دورية أكاديمية
Flavonoid compound from Agrimonia pilosa Ledeb improves adipose insulin resistance by alleviating oxidative stress and inflammation.
| العنوان: | Flavonoid compound from Agrimonia pilosa Ledeb improves adipose insulin resistance by alleviating oxidative stress and inflammation. |
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| المؤلفون: | Guo T; Department of Gastroenterology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.; College of Environment and Resources, Chongqing Technology and Business University, Chongqing, China., Pan Y; Department of Gastroenterology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China. panyun0617@163.com., Yang L; College of Environment and Resources, Chongqing Technology and Business University, Chongqing, China., Chen G; College of Environment and Resources, Chongqing Technology and Business University, Chongqing, China., Deng J; College of Environment and Resources, Chongqing Technology and Business University, Chongqing, China., Zhu L; Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China. zhuliancai75@126.com. |
| المصدر: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Sep 14; Vol. 23 (1), pp. 322. Date of Electronic Publication: 2023 Sep 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2020]- |
| مواضيع طبية MeSH: | Insulin Resistance* , Agrimonia* , Diabetes Mellitus, Type 2*/drug therapy, Animals ; Mice ; NF-E2-Related Factor 2 ; PPAR gamma ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Reactive Oxygen Species ; Obesity ; Insulin ; Inflammation/drug therapy ; Cytokines ; Superoxide Dismutase |
| مستخلص: | Background: Researches and practice of traditional Chinese medicine indicated that Agrimonia pilosa Ledeb could improve insulin resistance (IR) and treat type 2 diabetes (T2DM). To reveal its underling mechanisms, we isolated Flavonoid component (FC) from Agrimonia pilosa Ledeb and elucidated its effects on glucose metabolism to improve IR by suppressing oxidative stress and inflammation. Methods: Adipocytes or mice IR model was established with overdosed glucose and insulin or high-fat diet. The uptake of 2-NBDG and glucose consumption were measured to verify insulin sensitivity in vitro and vivo. Reactive oxidative species (ROS) were detected by flow cytometry, and superoxide dismutase (SOD) activity as well as the malondialdehyde (MDA) content were also measured. Meanwhile, factors associated with insulin signal pathway including PPARγ, insulin receptor substrate-1 (IRS-1), GLUT4, and oxidative stress including NF-E2-related factor 2 (Nrf2), as well as the related inflammatory cytokines such as NF-κB, IL-1β, IL-6 and TNF-α were tested. Furthermore, the JNK/PI3K/Akt signal pathway was also explored. Results: FC extracted from Agrimonia pilosa Ledeb ameliorated the impaired glucose metabolism significantly. Further study indicated that FC could regulate the insulin signal pathway to improve insulin resistance. Moreover, it could upregulate PPARγ with the similar efficacy as pioglitazone (Piog) straightway. FC also decreased the endogenous ROS and MDA content, increased SOD activity and Nrf2 expression to facilitate oxidative homeostasis. It attenuated expression and secretion of inflammatory cytokines obviously. At last, our results indicated JNK/PI3K/Akt pathway was regulated by FC in adipocytes and adipose tissue. Conclusion: FC could ameliorate glucose metabolism and improve IR. It exerted these effects by suppressing oxidative stress and inflammation. FC from Agrimonia pilosa Ledeb has a good prospect to be drugs or functional foods for IR and T2DM. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
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| معلومات مُعتمدة: | 11902060 National Natural Science Foundation of China; cstc2020jcyj-msxmX0844 Chongqing Research Program of Basic Research and Frontier Technology; cstc2020jcyj-msxmX0250 Chongqing Research Program of Basic Research and Frontier Technology; cstc2020jcyj-msxmX0711 Chongqing Research Program of Basic Research and Frontier Technology; KJQN201900814 Chongqing Municipal Education Commission; KJQN202000836 Chongqing Municipal Education Commission; KFJJ2022016 Opening Research Platform of Chongqing Technology and Business University |
| فهرسة مساهمة: | Keywords: Adipose; Agrimonia pilosa Ledeb; Flavonoid; Inflammation; Insulin resistance; JNK; Oxidative stress |
| المشرفين على المادة: | 0 (NF-E2-Related Factor 2) 0 (PPAR gamma) EC 2.7.1.- (Phosphatidylinositol 3-Kinases) EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) 0 (Reactive Oxygen Species) 0 (Insulin) 0 (Cytokines) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20230914 Date Completed: 20230918 Latest Revision: 20231123 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10503054 |
| DOI: | 10.1186/s12906-023-04114-5 |
| PMID: | 37710214 |
| قاعدة البيانات: | MEDLINE |
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