Fetal Thymus Size at 19-22 Weeks of Gestation: A Possible Marker for the Prediction of Low Birth Weight?

التفاصيل البيبلوغرافية
العنوان:	Fetal Thymus Size at 19-22 Weeks of Gestation: A Possible Marker for the Prediction of Low Birth Weight?
المؤلفون:	Kim JM; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Oelmeier K; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Braun J; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Hammer K; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Steinhard J; Fetal Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr-University Bochum, Bad Oeynhausen, Germany., Köster HA; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Koch R; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany., Klockenbusch W; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Schmitz R; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany., Möllers M; Department of Gynecology and Obstetrics, University Hospital Münster, Münster, Germany.
المصدر:	Fetal diagnosis and therapy [Fetal Diagn Ther] 2024; Vol. 51 (1), pp. 7-15. Date of Electronic Publication: 2023 Sep 15.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: S. Karger Country of Publication: Switzerland NLM ID: 9107463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9964 (Electronic) Linking ISSN: 10153837 NLM ISO Abbreviation: Fetal Diagn Ther Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Basel ; New York : S. Karger, 1991-
مواضيع طبية MeSH:	Fetal Weight* , Ultrasonography, Prenatal*, Pregnancy ; Infant, Newborn ; Female ; Humans ; Birth Weight ; Pregnancy Trimester, Third ; Prospective Studies ; Infant, Small for Gestational Age ; Fetal Growth Retardation ; Gestational Age ; Predictive Value of Tests
مستخلص:	Introduction: The purpose was to compare thymus size measured during second trimester screening of fetuses who were subsequently small for gestational age at birth (weight below 10th percentile, SGA group) with fetuses with normal birth weight (control group). We hypothesized that measuring the fetal thymic-thoracic ratio (TT-ratio) might help predict low birth weight. Methods: Using three-vessel view echocardiograms from our archives, we measured the anteroposterior thymus size and the intrathoracic mediastinal diameter to derive TT-ratios in the SGA (n = 105) and control groups (n = 533) between 19+0 and 21+6 weeks of gestation. We analyzed the association between TT-ratio and SGA adjusted to the week of gestation using logistic regression. Finally, we determined the possible TT-ratio cut-off point for discrimination between SGA and control groups by means of receiver operating characteristics (ROC) curve analysis. Results: The TT-ratio was significantly higher in the SGA group than in the control group (p < 0.001). An increase of the TT-ratio by 0.1 was associated with a 3.1-fold increase in the odds of diagnosing SGA. We determined that a possible discrimination cut-off point between SGA and healthy controls was achieved using a TT-ratio of 0.390 (area under the ROC curve 0.695). Conclusion: An increased TT-ratio may represent an additional prenatal screening parameter that improves the prediction of birth weight below the 10th percentile. Prospective studies are now needed to evaluate the use of fetal thymus size as predictive parameter for adverse fetal outcome. (© 2023 S. Karger AG, Basel.)
فهرسة مساهمة:	Keywords: Fetal diagnosis; Fetal growth restriction; Prenatal ultrasonography; Small for gestational age; Thymus; Ultrasound
تواريخ الأحداث:	Date Created: 20230917 Date Completed: 20240205 Latest Revision: 20240205
رمز التحديث:	20240205
DOI:	10.1159/000533964
PMID:	37717568
قاعدة البيانات:	MEDLINE

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تدمد:	1421-9964
DOI:	10.1159/000533964