دورية أكاديمية
Neural plate progenitors give rise to both anterior and posterior pituitary cells.
| العنوان: | Neural plate progenitors give rise to both anterior and posterior pituitary cells. |
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| المؤلفون: | Chen Q; Department of Molecular Cell Biology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel; Department of Molecular Neuroscience, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel., Leshkowitz D; Life Science Core Facilities, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel., Li H; Department of Systems Immunology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel; Present address: CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China., van Impel A; Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, Cells-in-Motion Cluster of Excellence, WWU Münster, Münster, Germany., Schulte-Merker S; Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, Cells-in-Motion Cluster of Excellence, WWU Münster, Münster, Germany., Amit I; Department of Systems Immunology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel., Rizzoti K; Stem Cell Biology and Developmental Genetics Lab, The Francis Crick Institute, London, UK., Levkowitz G; Department of Molecular Cell Biology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel; Department of Molecular Neuroscience, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel. Electronic address: gil.levkowitz@weizmann.ac.il. |
| المصدر: | Developmental cell [Dev Cell] 2023 Dec 04; Vol. 58 (23), pp. 2652-2665.e6. Date of Electronic Publication: 2023 Sep 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press, c2001- |
| مواضيع طبية MeSH: | Pituitary Gland, Posterior*, Mice ; Animals ; Zebrafish ; Neural Plate ; Retinoic Acid 4-Hydroxylase ; Hormones |
| مستخلص: | The pituitary is the master neuroendocrine gland, which regulates body homeostasis. It consists of the anterior pituitary/adenohypophysis harboring hormones producing cells and the posterior pituitary/neurohypophysis, which relays the passage of hormones from the brain to the periphery. It is accepted that the adenohypophysis originates from the oral ectoderm (Rathke's pouch), whereas the neural ectoderm contributes to the neurohypophysis. Single-cell transcriptomics of the zebrafish pituitary showed that cyp26b1-positive astroglial pituicytes of the neurohypophysis and prop1-positive adenohypophyseal progenitors expressed common markers implying lineage relatedness. Genetic tracing identifies that, in contrast to the prevailing dogma, neural plate precursors of zebrafish (her4.3+) and mouse (Sox1+) contribute to both neurohypophyseal and a subset of adenohypophyseal cells. Pituicyte-derived retinoic-acid-degrading enzyme Cyp26b1 fine-tunes differentiation of prop1+ progenitors into hormone-producing cells. These results challenge the notion that adenohypophyseal cells are exclusively derived from non-neural ectoderm and demonstrate that crosstalk between neuro- and adeno-hypophyseal cells affects differentiation of pituitary cells. Competing Interests: Declaration of interests The authors declare no competing interests. (Crown Copyright © 2023. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | MC_U117562207 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: adenohypophysis; astrocytes; embryonic development; hypothalamus; lineage; neuroendocrine; neurohypophysis; pituicyte; radial glia |
| المشرفين على المادة: | EC 1.14.14.1 (Retinoic Acid 4-Hydroxylase) 0 (Hormones) |
| تواريخ الأحداث: | Date Created: 20230908 Date Completed: 20231207 Latest Revision: 20240619 |
| رمز التحديث: | 20240619 |
| DOI: | 10.1016/j.devcel.2023.08.018 |
| PMID: | 37683631 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1878-1551 |
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| DOI: | 10.1016/j.devcel.2023.08.018 |