دورية أكاديمية
Subunit-specific inhibition of BK channels by piperine.
العنوان: | Subunit-specific inhibition of BK channels by piperine. |
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المؤلفون: | Kshatri A; Department of Basic Medical Sciences, Medical School, Universidad de La Laguna, Tenerife, Spain; Instituto de Tecnologias Biomedicas, Universidad de La Laguna, Tenerife, Spain., Rivero-Pérez B; Department of Basic Medical Sciences, Medical School, Universidad de La Laguna, Tenerife, Spain; Instituto de Tecnologias Biomedicas, Universidad de La Laguna, Tenerife, Spain., Giraldez T; Department of Basic Medical Sciences, Medical School, Universidad de La Laguna, Tenerife, Spain; Instituto de Tecnologias Biomedicas, Universidad de La Laguna, Tenerife, Spain. Electronic address: giraldez@ull.edu.es. |
المصدر: | Biophysical journal [Biophys J] 2024 Jul 16; Vol. 123 (14), pp. 1942-1953. Date of Electronic Publication: 2023 Sep 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: New York, Published by Rockefeller University Press [etc.] for the Biophysical Society. |
مواضيع طبية MeSH: | Polyunsaturated Alkamides*/pharmacology , Benzodioxoles*/pharmacology , Piperidines*/pharmacology , Alkaloids*/pharmacology , Large-Conductance Calcium-Activated Potassium Channels*/metabolism , Large-Conductance Calcium-Activated Potassium Channels*/genetics , Protein Subunits*/metabolism, Humans ; HEK293 Cells ; Calcium/metabolism ; Potassium Channel Blockers/pharmacology |
مستخلص: | Piperine is the principal alkaloid present in black pepper and is well-known for its diverse pharmacological effects, including inhibition of different ion channels. Large conductance Ca 2+ -activated K + channels (BK) are widely expressed across several tissues and play a vital role in many physiological functions. In this study, we investigated the pharmacological effects of piperine on various BK channel subunit compositions (BKα, BKαβ Competing Interests: Declaration of interests The authors declare no competing interest. (Copyright © 2023 Biophysical Society. Published by Elsevier Inc. All rights reserved.) |
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المشرفين على المادة: | 0 (Polyunsaturated Alkamides) U71XL721QK (piperine) 0 (Benzodioxoles) 0 (Piperidines) 0 (Alkaloids) 0 (Large-Conductance Calcium-Activated Potassium Channels) 0 (Protein Subunits) SY7Q814VUP (Calcium) 0 (Potassium Channel Blockers) |
تواريخ الأحداث: | Date Created: 20230913 Date Completed: 20240717 Latest Revision: 20240811 |
رمز التحديث: | 20240812 |
مُعرف محوري في PubMed: | PMC11309970 |
DOI: | 10.1016/j.bpj.2023.09.002 |
PMID: | 37700524 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1542-0086 |
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DOI: | 10.1016/j.bpj.2023.09.002 |