دورية أكاديمية
Glycolipids from Sargassum filipendula, a Natural Alternative for Overcoming ABC Transporter-Mediated MDR in Cancer.
| العنوان: | Glycolipids from Sargassum filipendula, a Natural Alternative for Overcoming ABC Transporter-Mediated MDR in Cancer. |
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| المؤلفون: | Muñoz-Losada K; Grupo de Investigación en Compuestos Funcionales, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, 050010, Colombia., Da Costa KM; Laboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-902, Brasil., Muñoz-Castiblanco T; Grupo de Investigación en Compuestos Funcionales, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, 050010, Colombia., Mejía-Giraldo JC; Grupo de Investigación en Compuestos Funcionales, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, 050010, Colombia.; Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, 050010, Colombia., Previato JO; Laboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-902, Brasil., Mendonça-Previato L; Laboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-902, Brasil., Puertas-Mejía MÁ; Grupo de Investigación en Compuestos Funcionales, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, 050010, Colombia. |
| المصدر: | Chemistry & biodiversity [Chem Biodivers] 2023 Nov; Vol. 20 (11), pp. e202301058. Date of Electronic Publication: 2023 Oct 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| مواضيع طبية MeSH: | Filipendula* , Sargassum*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Neoplasms*/metabolism, Humans ; ATP-Binding Cassette Transporters/metabolism ; ATP-Binding Cassette Transporters/pharmacology ; Drug Resistance, Neoplasm ; Drug Resistance, Multiple ; Cell Line, Tumor |
| مستخلص: | Chemotherapy is a widely used strategy to treat cancer, a disease that causes millions of deaths each year. However, its efficacy is reduced by the overexpression of ABC transporters, which are proteins that expel the drugs used in chemotherapy and involved in the multidrug resistance (MDR). Glycolipids have been identified as potential inhibitors of ABC transporters. Algae of the genus Sargassum contain high levels of glycolipids, making them a promising therapeutic alternative against the MDR phenotype. Sargassum filipendula glycolipids were obtained by exhaustive maceration with chloroform/methanol, purified by column and thin layer chromatography, and then characterized by FTIR, NMR, and LC-MS. Cell viability by PI labeling and inhibition of ABC transporters were analyzed by flow cytometry. Assessment of resistance reversal was determined by MTT assay. Ten sulfoquinovosylglycerol-type compounds were found, and six of them are reported for the first time. In particular, moiety 4 (GL-4) showed strong and moderate inhibitory activity against ABCC1 and ABCB1 transporters respectively. Treatment of GL-4 in combination with the antineoplastic drug vincristine sensitized Lucena-1 cell model to drug and reversed the MDR phenotype. This is the first report of glycolipids isolated from S. filipendula capable of inhibiting ABC transporters and thus overcoming acquired drug resistance. (© 2023 Wiley-VHCA AG, Zurich, Switzerland.) |
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| معلومات مُعتمدة: | Universidad de Antioquia; Institute of Chemistry of the University of Antioquia; 2019-25210 CODI of the Universidad de Antioquia; Glycobiology Laboratory/IBCCF/UFRJ; CNPq; FAPERJ; Cancer Foundation/Brazil |
| فهرسة مساهمة: | Keywords: ABCB1; ABCC1; Sargassum filipendula; cancer; glycolipids; multidrug resistance |
| المشرفين على المادة: | 0 (ATP-Binding Cassette Transporters) 60267-39-2 (Forssman glycolipid) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20230925 Date Completed: 20231129 Latest Revision: 20240109 |
| رمز التحديث: | 20240109 |
| DOI: | 10.1002/cbdv.202301058 |
| PMID: | 37747792 |
| قاعدة البيانات: | MEDLINE |
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