دورية أكاديمية
أعرض في EDS

Association between anti-endothelial antigen antibodies and allograft rejection in kidney transplantation.

التفاصيل البيبلوغرافية
العنوان: Association between anti-endothelial antigen antibodies and allograft rejection in kidney transplantation.
المؤلفون: Lee HJ; Department of Laboratory Medicine, Pusan National University School of Medicine, Yangsan, Korea.; Transplant Research Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea., Shin KH; Department of Laboratory Medicine, Pusan National University School of Medicine, Yangsan, Korea., Kim IY; Transplant Research Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea., Choi BH; Transplant Research Center, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.; Department of Surgery, Pusan National University School of Medicine, Yangsan, Korea., Kim HH; BioMedical Informatics Unit, Pusan National University School of Medicine, Busan, Korea.
المصدر: Journal of clinical laboratory analysis [J Clin Lab Anal] 2023 Aug; Vol. 37 (15-16), pp. e24961. Date of Electronic Publication: 2023 Sep 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8801384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2825 (Electronic) Linking ISSN: 08878013 NLM ISO Abbreviation: J Clin Lab Anal Subsets: MEDLINE
أسماء مطبوعة: Publication: Hoboken, N.J. : Wiley
Original Publication: New York : Alan R. Liss, Inc., c1987-
مواضيع طبية MeSH: Kidney Transplantation*/adverse effects, Humans ; Endothelial Cells ; Transplantation, Homologous ; Antibodies ; HLA Antigens ; Graft Rejection ; Allografts
مستخلص: Background: Endothelial cells are vital in the transplant immune system as semiprofessional antigen-presenting cells. Few studies have investigated the importance of anti-endothelin subtype A receptor (ETAR) antibodies in kidney transplantation. Here, we aimed to analyze the association between anti-angiotensin II type I receptor (AT1R) and anti-ETAR antibodies and the association between the presence of anti-endothelial antibodies and the risk of allograft rejection in kidney transplantation.
Methods: In total, 252 patients who underwent kidney transplantation were enrolled in this study. Antibodies for human leukocyte antigens (HLAs) and non-HLAs were analyzed immediately before transplantation. Patients were categorized based on the occurrence of antibody-mediated rejection (AMR) or T-cell-mediated rejection (TCMR) by 2017 Banff classification. All p-values were two-tailed, and statistical significance was set at p < 0.05.
Results: Patients with anti-AT1R antibodies had a 3.49-fold higher risk of TCMR than those without anti-AT1R antibodies. Patients with anti-ETAR antibodies had a 5.84-fold higher risk of AMR than those without anti-ETAR antibodies. The hazard ratio of AMR in patients with both HLA DSAs and anti-ETAR antibodies, relative to patients without anti-ETAR antibodies and HLA DSAs, was 32.85 (95% CI = 1.82-592.91).
Conclusion: Our findings indicated that anti-ETAR antibodies are associated with AMR, and patients with both anti-ETAR antibodies and de novo HLA DSAs were at a high risk of AMR.
(© 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)
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معلومات مُعتمدة: 30-2022-015 Research Institute for Convergence Biomedical Science and Technology, Pusan National University Yangsan Hospital
فهرسة مساهمة: Keywords: T-cell-mediated rejection; allograft rejection; anti-endothelial antigen antibodies; antibody-mediated rejection; donor-specific antibodies; kidney transplantation
المشرفين على المادة: 0 (Antibodies)
0 (HLA Antigens)
تواريخ الأحداث: Date Created: 20230911 Date Completed: 20231010 Latest Revision: 20231018
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10561590
DOI: 10.1002/jcla.24961
PMID: 37694947
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-2825
DOI:10.1002/jcla.24961