دورية أكاديمية
أعرض في EDS

Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway.

التفاصيل البيبلوغرافية
العنوان: Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway.
المؤلفون: Wang T; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong 266023, China., Chen X; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong 266023, China., Wang K; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong 266023, China., Ju J; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong 266023, China., Yu X; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong 266023, China., Yu W; College of Medicine, Qingdao University, Qingdao, Shandong 266023, China., Liu C; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong 266023, China., Wang Y; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, Shandong 266023, China.
المصدر: Genes & diseases [Genes Dis] 2023 Mar 24; Vol. 11 (2), pp. 747-759. Date of Electronic Publication: 2023 Mar 24 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V. on behalf of KeAi Communications Co. Ltd Country of Publication: Netherlands NLM ID: 101635967 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-3042 (Electronic) Linking ISSN: 23523042 NLM ISO Abbreviation: Genes Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Amsterdam] : Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
Original Publication: Chongqing, China : Chongqing Medical University, [2014]-
مستخلص: In the mammalian heart, cardiomyocytes are forced to withdraw from the cell cycle shortly after birth, limiting the ability of the heart to regenerate and repair. The development of multimodal regulation of cardiac proliferation has verified that pre-existing cardiomyocyte proliferation is an essential driver of cardiac renewal. With the continuous development of genetic lineage tracking technology, it has been revealed that cell cycle activity produces polyploid cardiomyocytes during the embryonic, juvenile, and adult stages of cardiogenesis, but newly formed mononucleated diploid cardiomyocytes also elevated sporadically during myocardial infarction. It implied that adult cardiomyocytes have a weak regenerative capacity under the condition of ischemia injury, which offers hope for the clinical treatment of myocardial infarction. However, the regeneration frequency and source of cardiomyocytes are still low, and the mechanism of regulating cardiomyocyte proliferation remains further explained. It is noteworthy to explore what force triggers endogenous cardiomyocyte proliferation and heart regeneration. Here, we focused on summarizing the recent research progress of emerging endogenous key modulators and crosstalk with other signaling pathways and furnished valuable insights into the internal mechanism of heart regeneration. In addition, myocardial transcription factors, non-coding RNAs, cyclins, and cell cycle-dependent kinases are involved in the multimodal regulation of pre-existing cardiomyocyte proliferation. Ultimately, awakening the myocardial proliferation endogenous modulator and regeneration pathways may be the final battlefield for the regenerative therapy of cardiovascular diseases.
(© 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.)
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فهرسة مساهمة: Keywords: Cardiac regeneration; Cell cycle re-enter; Myocardial infarction; Pre-existing cardiomyocyte proliferation; Regenerative therapy of cardiovascular diseases
تواريخ الأحداث: Date Created: 20230911 Latest Revision: 20230913
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10491875
DOI: 10.1016/j.gendis.2023.01.031
PMID: 37692487
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-3042
DOI:10.1016/j.gendis.2023.01.031