تقرير
DNA-Based Near-Infrared Voltage Sensors.
| العنوان: | DNA-Based Near-Infrared Voltage Sensors. |
|---|---|
| المؤلفون: | Giammanco G; Department of Bioengineering, George Mason University, Fairfax, Virginia 22030, United States., Veneziano R; Department of Bioengineering, George Mason University, Fairfax, Virginia 22030, United States.; Institute for Advanced Biomedical Research, George Mason University, Manassas, Virginia 20110, United States., Dunn B; Department of Bioengineering, George Mason University, Fairfax, Virginia 22030, United States., Such N; Department of Bioengineering, George Mason University, Fairfax, Virginia 22030, United States., Cressman JR; Department of Physics, George Mason University, Fairfax, Virginia 22030, United States., Chitnis PV; Department of Bioengineering, George Mason University, Fairfax, Virginia 22030, United States.; Center for Adaptive Systems for Brain-body Interactions, George Mason University, Fairfax, Virginia 22030, United States. |
| المصدر: | ACS sensors [ACS Sens] 2023 Oct 27; Vol. 8 (10), pp. 3680-3686. Date of Electronic Publication: 2023 Sep 19. |
| نوع المنشور: | Letter; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101669031 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-3694 (Electronic) Linking ISSN: 23793694 NLM ISO Abbreviation: ACS Sens Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, [2016]- |
| مواضيع طبية MeSH: | Indocyanine Green*/chemistry , Optical Imaging*/methods |
| مستخلص: | Indocyanine green (ICG) is an FDA approved dye widely used for fluorescence imaging in research, surgical navigation, and medical diagnostics. However, ICG has a few drawbacks, such as concentration-dependent aggregation and absorbance, nonspecific cellular targeting, and rapid photobleaching. Here, we report a novel DNA-based nanosensor platform that utilizes monomers of ICG and cholesterol. Using DNA origami, we can attach ICG to a DNA structure, maintaining its concentration, preserving its near-infrared (NIR) absorbance, and allowing attachment of targeting moieties. We characterized the nanosensors' absorbance, stability in blood, and voltage sensing in vitro . This study presents a novel DNA-based ICG nanosensor platform for cellular voltage sensing for future in vivo applications. |
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| فهرسة مساهمة: | Keywords: DNA nanoparticle; DNA nanotechnology; DNA scaffold; indocyanine green (ICG); nanosensor; voltage sensing; whole cell patch clamp |
| المشرفين على المادة: | IX6J1063HV (Indocyanine Green) |
| تواريخ الأحداث: | Date Created: 20230919 Date Completed: 20231030 Latest Revision: 20231102 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10616843 |
| DOI: | 10.1021/acssensors.3c01429 |
| PMID: | 37725687 |
| قاعدة البيانات: | MEDLINE |
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