina State University, Londrina, PR, Brazil., Marinello PC; Department of General Pathology, Londrina State University, Londrina, PR, Brazil., Cavalcante DGSM; Department of Physics, Chemistry and Biology, São Paulo State University, Presidente Prudente, SP, Brazil., Danna CS; Department of Physics, Chemistry and Biology, São Paulo State University, Presidente Prudente, SP, Brazil., Cecchini R; Department of General Pathology, Londrina State University, Londrina, PR, Brazil., Cecchini AL; Department of General Pathology, Londrina State University, Londrina, PR, Brazil., Job AE; Department of Physics, Chemistry and Biology, São Paulo State University, Presidente Prudente, SP, Brazil. |
| المصدر: | Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2023 Nov 17; Vol. 86 (22), pp. 846-858. Date of Electronic Publication: 2023 Sep 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 100960995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-7394 (Print) Linking ISSN: 00984108 NLM ISO Abbreviation: J Toxicol Environ Health A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. ; London : Taylor & Francis, c1998- |
| مواضيع طبية MeSH: | Hevea* , Carcinoma, Squamous Cell*, Animals ; Mice ; Antioxidants ; Ultraviolet Rays/adverse effects ; Latex ; Glutathione |
| مستخلص: | It is known that UVB radiation induces several adverse skin alterations starting from simple photoaging to skin cancer. In addition, it was demonstrated that reactive oxygen species (ROS) were found to be related to cancer development and progression. The aim of study was to examine whether male hairless (SKH-1) mice ( Mus musculus ) that were subchronically exposed to UVB radiation presented with actinic keratosis (AK) and squamous cell carcinoma lesions, and that treatment with latex C-serum cream significantly prevented abnormal skin development. Data demonstrated for the first time the photoprotective activity of latex C-serum extracted from the rubber tree Hevea brasiliensis var. subconcolor Ducke. Latex C-serum prevented the progression of AK to squamous cell carcinoma in SKH-1 mice, indicating that mice topically treated with latex C-serum presented only AK lesions and treatment with the highest concentration (10%) significantly reduced epidermal thickness, suggesting diminished cell proliferation. Latex C-serum protected the skin of mice against oxidative stress damage, increasing catalase (CAT) activity, regenerating glutathione (GSH) levels, lowering thiobarbituric acid-reactive species (TBARS) production and regenerating the total antioxidant capacity (TAC) of the skin. Evidence that UV radiation in skin induced systemic alterations and erythrocytic analysis indicated that latex C-serum increased CAT activity and GSH levels. Taken together these data indicate that latex C-serum plays an important antioxidant and photoprotective role, preventing serious damage to the skin following exposure to UVB radiation. |
| فهرسة مساهمة: | Keywords: Hevea brasiliensis; UVB radiation; antioxidant; oxidative stress; squamous cell carcinoma |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Latex) GAN16C9B8O (Glutathione) |
| تواريخ الأحداث: | Date Created: 20230906 Date Completed: 20230913 Latest Revision: 20230920 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/15287394.2023.2255885 |
| PMID: | 37671816 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1528-7394 |
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| DOI: | 10.1080/15287394.2023.2255885 |