دورية أكاديمية
Inflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study.
| العنوان: | Inflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study. |
|---|---|
| المؤلفون: | Choi H; Division of Molecular and Clinical Medicine and.; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea., Ryu S; Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, Republic of Korea., Keir HR; Division of Molecular and Clinical Medicine and., Giam YH; Division of Molecular and Clinical Medicine and., Dicker AJ; Division of Molecular and Clinical Medicine and., Perea L; Division of Molecular and Clinical Medicine and., Richardson H; Division of Molecular and Clinical Medicine and., Huang JTJ; Division of Systems Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom., Cant E; Division of Molecular and Clinical Medicine and., Blasi F; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Pollock J; Division of Molecular and Clinical Medicine and., Shteinberg M; Pulmonology Institute and CF Center, Carmel Medical Center and the Technion-Israel Institute of Technology, Haifa, Israel., Finch S; Division of Molecular and Clinical Medicine and., Aliberti S; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Respiratory Unit, IRCCS Humanitas Research Hospital, Milan, Italy; and., Sibila O; Respiratory Department, Hospital Clínic, IDIBAPS, CIBERES, Universitat de Barcelona, Barcelona, Spain., Shoemark A; Division of Molecular and Clinical Medicine and., Chalmers JD; Division of Molecular and Clinical Medicine and. |
| المصدر: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2023 Dec 01; Vol. 208 (11), pp. 1166-1176. |
| نوع المنشور: | Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : New York, NY : American Thoracic Society Original Publication: New York, NY : American Lung Association, c1994- |
| مواضيع طبية MeSH: | Bronchiectasis*/microbiology, Humans ; Female ; Aged ; Male ; Biomarkers ; Sputum/microbiology ; Inflammation ; Cohort Studies |
| مستخلص: | Rationale: Although inflammation and infection are key disease drivers in bronchiectasis, few studies have integrated host inflammatory and microbiome data to guide precision medicine. Objectives: To identify clusters among patients with bronchiectasis on the basis of inflammatory markers and to assess the association between inflammatory endotypes, microbiome characteristics, and exacerbation risk. Methods: Patients with stable bronchiectasis were enrolled at three European centers, and cluster analysis was used to stratify the patients according to the levels of 33 sputum and serum inflammatory markers. Clusters were compared in terms of microbiome composition (16S ribosomal RNA sequencing) and exacerbation risk over a 12-month follow-up. Measurements and Main Results: A total of 199 patients were enrolled (109 [54.8%] female; median age, 69 yr). Four clusters of patients were defined according to their inflammatory profiles: cluster 1, milder neutrophilic inflammation; cluster 2, mixed-neutrophilic and type 2; cluster 3, most severe neutrophilic; and cluster 4, mixed-epithelial and type 2. Lower microbiome diversity was associated with more severe inflammatory clusters ( P < 0.001), and β-diversity analysis demonstrated distinct microbiome profiles associated with each inflammatory cluster ( P = 0.001). Proteobacteria and Pseudomonas at phylum and genus levels, respectively, were more enriched in clusters 2 and 3 than in clusters 1 and 4. Furthermore, patients in cluster 2 (rate ratio [RR], 1.49; 95% confidence interval [CI], 1.16-1.92) and cluster 3 (RR, 1.61; 95% CI, 1.12-2.32) were at higher risk of exacerbation over a 12-month follow-up compared with cluster 1, even after adjustment for prior exacerbation history. Conclusions: Bronchiectasis inflammatory endotypes are associated with distinct microbiome profiles and future exacerbation risk. |
| التعليقات: | Comment in: Am J Respir Crit Care Med. 2023 Dec 1;208(11):1147-1148. (PMID: 37917354) |
| معلومات مُعتمدة: | European Respiratory Society |
| فهرسة مساهمة: | Keywords: biomarkers; bronchiectasis; cluster analysis; inflammation; microbiome |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230928 Date Completed: 20231204 Latest Revision: 20231214 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1164/rccm.202303-0499OC |
| PMID: | 37769155 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-4970 |
|---|---|
| DOI: | 10.1164/rccm.202303-0499OC |