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Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes.

التفاصيل البيبلوغرافية
العنوان: Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes.
المؤلفون: Llucià-Carol L; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain.; Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain., Muiño E; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain., Cullell N; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain.; Department of Neurology, Hospital Universitari MútuaTerrassa, Fundació Docència i Recerca MútuaTerrassa, 08221 Terrassa, Spain., Cárcel-Márquez J; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain., Lledós M; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain., Gallego-Fabrega C; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain., Martin-Campos J; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain., Martí-Fàbregas J; Department of Neurology, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain., Aguilera-Simón A; Department of Neurology, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain., Planas AM; Institute for Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), 08036 Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., DeDiego ML; Department of Molecular and Cell Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain., de Felipe Mimbrera A; Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón Y Cajal, 28034 Madrid, Spain., Masjuan J; Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón Y Cajal, 28034 Madrid, Spain., García-Madrona S; Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón Y Cajal, 28034 Madrid, Spain., Segura T; Department of Neurology, University Hospital of Albacete, 02006 Albacete, Spain., González-Villar E; Department of Neurology, University Hospital of Albacete, 02006 Albacete, Spain., Serrano-Heras G; Department of Neurology, University Hospital of Albacete, 02006 Albacete, Spain., Domínguez Mayoral A; Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 410113 Seville, Spain.; Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain., Menéndez-Valladares P; Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 410113 Seville, Spain.; Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain., Montaner J; Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 410113 Seville, Spain.; Department of Neurology, Hospital Universitario Virgen Macarena, 41009 Seville, Spain., Migeotte I; Fonds de la Recherche Scientifique (FNRS), 1000 Brussels, Belgium.; Centre de Génétique Humaine, Hopital Erasme, Université Libre de Bruxelles, 1050 Brussels, Belgium., Rahmouni S; Fonds de la Recherche Scientifique (FNRS), 1000 Brussels, Belgium.; Department of Biomedical and Preclinical Sciences, Faculty of Medicine, GIGA-Insitute, University of Liege, 4000 Liège, Belgium., Darcis G; Fonds de la Recherche Scientifique (FNRS), 1000 Brussels, Belgium.; CHU of Liege, 4000 Liège, Belgium., Bernardo D; Mucosal Immunology Lab, Unidad de Excelencia del Instituto de Biomedicina y Genética Molecular (IBGM), Universidad de Valladolid-CSIC, 47005 Valladolid, Spain., Rojo S; Department of Microbiology, Hospital Clínico Universitario de Valladolid, Gerencia Regional de Salud de Castilla y León (SACYL), 47003 Valladolid, Spain., Schulte EC; Institute of Virology, Technical University Munich/Helmholtz Zentrum München, 81377 Munich, Germany.; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich University, 80336 Munich, Germany.; Department of Psychiatry, University Hospital, LMU Munich University, 80336 Munich, Germany.; Institute of Human Genetics, University Hospital Bonn, Medical Faculty, University of Bonn, 53127 Bonn, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Medical Faculty, University of Bonn, 53127 Bonn, Germany., Protzer U; Institute of Virology, Technical University Munich/Helmholtz Zentrum München, 81377 Munich, Germany., Fricke L; Department of Internal Medicine II, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany., Winter C; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technische Universität München (TUM), 81675 Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, Technische Universität München, 81675 Munich, Germany., Niemi MEK; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Cordioli M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland., Delgado P; Department of Neurology, Hospital Universitari de la Vall d'Hebrón, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain., Fernández-Cadenas I; Stroke Pharmacogenomics and Genetics, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 30; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Stroke*/complications , Stroke*/genetics , Brain Ischemia*/complications , Brain Ischemia*/genetics , COVID-19*/complications , COVID-19*/genetics , Ischemic Stroke*/genetics , Embolic Stroke* , Atherosclerosis*, Humans ; Arteries
مستخلص: We aimed to analyse whether patients with ischaemic stroke (IS) occurring within eight days after the onset of COVID-19 (IS-COV) are associated with a specific aetiology of IS. We used SUPERGNOVA to identify genome regions that correlate between the IS-COV cohort (73 IS-COV cases vs. 701 population controls) and different aetiological subtypes. Polygenic risk scores (PRSs) for each subtype were generated and tested in the IS-COV cohort using PRSice-2 and PLINK to find genetic associations. Both analyses used the IS-COV cohort and GWAS from MEGASTROKE (67,162 stroke patients vs. 454,450 population controls), GIGASTROKE (110,182 vs. 1,503,898), and the NINDS Stroke Genetics Network (16,851 vs. 32,473). Three genomic regions were associated ( p -value < 0.05) with large artery atherosclerosis (LAA) and cardioembolic stroke (CES). We found four loci targeting the genes PITX2 (rs10033464, IS-COV beta = 0.04, p -value = 2.3 × 10 -2 , se = 0.02), previously associated with CES, HS6ST1 (rs4662630, IS-COV beta = -0.04, p -value = 1.3 × 10 -3 , se = 0.01), TMEM132E (rs12941838 IS-COV beta = 0.05, p -value = 3.6 × 10 -4 , se = 0.01), and RFFL (rs797989 IS-COV beta = 0.03, p -value = 1.0 × 10 -2 , se = 0.01). A statistically significant PRS was observed for LAA. Our results suggest that IS-COV cases are genetically similar to LAA and CES subtypes. Larger cohorts are needed to assess if the genetic factors in IS-COV cases are shared with the general population or specific to viral infection.
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فهرسة مساهمة: Keywords: COVID-19; GWAS; PRS; ischaemic stroke; local genetic correlation
تواريخ الأحداث: Date Created: 20230909 Date Completed: 20230911 Latest Revision: 20230911
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10487930
DOI: 10.3390/ijms241713452
PMID: 37686257
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms241713452