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Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes.

التفاصيل البيبلوغرافية
العنوان: Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes.
المؤلفون: Carey ME; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.; IAVI, Chelsea & Westminster Hospital, London, United Kingdom., Dyson ZA; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Ingle DJ; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia., Amir A; National Institute of Health, Islamabad, Pakistan., Aworh MK; Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria.; College of Veterinary Medicine, North Carolina State University, Raleigh, United States., Chattaway MA; United Kingdom Health Security Agency, London, United Kingdom., Chew KL; National University Hospital, Singapore, Singapore., Crump JA; Centre for International Health, University of Otago, Dunedin, New Zealand., Feasey NA; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.; Malawi-Liverpool Wellcome Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Howden BP; Centre for Pathogen Genomics, Department of Microbiology and Immunology, University of Melbourne at Doherty Institute for Infection and Immunity, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Keddy KH; Independent consultant, Johannesburg, South Africa., Maes M; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Parry CM; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom., Van Puyvelde S; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.; University of Antwerp, Antwerp, Belgium., Webb HE; Centers for Disease Control and Prevention, Atlanta, United States., Afolayan AO; Global Health Research Unit (GHRU) for the Genomic Surveillance of Antimicrobial Resistance, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria., Alexander AP; Lady Willingdon Hospital, Manali, India., Anandan S; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Andrews JR; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, United States., Ashton PM; Malawi-Liverpool Wellcome Programme, Blantyre, Malawi.; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Basnyat B; Oxford University Clinical Research Unit Nepal, Kathmandu, Nepal., Bavdekar A; KEM Hospital Research Centre, Pune, India., Bogoch II; Department of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Canada., Clemens JD; International Vaccine Institute, Seoul, Republic of Korea.; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.; UCLA Fielding School of Public Health, Los Angeles, United States.; Korea University, Seoul, Republic of Korea., da Silva KE; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, United States., De A; Topiwala National Medical College, Mumbai, India., de Ligt J; ESR, Institute of Environmental Science and Research Ltd., Porirua, Wellington, New Zealand., Diaz Guevara PL; Grupo de Microbiologia, Instituto Nacional de Salud, Bogota, Colombia., Dolecek C; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand., Dutta S; ICMR - National Institute of Cholera & Enteric Diseases, Kolkata, India., Ehlers MM; Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Medical Microbiology, Tshwane Academic Division, National Health Laboratory Service, Pretoria, South Africa., Francois Watkins L; Centers for Disease Control and Prevention, Atlanta, United States., Garrett DO; Sabin Vaccine Institute, Washington DC, United States., Godbole G; United Kingdom Health Security Agency, London, United Kingdom., Gordon MA; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Greenhill AR; Federation University Australia, Churchill, Australia.; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea., Griffin C; Centers for Disease Control and Prevention, Atlanta, United States., Gupta M; Post Graduate Institute of Medical Education and Research, Chandigarh, India., Hendriksen RS; Technical University of Denmark, Copenhagen, Denmark., Heyderman RS; Research Department of Infection, Division of Infection and Immunity, University College London, London, United Kingdom., Hooda Y; Child Health Research Foundation, Dhaka, Bangladesh., Hormazabal JC; Bacteriologia, Subdepartamento de Enfermedades Infecciosas, Departamento de Laboratorio Biomedico, Instituto de Salud Publica de Chile (ISP), Santiago, Chile., Ikhimiukor OO; Global Health Research Unit (GHRU) for the Genomic Surveillance of Antimicrobial Resistance, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria., Iqbal J; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan., Jacob JJ; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Jenkins C; United Kingdom Health Security Agency, London, United Kingdom., Jinka DR; Rural Development Trust Hospital, Anantapur, India., John J; Department of Community Health, Christian Medical College, Vellore, India., Kang G; Department of Community Health, Christian Medical College, Vellore, India., Kanteh A; Medical Research Council Unit The Gambia at London School Hygiene & Tropical Medicine, Fajara, Gambia., Kapil A; All India Institute of Medical Sciences, Delhi, India., Karkey A; Oxford University Clinical Research Unit Nepal, Kathmandu, Nepal., Kariuki S; Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya., Kingsley RA; Quadram Institute Bioscience, Norwich, United Kingdom., Koshy RM; Makunda Christian Hospital, Assam, India., Lauer AC; Centers for Disease Control and Prevention, Atlanta, United States., Levine MM; Center for Vaccine Development and Global Health (CVD), University of Maryland School of Medicine, Baltimore, Maryland, USA, Baltimore, United States., Lingegowda RK; Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India., Luby SP; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, United States., Mackenzie GA; Medical Research Council Unit The Gambia at London School Hygiene & Tropical Medicine, Fajara, Gambia., Mashe T; National Microbiology Reference Laboratory, Harare, Zimbabwe.; World Health Organization, Harare, Zimbabwe., Msefula C; Kamuzu University of Health Sciences, Blantyre, Malawi., Mutreja A; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Nagaraj G; Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India., Nagaraj S; Saint Johns Medical College and Hospital, Bengaluru, India., Nair S; United Kingdom Health Security Agency, London, United Kingdom., Naseri TK; Ministry of Health, Government of Samoa, Apia, Samoa., Nimarota-Brown S; Ministry of Health, Government of Samoa, Apia, Samoa., Njamkepo E; Institut Pasteur, Université Paris Cité, Paris, France., Okeke IN; Global Health Research Unit (GHRU) for the Genomic Surveillance of Antimicrobial Resistance, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria., Perumal SPB; Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; The NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom., Pragasam AK; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Qadri F; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Qamar FN; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan., Rahman SIA; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Rambocus SD; Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Rasko DA; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, United States., Ray P; Post Graduate Institute of Medical Education and Research, Chandigarh, India., Robins-Browne R; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia., Rongsen-Chandola T; Centre for Health Research and Development, Society for Applied Studies, Delhi, India., Rutanga JP; University of Rwanda, College of Science and Technology, Kigali, Rwanda., Saha SK; Child Health Research Foundation, Dhaka, Bangladesh., Saha S; Child Health Research Foundation, Dhaka, Bangladesh., Saigal K; Chacha Nehru Bal Chikitsalaya, Delhi, India., Sajib MSI; Child Health Research Foundation, Dhaka, Bangladesh.; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, United Kingdom., Seidman JC; Sabin Vaccine Institute, Washington DC, United States., Shakya J; Dhulikhel Hospital, Dhulikhel, Nepal.; Institute for Research in Science and Technology, Kathmandu, Nepal., Shamanna V; Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India., Shastri J; Topiwala National Medical College, Mumbai, India.; Kasturba Hospital for Infectious Diseases, Mumbai, India., Shrestha R; Center for Infectious Disease Research & Surveillance, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Nepal., Sia S; Research Institute for Tropical Medicine, Department of Health, Muntinlupa City, Philippines., Sikorski MJ; Center for Vaccine Development and Global Health (CVD), University of Maryland School of Medicine, Baltimore, Maryland, USA, Baltimore, United States.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, United States., Singh A; Chinchpada Christian Hospital, Navapur, India., Smith AM; Centre for Enteric Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa., Tagg KA; Centers for Disease Control and Prevention, Atlanta, United States., Tamrakar D; Center for Infectious Disease Research & Surveillance, Dhulikhel Hospital, Kathmandu University Hospital, Dhulikhel, Nepal., Tanmoy AM; Child Health Research Foundation, Dhaka, Bangladesh., Thomas M; Christian Medical College, Ludhiana, Ludhiana, India., Thomas MS; Duncan Hospital, Raxaul, India., Thomsen R; Ministry of Health, Government of Samoa, Apia, Samoa., Thomson NR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Tupua S; Ministry of Health, Government of Samoa, Apia, Samoa., Vaidya K; University of California Davis, Davis, United States., Valcanis M; Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Veeraraghavan B; Department of Clinical Microbiology, Christian Medical College, Vellore, India., Weill FX; Institut Pasteur, Université Paris Cité, Paris, France., Wright J; ESR, Institute of Environmental Science and Research Ltd., Porirua, Wellington, New Zealand., Dougan G; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Argimón S; Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom., Keane JA; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom., Aanensen DM; Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom., Baker S; Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.; IAVI, Chelsea & Westminster Hospital, London, United Kingdom., Holt KE; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia.
مؤلفون مشاركون: Global Typhoid Genomics Consortium Group Authorship
المصدر: ELife [Elife] 2023 Sep 12; Vol. 12. Date of Electronic Publication: 2023 Sep 12.
نوع المنشور: Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Salmonella typhi*/genetics , Typhoid Fever*/epidemiology, Humans ; Anti-Bacterial Agents/pharmacology ; Travel ; Drug Resistance, Bacterial/genetics ; Ciprofloxacin
مستخلص: Background: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000).
Methods: This is a meta-analysis of global genotype and antimicrobial resistance (AMR) determinants extracted from previously sequenced genome data and analysed using consistent methods implemented in open analysis platforms GenoTyphi and Pathogenwatch.
Results: Compared with previous global snapshots, the data highlight that genotype 4.3.1 (H58) has not spread beyond Asia and Eastern/Southern Africa; in other regions, distinct genotypes dominate and have independently evolved AMR. Data gaps remain in many parts of the world, and we show the potential of travel-associated sequences to provide informal 'sentinel' surveillance for such locations. The data indicate that ciprofloxacin non-susceptibility (>1 resistance determinant) is widespread across geographies and genotypes, with high-level ciprofloxacin resistance (≥3 determinants) reaching 20% prevalence in South Asia. Extensively drug-resistant (XDR) typhoid has become dominant in Pakistan (70% in 2020) but has not yet become established elsewhere. Ceftriaxone resistance has emerged in eight non-XDR genotypes, including a ciprofloxacin-resistant lineage (4.3.1.2.1) in India. Azithromycin resistance mutations were detected at low prevalence in South Asia, including in two common ciprofloxacin-resistant genotypes.
Conclusions: The consortium's aim is to encourage continued data sharing and collaboration to monitor the emergence and global spread of AMR Typhi, and to inform decision-making around the introduction of typhoid conjugate vaccines (TCVs) and other prevention and control strategies.
Funding: No specific funding was awarded for this meta-analysis. Coordinators were supported by fellowships from the European Union (ZAD received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 845681), the Wellcome Trust (SB, Wellcome Trust Senior Fellowship), and the National Health and Medical Research Council (DJI is supported by an NHMRC Investigator Grant [GNT1195210]).
Competing Interests: MC, ZD, DI, AA, MA, MC, KC, JC, BH, KK, MM, CP, SV, HW, AA, AA, SA, JA, PA, BB, AB, JC, Kd, AD, Jd, PD, CD, SD, ME, LF, DG, GG, MG, AG, CG, MG, RH, RH, YH, JH, OI, JI, JJ, CJ, DJ, JJ, GK, AK, AK, AK, SK, RK, RK, AL, ML, RL, SL, GM, TM, CM, AM, GN, SN, SN, TN, SN, EN, IO, SP, AP, FQ, FQ, SR, SR, DR, PR, RR, TR, JR, SS, SS, KS, MS, JS, JS, VS, JS, RS, SS, MS, AS, AS, KT, DT, AT, MT, MT, RT, NT, ST, KV, MV, BV, FW, JW, GD, SA, JK, DA, SB, KH No competing interests declared, NF NAF chairs the Wellcome Surveillance and Epidemiology of Drug Resistant Infections (SEDRIC) group, which has a focus on antimicrobial resistance. This could be perceived as relevant although not a direct conflict, IB IB has consulted to BlueDot and the NHL Players' Association, AP AJP is chair of the UK Department of Health and Social Care's (DHSC) Joint Committee on Vaccination and Immunisation (JCVI) but does not take part in the JCVI COVID-19 committee. He was a member of WHO SAGE until 2022. AJPs employer, Oxford University has entered into a partnership with AstraZeneca for development of a COVID-19 vaccine. AJP has provided advice to Shionogi & Co., Ltd on development of a COVID19 vaccine
(© 2023, Carey et al.)
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معلومات مُعتمدة: BBS/E/F/00PR10348 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; U19 AI110820 United States AI NIAID NIH HHS; F30 AI156973 United States AI NIAID NIH HHS; BB/R012504/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; R01 TW009237 United States TW FIC NIH HHS; U01 AI062563 United States AI NIAID NIH HHS; MR/TOO5033/1 United Kingdom MRC_ Medical Research Council; 206545/7/17/Z United Kingdom WT_ Wellcome Trust; 106158/7/14/Z United Kingdom WT_ Wellcome Trust; R01 AI099525 United States AI NIAID NIH HHS; 001 International WHO_ World Health Organization; R01 AI121378 United States AI NIAID NIH HHS; 206194 United Kingdom WT_ Wellcome Trust; MR/L00464X/ United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Investigator: P Aaby, Bandim Health Project, Guinea-Bissau, Guinea-Bissau.; A Abbas, Department of Microbiology, Faculty of Veterinary Medicine, University of Kufa, Najaf, Iraq.; N Ahmed, University of Hyderabad, Hyderabad, India.; S Andleeb, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.; A Aseffa, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.; KS Baker, University of Liverpool, Liverpool, United Kingdom.; A Bentsi-Enchill, World Health Organization, Geneva, Switzerland.; RF Breiman, Emory University, Atlanta, United States.; C Britto, Boston Children's Hospital, Boston, United States.; J Campos, INEI-ANLIS 'Dr Carlos G. Malbrán', Buenos Aires, Argentina.; CJ Chen, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; CS Chiou, Centers for Disease Control, Taipei, Taiwan.; V Davong, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic.; A Faiz, Dev Care Foundation, Dhaka, Bangladesh.; D Gul, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.; R Hasan, Aga Khan University, Karachi, Pakistan.; M Hatta, Department of Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.; A Ikram, National Institute of Health, Islamabad, Pakistan.; L Isaia, Ministry of Health, Government of Samoa, Apia, Samoa.; J Jacobs, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; S Kariuki, Malaria Branch, Kenya Medical Research Institute (KEMRI) Centre for Global Health Research, Kisumu, Kenya.; F Khokhar, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.; E Klemm, Novo Nordisk Foundation, Hellerup, Denmark.; LMF Kuijpers, Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.; G Langridge, Quadram Institute Bioscience, Norwich, United Kingdom.; K Lim, Sihanouk Hospital Center of HOPE, Phnom Penh, Cambodia.; O Lunguya, Department of Microbiology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Department of Medical Biology, University Teaching Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo.; F Luquero, Global Alliance for Vaccines and Immunization (GAVI), Geneva, Switzerland.; CA MacLennan, Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; F Marks, International Vaccine Institute, Seoul, Republic of Korea.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Madagascar Institute for Vaccine Research, University of Antananarivo, Antananarivo, Madagascar.; Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.; M Morita, National Institute of Infectious Diseases, Tokyo, Japan.; M Muchimba, Centre of Infectious Disease Research in Zambia, Lusaka, Zambia.; JCL Mwansa, Lusaka Apex Medical University, Lusaka, Zambia.; K Mwape, Centre of Infectious Disease Research in Zambia, Lusaka, Zambia.; Water and Health Research Center, Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa.; Department of Basic Medical Sciences, Michael Chilufya Sata School of Medicine, Copperbelt University, Ndola, Zambia.; JM Mwenda, World Health Organization (WHO) Regional Office for Africa, Immunization and Vaccines Development, Brazzaville, Democratic Republic of the Congo.; J Nash, National Microbiology Laboratory, Public Health Agency of Canada, Toronto, Canada.; KM Neuzil, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Baltimore, United States.; P Newton, Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; S Obaro, University of Nebraska Medical Center, Omaha, United States.; International Foundation Against Infectious Diseases in Nigeria, Abuja, Nigeria.; S Octavia, Environmental Health Institute, National Environment Agency, Singapore, Singapore.; M Ohnishi, National Institute of Infectious Diseases, Tokyo, Japan.; M Owusu, Department of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.; E Owusu-Dabo, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.; SE Park, International Vaccine Institute, Seoul, Republic of Korea.; Yonsei University Graduate School of Public Health, Seoul, Republic of Korea.; J Parkhill, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.; DT Pham, Oxford University Clinical Research Unit, Ho Chi Minh, Viet Nam.; MF Phoba, Department of Microbiology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; DJ Pickard, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.; R Rakotozandrindrainy, Madagascar Institute for Vaccine Research, University of Antananarivo, Antananarivo, Madagascar.; P Ramon-Pardo, Pan American Health Organization, AMR Special Program, Washington, United Kingdom.; F Rasheed, Allama Iqbal Medical College, Lahore, Pakistan.; A Rokney, Ministry of Health, Jerusalem, Israel.; P Rupali, Department of Infectious Diseases, Christian Medical College, Vellore, India.; R Sah, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal.; S Shakoor, Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.; London School of Hygiene & Tropical Medicine, London, United Kingdom.; M Simuyand, Center of Infectious Disease Research in Zambia, Lusaka, Zambia.; A Sooka, National Institute for Communicable Diseases, Johannesburg, South Africa.; JD Stanaway, Institute for Health Metrics and Evaluation, University of Washingto, Washington, United States.; AD Steele, Enteric and Diarrheal Diseases, Bill & Melinda Gates Foundation, Seattle, United States.; B Tack, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.; A Tall, Institut Pasteur, Dakar, Senegal.; N Taneja, Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.; M Teferi, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.; S Tessema, Africa Centres for Disease Prevention and Control, Addis Ababa, Ethiopia.; G Thilliez, Quadram Institute Bioscience, Norwich, United Kingdom.; P Turner, Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.; JE Ussher, University of Otago, Dunedin, New Zealand.; AM Villanueva, National Reference Laboratory for HIV/AIDS, Hepatitis, and Other Sexually-Transmitted Infections, San Lazaro Hospital, Manila, Philippines.; B Weimer, Department of Population Health and Reproduction, 100K Pathogen Genome Consortium, School of Veterinary Medicine, UC Davis, Davis, United States.; VK Wong, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.; RC Founou, Department of Microbiology, Immunology and Haematology, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.; Antimicrobial Resistance and Infectious Diseases Unit, Research Institute of Centre of Expertise and Biological Diagnostic of Cameroon (CEDBCAM-RI), Dschang, Cameroon.
Keywords: S. enterica serovar typhi; antimicrobial resistance; epidemiology; genomics; global health; infectious disease; microbiology; typhoid conjugate vaccine; typhoid fever
Local Abstract: [plain-language-summary] Salmonella Typhi (Typhi) is a type of bacteria that causes typhoid fever. More than 110,000 people die from this disease each year, predominantly in areas of sub-Saharan Africa and South Asia with limited access to safe water and sanitation. Clinicians use antibiotics to treat typhoid fever, but scientists worry that the spread of antimicrobial-resistant Typhi could render the drugs ineffective, leading to increased typhoid fever mortality. The World Health Organization has prequalified two vaccines that are highly effective in preventing typhoid fever and may also help limit the emergence and spread of resistant Typhi. In low resource settings, public health officials must make difficult trade-off decisions about which new vaccines to introduce into already crowded immunization schedules. Understanding the local burden of antimicrobial-resistant Typhi and how it is spreading could help inform their actions. The Global Typhoid Genomics Consortium analyzed 13,000 Typhi genomes from 110 countries to provide a global overview of genetic diversity and antimicrobial-resistant patterns. The analysis showed great genetic diversity of the different strains between countries and regions. For example, the H58 Typhi variant, which is often drug-resistant, has spread rapidly through Asia and Eastern and Southern Africa, but is less common in other regions. However, distinct strains of other drug-resistant Typhi have emerged in other parts of the world. Resistance to the antibiotic ciprofloxacin was widespread and accounted for over 85% of cases in South Africa. Around 70% of Typhi from Pakistan were extensively drug-resistant in 2020, but these hard-to-treat variants have not yet become established elsewhere. Variants that are resistant to both ciprofloxacin and ceftriaxone have been identified, and azithromycin resistance has also appeared in several different variants across South Asia. The Consortium’s analyses provide valuable insights into the global distribution and transmission patterns of drug-resistant Typhi. Limited genetic data were available fromseveral regions, but data from travel-associated cases helped fill some regional gaps. These findings may help serve as a starting point for collective sharing and analyses of genetic data to inform local public health action. Funders need to provide ongoing supportto help fill global surveillance data gaps.
المشرفين على المادة: 0 (Anti-Bacterial Agents)
5E8K9I0O4U (Ciprofloxacin)
تواريخ الأحداث: Date Created: 20230912 Date Completed: 20230913 Latest Revision: 20240924
رمز التحديث: 20240924
مُعرف محوري في PubMed: PMC10506625
DOI: 10.7554/eLife.85867
PMID: 37697804
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.85867