Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4).

التفاصيل البيبلوغرافية
العنوان:	Oxytosis/Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4).
المؤلفون:	Dar NJ; School of Medicine, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. nawabdar@gmail.com., John U; School of Studies in Neuroscience, Jiwaji University, Gwalior, India.; School of Studies in Zoology, Jiwaji University, Gwalior, India., Bano N; Faculty of Life Sciences, Department of Zoology, Aligarh Muslim University, Aligarh, U.P, India., Khan S; Faculty of Life Sciences, Department of Zoology, Aligarh Muslim University, Aligarh, U.P, India., Bhat SA; Faculty of Life Sciences, Department of Zoology, Aligarh Muslim University, Aligarh, U.P, India. sabhat1@myamu.ac.in.
المصدر:	Molecular neurobiology [Mol Neurobiol] 2024 Mar; Vol. 61 (3), pp. 1507-1526. Date of Electronic Publication: 2023 Sep 19.
نوع المنشور:	Journal Article; Review
اللغة:	English
بيانات الدورية:	Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Clifton, NJ : Humana Press, c1987-
مواضيع طبية MeSH:	Ferroptosis* , Neurodegenerative Diseases*, Humans ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Cell Death ; Oxidation-Reduction ; Glutathione Peroxidase/metabolism ; Glutathione/metabolism ; Lipid Peroxidation
مستخلص:	Oxytosis/ferroptosis is an iron-dependent oxidative form of cell death triggered by lethal accumulation of phospholipid hydroperoxides (PLOOHs) in membranes. Failure of the intricate PLOOH repair system is a principle cause of ferroptotic cell death. Glutathione peroxidase 4 (GPX4) is distinctly vital for converting PLOOHs in membranes to non-toxic alcohols. As such, GPX4 is known as the master regulator of oxytosis/ferroptosis. Ferroptosis has been implicated in a number of disorders such as neurodegenerative diseases (amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), etc.), ischemia/reperfusion injury, and kidney degeneration. Reduced function of GPX4 is frequently observed in degenerative disorders. In this study, we examine how diminished GPX4 function may be a critical event in triggering oxytosis/ferroptosis to perpetuate or initiate the neurodegenerative diseases and assess the possible therapeutic importance of oxytosis/ferroptosis in neurodegenerative disorders. These discoveries are important for advancing our understanding of neurodegenerative diseases because oxytosis/ferroptosis may provide a new target to slow the course of the disease. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة:	Keywords: AD; ALS; GPX4; Lipid peroxidation; Neurodegeneration; Oxidative stress; Oxytosis/ferroptosis; PD
المشرفين على المادة:	EC 1.11.1.12 (Phospholipid Hydroperoxide Glutathione Peroxidase) EC 1.11.1.9 (Glutathione Peroxidase) GAN16C9B8O (Glutathione)
تواريخ الأحداث:	Date Created: 20230919 Date Completed: 20240227 Latest Revision: 20240227
رمز التحديث:	20240227
DOI:	10.1007/s12035-023-03646-8
PMID:	37725216
قاعدة البيانات:	MEDLINE

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تدمد:	1559-1182
DOI:	10.1007/s12035-023-03646-8