دورية أكاديمية
أعرض في EDS

Senescence-regulatory factors as novel circulating biomarkers and therapeutic targets in regenerative medicine for osteoarthritis.

التفاصيل البيبلوغرافية
العنوان: Senescence-regulatory factors as novel circulating biomarkers and therapeutic targets in regenerative medicine for osteoarthritis.
المؤلفون: Maroun G; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM UMR 1183, 34298 Montpellier, France., Fissoun C; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM UMR 1183, 34298 Montpellier, France., Villaverde M; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM UMR 1183, 34298 Montpellier, France; HCS Pharma, Biocentre Fleming, 250, rue Salvador-Allende, Bat A, 59120 Loos, France., Brondello JM; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM UMR 1183, 34298 Montpellier, France., Pers YM; Institute for Regenerative Medicine and Biotherapy, University of Montpellier, INSERM UMR 1183, 34298 Montpellier, France; Clinical immunology and osteoarticular diseases Therapeutic Unit, Lapeyronie University Hospital, CHU Montpellier, IRMB, University of Montpellier, INSERM, Montpellier, France. Electronic address: ym-pers@chu-montpellier.fr.
المصدر: Joint bone spine [Joint Bone Spine] 2024 Mar; Vol. 91 (2), pp. 105640. Date of Electronic Publication: 2023 Sep 20.
نوع المنشور: Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Elsevier Country of Publication: France NLM ID: 100938016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1778-7254 (Electronic) Linking ISSN: 1297319X NLM ISO Abbreviation: Joint Bone Spine Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Paris : Editions Elsevier, c2000-
مواضيع طبية MeSH: Osteoarthritis*/diagnosis , Osteoarthritis*/therapy , Osteoarthritis*/genetics , MicroRNAs*, Humans ; Regenerative Medicine ; Synovial Fluid ; Biomarkers
مستخلص: Recent discoveries reveal that the chronic presence of senescent cells in osteoarticular tissues provides a focal point of disease development for osteoarthritis (OA). Nevertheless, senescence-regulatory factors associated with OA still need to be identified. Furthermore, few diagnostic- and prognostic-validated biochemical markers (biomarkers) are currently used in clinics to evaluate OA patients. In the future, alongside imaging and clinical examination, detecting senescence-regulatory biomarkers in patient fluids could become a prospective method for disease: diagnosis, monitoring, progression and prognosis following treatment. This review summarizes a group of circulating OA biomarkers recently linked to senescence onset. Remarkably, these factors identified in proteomics, metabolomic and microRNA studies could also have deleterious or protective roles in osteoarticular tissue homeostasis. In addition, we discuss their potentially innovative modulation in combination with senotherapeutic approaches, for long-lasting OA treatment.
(Copyright © 2023 Société française de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.)
فهرسة مساهمة: Keywords: Biomarkers; Osteoarthritis (OA); Oxidative stress and microRNAs (miRNA); Senescence; Synovial fluid (SF); Systemic plasma factors; Therapeutics
المشرفين على المادة: 0 (MicroRNAs)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20230922 Date Completed: 20240301 Latest Revision: 20240301
رمز التحديث: 20240301
DOI: 10.1016/j.jbspin.2023.105640
PMID: 37739212
قاعدة البيانات: MEDLINE
الوصف
تدمد:1778-7254
DOI:10.1016/j.jbspin.2023.105640