دورية أكاديمية
The Origin and Fate of Liver Myofibroblasts.
| العنوان: | The Origin and Fate of Liver Myofibroblasts. |
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| المؤلفون: | Kim HY; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California., Sakane S; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California., Eguileor A; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California., Carvalho Gontijo Weber R; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California; Department of Surgery, University of California San Diego School of Medicine, La Jolla, California., Lee W; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California., Liu X; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California; Department of Surgery, University of California San Diego School of Medicine, La Jolla, California., Lam K; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California., Ishizuka K; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California., Rosenthal SB; Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, California., Diggle K; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California; Department of Surgery, University of California San Diego School of Medicine, La Jolla, California., Brenner DA; Department of Medicine, University of California San Diego School of Medicine, La Jolla, California; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California. Electronic address: dbrenner@sbpdiscovery.org., Kisseleva T; Department of Surgery, University of California San Diego School of Medicine, La Jolla, California. Electronic address: tkisseleva@health.ucsd.edu. |
| المصدر: | Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2024; Vol. 17 (1), pp. 93-106. Date of Electronic Publication: 2023 Sep 22. |
| نوع المنشور: | Journal Article; Review; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Gastroenterological Association Country of Publication: United States NLM ID: 101648302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-345X (Electronic) Linking ISSN: 2352345X NLM ISO Abbreviation: Cell Mol Gastroenterol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Gastroenterological Association, [2015]- |
| مواضيع طبية MeSH: | Myofibroblasts*/pathology , Liver Cirrhosis*/pathology, Humans ; Fibroblasts/pathology ; Hepatocytes |
| مستخلص: | Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is caused by fibrogenic myofibroblasts that are not present in the normal liver, but rather activate from liver resident mesenchymal cells in response to chronic toxic or cholestatic injury. Many studies indicate that liver fibrosis is reversible when the causative agent is removed. Regression of liver fibrosis is associated with the disappearance of activated myofibroblasts and resorption of the fibrous scar. In this review, we discuss the results of genetic tracing and cell fate mapping of hepatic stellate cells and portal fibroblasts, their specific characteristics, and potential phenotypes. We summarize research progress in the understanding of the molecular mechanisms underlying the development and reversibility of liver fibrosis, including activation, apoptosis, and inactivation of myofibroblasts. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | P42 ES010337 United States ES NIEHS NIH HHS; P30 DK120515 United States DK NIDDK NIH HHS; U01 AA029019 United States AA NIAAA NIH HHS; R01 DK091183 United States DK NIDDK NIH HHS; R01 DK099205 United States DK NIDDK NIH HHS; R01 AA028550 United States AA NIAAA NIH HHS; P50 AA011999 United States AA NIAAA NIH HHS; R01 DK101737 United States DK NIDDK NIH HHS; R44 DK115242 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: Hepatic Stellate Cells; Liver Fibrosis; Portal Fibroblasts |
| تواريخ الأحداث: | Date Created: 20230924 Date Completed: 20231219 Latest Revision: 20240320 |
| رمز التحديث: | 20240321 |
| مُعرف محوري في PubMed: | PMC10665929 |
| DOI: | 10.1016/j.jcmgh.2023.09.008 |
| PMID: | 37743012 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 2352-345X |
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| DOI: | 10.1016/j.jcmgh.2023.09.008 |