دورية أكاديمية
Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes.
العنوان: | Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes. |
---|---|
المؤلفون: | Verçoza BRF; Núcleo Multidisciplinar de Pesquisas em Biologia, NUMPEX-Bio, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil., Bernardo RR; Núcleo Multidisciplinar de Pesquisas em Biologia, NUMPEX-Bio, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil.; Núcleo Multidisciplinar de Pesquisas em Nanotecnologia, NUMPEX-Nano, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil., de Oliveira LAS; Núcleo Multidisciplinar de Pesquisas em Biologia, NUMPEX-Bio, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil.; Núcleo Multidisciplinar de Pesquisas em Nanotecnologia, NUMPEX-Nano, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil., Rodrigues JCF; Núcleo Multidisciplinar de Pesquisas em Biologia, NUMPEX-Bio, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil. |
المصدر: | Beilstein journal of nanotechnology [Beilstein J Nanotechnol] 2023 Aug 30; Vol. 14, pp. 893-903. Date of Electronic Publication: 2023 Aug 30 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Beilstein-Institut zur Förderung der Chemischen Wissenschaften Country of Publication: Germany NLM ID: 101551563 Publication Model: eCollection Cited Medium: Print ISSN: 2190-4286 (Print) Linking ISSN: 21904286 NLM ISO Abbreviation: Beilstein J Nanotechnol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Frankfurt am Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2010, ©2010- |
مستخلص: | The main goal of this work was to evaluate the therapeutic potential of green superparamagnetic iron oxide nanoparticles (SPIONs) produced with coconut water for treating cutaneous leishmaniasis caused by Leishmania amazonensis . Optical and electron microscopy techniques were used to evaluate the effects on cell proliferation, infectivity percentage, and ultrastructure. SPIONs were internalized by both parasite stages, randomly distributed in the cytosol and located mainly in membrane-bound compartments. The selectivity index for intracellular amastigotes was more than 240 times higher compared to current drugs used to treat the disease. The synthesized SPIONs showed promising activity against Leishmania and can be considered a strong candidate for a new therapeutic approach for treating leishmaniases. (Copyright © 2023, Verçoza et al.) |
References: | Int J Nanomedicine. 2016 Sep 12;11:4583-4594. (PMID: 27695319) Sci Pharm. 2017 Nov 20;85(4):. (PMID: 29156612) Clin Microbiol Rev. 2006 Jan;19(1):111-26. (PMID: 16418526) PLoS One. 2017 May 4;12(5):e0177049. (PMID: 28472102) Biotechnol Lett. 2018 Feb;40(2):237-248. (PMID: 29181762) Sci Rep. 2019 Jan 31;9(1):1059. (PMID: 30705309) Biochem Biophys Res Commun. 2015 Dec 18;468(3):511-7. (PMID: 26518648) Acta Trop. 2017 Aug;172:86-90. (PMID: 28460833) Pharm Res. 2016 Oct;33(10):2373-87. (PMID: 27299311) J Antimicrob Chemother. 1994 Feb;33(2):203-13. (PMID: 8182001) Int J Nanomedicine. 2018 Jul 09;13:3965-3973. (PMID: 30022820) Exp Parasitol. 2013 Sep;135(1):153-65. (PMID: 23845259) Biomed Pharmacother. 2001 Jul;55(6):333-9. (PMID: 11478586) J Nutr. 2004 Nov;134(11):3171S-3172S. (PMID: 15514292) Eur J Pharm Sci. 2015 Apr 5;70:125-31. (PMID: 25660615) J Antimicrob Chemother. 2018 Sep 1;73(9):2360-2373. (PMID: 29982734) J Med Chem. 2001 Mar 15;44(6):909-16. (PMID: 11300872) Cell Microbiol. 2008 Feb;10(2):293-300. (PMID: 18070118) Antimicrob Agents Chemother. 2020 Apr 21;64(5):. (PMID: 32152072) J Glob Infect Dis. 2010 May;2(2):167-76. (PMID: 20606973) Nat Nanotechnol. 2011 Jun 26;6(7):418-22. (PMID: 21706024) Nanomedicine (Lond). 2019 Sep;14(17):2293-2313. (PMID: 31414612) Apoptosis. 2017 Sep;22(9):1169-1188. (PMID: 28685254) Trends Parasitol. 2013 Oct;29(10):489-96. (PMID: 23948431) Bioorg Med Chem. 2017 Jun 15;25(12):3034-3045. (PMID: 28433512) Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:1465-1471. (PMID: 28415438) Ultrason Sonochem. 2018 May;43:248-261. (PMID: 29555282) Parasite Epidemiol Control. 2020 May 23;10:e00156. (PMID: 32566773) Eur J Immunol. 2000 Dec;30(12):3732-40. (PMID: 11169417) Curr Opin Microbiol. 2013 Dec;16(6):716-21. (PMID: 23962817) Parasitology. 2010 May;137(6):899-917. (PMID: 20152063) PLoS Negl Trop Dis. 2013;7(2):e2061. (PMID: 23459556) |
فهرسة مساهمة: | Keywords: Leishmania amazonensis; Leishmaniasis; SPIONs; coconut water; nanomedicine |
تواريخ الأحداث: | Date Created: 20230907 Latest Revision: 20230928 |
رمز التحديث: | 20230929 |
مُعرف محوري في PubMed: | PMC10477971 |
DOI: | 10.3762/bjnano.14.73 |
PMID: | 37674544 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2190-4286 |
---|---|
DOI: | 10.3762/bjnano.14.73 |