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The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study.

التفاصيل البيبلوغرافية
العنوان: The potential immuno-stimulating effect of curcumin, piperine, and taurine combination in hepatocellular carcinoma; a pilot study.
المؤلفون: Kotb RR; Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt., Afifi AM; Department of Zoology, Faculty of Science, Cairo University, Cairo, Egypt., El-Houseini ME; Medical Biochemistry and molecular biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt., Ezz-Elarab M; National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt., Basalious EB; Pharmaceutics and Industrial Pharmacy department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt., Omran MM; Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.; Biological science division, University of Chicago, Chicago, IL, USA., Abdellateif MS; Medical Biochemistry and molecular biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. mona-sayed@cu.edu.eg.
المصدر: Discover. Oncology [Discov Oncol] 2023 Sep 13; Vol. 14 (1), pp. 169. Date of Electronic Publication: 2023 Sep 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Springer, [2021]-
مستخلص: Background: This is a phase II clinical trial to investigate the immunotherapeutic effect of Curcumin, Piperine, and Taurine (CPT) combination in hepatocellular carcinoma (HCC).
Methods: Twenty-six HCC patients aged (50-80 years) were recruited for administration of a daily dose of 5 g of curcumin, 50 mg of piperine, and 500 mg of taurine divided into three doses for successive 3 months. The three components (CPT) were prepared in one capsule. Patients were assessed after each month (cycle) for the plasma levels of CD4, CD8, CD25, Interleukins-2 (IL-2), IL-6, IL-12, Interferon-gamma (IFN- γ), Lactate dehydrogenase (LDH), and Vascular endothelial growth factor (VEGF), FOXP3 mRNA, and miRNA 21.
Results: There was a significant increase in the plasma levels of CD4 and CD8, while a significant decrease in the CD25 level after the second and third cycles compared to the baseline level [P < 0.001 for both]. Also, there was a significant increase in the plasma levels of IL-2, IL-12, and IFN-γ [ P = 0.001, P = 0.006, and P = 0.029; respectively], while there was a significant decrease in IL-6, VEGF-α, LDH, and Alpha-fetoprotein (AFP) after CPT administration compared to the baseline levels [P < 0.001, P < 0.001, P = 0.020, and P = 0.004; respectively]. The expression level of miRNA-21 was significantly decreased after CPT administration compared to the baseline level [5.5±0.88, 4.1±0.78, 3±0.75, and 2.5±0.76; respectively, P<0.001]. Though there was a noticeable decrease in the FOXP3 expression after each cycle, however, it didn't reach a significant level [5.3±0.8, 4.2±0.76, 3.2±0.67, and 2.5±0.79; respectively, P=0.184].
Conclusion: CPT could exhibit a potential immune-stimulating effect in HCC patients. The current trial had been registered at the National Hepatology and Tropical Medicine Research Institute (NHTMRI), with a registration number of NHTMRI-IRB 2-21 on 5th January 2021.
(© 2023. Springer Science+Business Media, LLC.)
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فهرسة مساهمة: Keywords: Curcumin; HCC; Immunomodulation; Liver cancer; Piperine; Taurine
تواريخ الأحداث: Date Created: 20230913 Latest Revision: 20231120
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10499730
DOI: 10.1007/s12672-023-00785-1
PMID: 37704828
قاعدة البيانات: MEDLINE
الوصف
تدمد:2730-6011
DOI:10.1007/s12672-023-00785-1