دورية أكاديمية
Breed-specific evaluation of serum biochemical markers in canine hip dysplasia observed in a Tornjak dog population.
| العنوان: | Breed-specific evaluation of serum biochemical markers in canine hip dysplasia observed in a Tornjak dog population. |
|---|---|
| المؤلفون: | Alilovic I; Department of Basic Veterinary Sciences, University of Sarajevo - Veterinary Faculty, Sarajevo, Bosnia and Herzegovina., Rukavina D; Department of Basic Veterinary Sciences, University of Sarajevo - Veterinary Faculty, Sarajevo, Bosnia and Herzegovina., Ajanovic A; Department of Basic Veterinary Sciences, University of Sarajevo - Veterinary Faculty, Sarajevo, Bosnia and Herzegovina., Eterovic T; Laboratoty of Virology, Veterinary Institute, Sarajevo, Bosnia and Herzegovina., Milosevic H; Department of Clinical Sciences of Veterinary Medicine, University of Sarajevo - Veterinary Faculty, Sarajevo, Bosnia and Herzegovina., Ohran H; Department of Basic Veterinary Sciences, University of Sarajevo - Veterinary Faculty, Sarajevo, Bosnia and Herzegovina., Zahirovic A; Department of Clinical Sciences of Veterinary Medicine, University of Sarajevo - Veterinary Faculty, Sarajevo, Bosnia and Herzegovina. |
| المصدر: | American journal of veterinary research [Am J Vet Res] 2023 Sep 16; Vol. 84 (11). Date of Electronic Publication: 2023 Sep 16 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 0375011 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1943-5681 (Electronic) Linking ISSN: 00029645 NLM ISO Abbreviation: Am J Vet Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Schaumburg, Ill. : American Veterinary Medical Association Original Publication: Chicago : American Veterinary Medical Assn. |
| مواضيع طبية MeSH: | Hip Dysplasia, Canine*/diagnostic imaging , Hip Dislocation*/veterinary , Dog Diseases*/diagnostic imaging, Dogs ; Animals ; Matrix Metalloproteinase 9 ; Biomarkers ; Hip Joint |
| مستخلص: | Objective: Canine hip dysplasia (CHD) is a global disease and an improved diagnostic approach to this orthopedic condition is needed, with an emphasis on inexpensive and minimally invasive techniques. This research aimed to determine the differentiating potential of selected biochemical markers in serum between healthy dogs and dogs with hip dysplasia in a breed-specific study that involved the Tornjak dog population. Animals: 99 Tornjak dogs radiographically categorized (Federation Cynologique Internationale procedure and scoring scheme) between December 2019 and April 2021, as having no sign of hip dysplasia or near normal hip joints (nondysplastic group; n = 51) vs mild, moderate, or severe hip dysplasia (dysplastic group; 48). Methods: Serum concentrations and enzyme activity of the biochemical markers hyaluronic acid (HA), procollagen II C-terminal propeptide (PIICP), and metalloproteinase 9 (MMP9) were compared among adult dogs with or without radiographic hip dysplasia. Statistical tests used to examine the differentiating potential of biochemical markers in Tornjak dog groups were assessed using the Mann-Whitney U test, logistic regression, and receiving operating characteristics (ROC) analysis. Results: Tornjak dogs with radiographic CHD had significantly lower serum concentrations of HA and higher concentrations of PIICP and MMP9 activity compared to dogs with radiographically normal hips (P < .05). Selected biochemical markers could distinguish dogs with radiographic CHD from those without CHD with high sensitivity and specificity. Clinical Relevance: These data suggest that the diagnostic technique of measuring serum concentrations of HA, PIICP, and MMP9 activity has a selective ability to distinguish dogs with dysplastic from dogs with normal hips. |
| فهرسة مساهمة: | Keywords: Tornjak; biochemical marker; breed-specific; canine hip dysplasia; osteoarthritis |
| المشرفين على المادة: | EC 3.4.24.35 (Matrix Metalloproteinase 9) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230912 Date Completed: 20231103 Latest Revision: 20231103 |
| رمز التحديث: | 20231103 |
| DOI: | 10.2460/ajvr.23.07.0170 |
| PMID: | 37699541 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!