دورية أكاديمية
أعرض في EDS

Calorie restriction outperforms bariatric surgery in a murine model of obesity and triple-negative breast cancer.

التفاصيل البيبلوغرافية
العنوان: Calorie restriction outperforms bariatric surgery in a murine model of obesity and triple-negative breast cancer.
المؤلفون: Camp KK; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Coleman MF; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., McFarlane TL; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Doerstling SS; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Khatib SA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Rezeli ET; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Lewis AG; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Pfeil AJ; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Smith LA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Bowers LW; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Fouladi F; College of Computing and Informatics, University of North Carolina at Charlotte, Charlotte, North Carolina, USA., Gong W; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Glenny EM; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Parker JS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Milne GL; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Carroll IM; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Fodor AA; College of Computing and Informatics, University of North Carolina at Charlotte, Charlotte, North Carolina, USA., Seeley RJ; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Hursting SD; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
المصدر: JCI insight [JCI Insight] 2023 Sep 12; Vol. 8 (19). Date of Electronic Publication: 2023 Sep 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]-
مواضيع طبية MeSH: Triple Negative Breast Neoplasms* , Bariatric Surgery*, Humans ; Mice ; Animals ; Caloric Restriction ; Disease Models, Animal ; Obesity/complications ; Obesity/surgery
مستخلص: Obesity promotes triple-negative breast cancer (TNBC), and effective interventions are urgently needed to break the obesity-TNBC link. Epidemiologic studies indicate that bariatric surgery reduces TNBC risk, while evidence is limited or conflicted for weight loss via low-fat diet (LFD) or calorie restriction (CR). Using a murine model of obesity-driven TNBC, we compared the antitumor effects of vertical sleeve gastrectomy (VSG) with LFD, chronic CR, and intermittent CR. Each intervention generated weight and fat loss and suppressed tumor growth relative to obese mice (greatest suppression with CR). VSG and CR regimens exerted both similar and unique effects, as assessed using multiomics approaches, in reversing obesity-associated transcript, epigenetics, secretome, and microbiota changes and restoring antitumor immunity. Thus, in a murine model of TNBC, bariatric surgery and CR each reverse obesity-driven tumor growth via shared and distinct antitumor mechanisms, and CR is superior to VSG in reversing obesity's procancer effects.
References: Elife. 2022 Jul 01;11:. (PMID: 35775614)
Surg Obes Relat Dis. 2020 Oct;16(10):1586-1595. (PMID: 32737010)
Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
J Exp Med. 2022 Mar 7;219(3):. (PMID: 35103755)
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283)
Cancer Metastasis Rev. 2022 Sep;41(3):607-625. (PMID: 35752704)
Science. 2018 Jan 5;359(6371):97-103. (PMID: 29097493)
Bioinformatics. 2011 Jun 1;27(11):1571-2. (PMID: 21493656)
Diabetes. 2013 Jul;62(7):2380-5. (PMID: 23434938)
Behav Sci (Basel). 2017 Jan 19;7(1):. (PMID: 28106818)
ISME J. 2017 Sep;11(9):2047-2058. (PMID: 28548658)
Trends Cell Biol. 2017 Jun;27(6):417-429. (PMID: 28237661)
Science. 2021 Feb 5;371(6529):602-609. (PMID: 33303685)
Front Oncol. 2023 Jan 04;12:1031174. (PMID: 36686775)
Mol Metab. 2023 Mar;69:101686. (PMID: 36746333)
NCHS Data Brief. 2020 Feb;(360):1-8. (PMID: 32487284)
Nutr Rev. 2021 Mar 9;79(4):429-444. (PMID: 32885229)
Obes Surg. 2014 Mar;24(3):437-55. (PMID: 24374842)
Bioinformatics. 2019 Jun 1;35(11):1958-1959. (PMID: 30346483)
Lancet Oncol. 2009 Jul;10(7):653-62. (PMID: 19556163)
J Clin Oncol. 2016 Dec 10;34(35):4270-4276. (PMID: 27903155)
Endocrinology. 2021 Sep 1;162(9):. (PMID: 34190328)
J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1107-13. (PMID: 19638417)
J Clin Endocrinol Metab. 2022 Jul 14;107(8):2154-2166. (PMID: 35453151)
Front Surg. 2022 Jul 15;9:918272. (PMID: 35910464)
Obesity (Silver Spring). 2022 Jan;30(1):28-38. (PMID: 34932888)
Cancer Prev Res (Phila). 2022 Sep 1;15(9):581-594. (PMID: 35696725)
Br J Cancer. 2021 Mar;124(6):1049-1056. (PMID: 33235315)
Dis Model Mech. 2021 Apr 1;14(4):. (PMID: 33653826)
Front Immunol. 2020 Oct 06;11:590794. (PMID: 33123173)
Nat Protoc. 2019 Feb;14(2):482-517. (PMID: 30664679)
Gut. 2019 Jan;68(1):70-82. (PMID: 29899081)
Nucleic Acids Res. 2021 Jan 8;49(D1):D325-D334. (PMID: 33290552)
Cell Syst. 2015 Dec 23;1(6):417-425. (PMID: 26771021)
Gut Microbes. 2022 Jan-Dec;14(1):2050636. (PMID: 35316158)
Surgery. 2021 Jul;170(1):13-17. (PMID: 33714616)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Curr Obes Rep. 2019 Sep;8(3):229-242. (PMID: 31197613)
Obes Surg. 2019 Mar;29(3):782-795. (PMID: 30421326)
Obes Surg. 2021 Jul;31(7):3165-3176. (PMID: 33963974)
Genome Biol. 2012 Oct 03;13(10):R87. (PMID: 23034086)
Lancet. 2016 Aug 27;388(10047):849-51. (PMID: 27597452)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Diabetologia. 2018 Feb;61(2):257-264. (PMID: 29224190)
Front Oncol. 2021 Mar 30;11:638918. (PMID: 33859943)
Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E641-8. (PMID: 23880309)
Cancer Prev Res (Phila). 2016 May;9(5):339-48. (PMID: 26869351)
Nat Med. 2019 Jan;25(1):141-151. (PMID: 30420753)
Cancer Prev Res (Phila). 2022 Aug 1;15(8):481-495. (PMID: 35653548)
Diabetologia. 2016 May;59(5):945-53. (PMID: 26983924)
Science. 2015 Nov 27;350(6264):1079-84. (PMID: 26541610)
Cancer Metastasis Rev. 2022 Sep;41(3):673-695. (PMID: 35870055)
Obes Surg. 2019 Apr;29(4):1259-1267. (PMID: 30604078)
Nat Protoc. 2020 Mar;15(3):799-821. (PMID: 31942082)
Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943)
Front Immunol. 2020 Oct 16;11:571731. (PMID: 33178196)
Nat Methods. 2017 Apr;14(4):417-419. (PMID: 28263959)
Microbiome. 2022 Apr 4;10(1):57. (PMID: 35379337)
JAMA. 2022 Jun 28;327(24):2423-2433. (PMID: 35657620)
Cancer Immunol Res. 2020 Oct;8(10):1243-1250. (PMID: 32847937)
معلومات مُعتمدة: P30 DK089503 United States DK NIDDK NIH HHS; R35 CA197627 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Breast cancer; Metabolism; Obesity; Oncology
تواريخ الأحداث: Date Created: 20230912 Date Completed: 20231109 Latest Revision: 20240806
رمز التحديث: 20240806
مُعرف محوري في PubMed: PMC10629811
DOI: 10.1172/jci.insight.172868
PMID: 37698918
قاعدة البيانات: MEDLINE
الوصف
تدمد:2379-3708
DOI:10.1172/jci.insight.172868