دورية أكاديمية
Integrins and Actions of Androgen in Breast Cancer.
العنوان: | Integrins and Actions of Androgen in Breast Cancer. |
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المؤلفون: | Tsai CC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan., Yang YSH; Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 11031, Taiwan., Chen YF; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan., Huang LY; Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan., Yang YN; Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan.; School of Medicine, I-Shou University, Kaohsiung 82445, Taiwan., Lee SY; Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei 11031, Taiwan.; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan., Wang WL; Department of Life Science, Fu Jen Catholic University, New Taipei City 242, Taiwan., Lee HL; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan.; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan., Whang-Peng J; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan., Lin HY; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA., Wang K; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan. |
المصدر: | Cells [Cells] 2023 Aug 22; Vol. 12 (17). Date of Electronic Publication: 2023 Aug 22. |
نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مواضيع طبية MeSH: | Androgens*/pharmacology , B7-H1 Antigen*, Male ; Humans ; Endothelial Cells ; Integrin alphaVbeta3 ; Cell Transformation, Neoplastic |
مستخلص: | Androgen has been shown to regulate male physiological activities and cancer proliferation. It is used to antagonize estrogen-induced proliferative effects in breast cancer cells. However, evidence indicates that androgen can stimulate cancer cell growth in estrogen receptor (ER)-positive and ER-negative breast cancer cells via different types of receptors and different mechanisms. Androgen-induced cancer growth and metastasis link with different types of integrins. Integrin αvβ3 is predominantly expressed and activated in cancer cells and rapidly dividing endothelial cells. Programmed death-ligand 1 (PD-L1) also plays a vital role in cancer growth. The part of integrins in action with androgen in cancer cells is not fully mechanically understood. To clarify the interactions between androgen and integrin αvβ3, we carried out molecular modeling to explain the potential interactions of androgen with integrin αvβ3. The androgen-regulated mechanisms on PD-L1 and its effects were also addressed. |
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فهرسة مساهمة: | Keywords: PD-L; androgen; androgen receptor; breast cancer; integrin αvβ3 |
المشرفين على المادة: | 0 (Androgens) 0 (B7-H1 Antigen) 0 (Integrin alphaVbeta3) |
تواريخ الأحداث: | Date Created: 20230908 Date Completed: 20230911 Latest Revision: 20230911 |
رمز التحديث: | 20230912 |
مُعرف محوري في PubMed: | PMC10486718 |
DOI: | 10.3390/cells12172126 |
PMID: | 37681860 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2073-4409 |
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DOI: | 10.3390/cells12172126 |