دورية أكاديمية
Morphological atypia and molecular profile of Plasmodium vivax: Findings from an outbreak in the Brazilian Amazon.
| العنوان: | Morphological atypia and molecular profile of Plasmodium vivax: Findings from an outbreak in the Brazilian Amazon. |
|---|---|
| عنوان ترانسليتريتد: | Atypie morphologique et profil moléculaire de Plasmodium vivax : résultats issus d’une épidémie en Amazonie brésilienne. |
| المؤلفون: | Alves ACJ; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil., Feio Dos Santos AC; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil., Peres JMV; Laboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil., Nascimento JMS; Laboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil., Barbosa DRL; Laboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil., Figueiredo JV; Multiprofessional Residency Program in Animal Reproduction, Federal Rural University of the Amazon, Avenida Presidente Tancredo Neves, 2501, Belém, Pará, Brazil., Viana GMR; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Basic Research in Malaria, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil., Póvoa MM; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Rua Augusto Corrêa, 01, Belém, Pará, Brazil - Laboratory of Malaria Entomology, Parasitology Section, Evandro Chagas Institute, Rodovia BR 316, Km 7, Ananindeua, Pará, Brazil. |
| المصدر: | Parasite (Paris, France) [Parasite] 2023; Vol. 30, pp. 38. Date of Electronic Publication: 2023 Sep 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Princeps Editions Country of Publication: France NLM ID: 9437094 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1776-1042 (Electronic) Linking ISSN: 1252607X NLM ISO Abbreviation: Parasite Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1995-: Issy-les-Moulineaux : Princeps Editions Original Publication: Paris : PDG Communication, [1994- |
| مواضيع طبية MeSH: | Malaria, Vivax*/epidemiology , Malaria*, Humans ; Plasmodium vivax ; Brazil/epidemiology ; Protozoan Proteins/genetics |
| مستخلص: | This study aimed to perform morphological and molecular analyses of parasites isolated from the blood of malaria-infected individuals during an outbreak in the Microregion of Cametá, State of Pará, Brazilian Amazon. A total of 260 positive samples were identified by microscopy as Plasmodium vivax; however, in three samples, forms considered unusual for the species were found and defined as morphological atypia of P. vivax. Single P. vivax infection was confirmed by qPCR in all samples. Among 256 genotyped samples, the VK247 genotype alone was identified in 255 samples, and the VK210 genotype was found in only one. The study showed that this malaria outbreak was caused by the etiological agent P. vivax, and for the first time, morphological atypia was described in isolates circulating in Brazil. Likewise, for the first time, the VK247 genotype was detected predominantly in single infections in an area of the State of Pará, which may suggest a greater circulation of the genotype in the region. (© ACJ Alves et al., published by EDP Sciences, 2023.) |
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| معلومات مُعتمدة: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 302292/2017-2019 Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| فهرسة مساهمة: | Keywords: Genotyping; Morphological atypia; Outbreak; Plasmodium vivax Local Abstract: [Publisher, French] Atypie morphologique et profil moléculaire de Plasmodium vivax : résultats issus d’une épidémie en Amazonie brésilienne. [Publisher, French] Cette étude visait à effectuer des analyses morphologiques et moléculaires de parasites isolés du sang d’individus infectés par le paludisme lors d’une épidémie dans la microrégion de Cametá, État du Pará, Amazonie brésilienne. Au total, 260 échantillons positifs ont été identifiés par microscopie comme Plasmodium vivax mais dans trois échantillons, des formes considérées comme inhabituelles pour l’espèce ont été trouvées et définies comme des atypies morphologiques de P. vivax. Une infection simple à P. vivax a été confirmée par qPCR dans tous les échantillons. Sur 256 échantillons génotypés, le génotype VK247 seul a été identifié dans 255 échantillons, et le génotype VK210 a été trouvé dans un seul échantillon. L’étude a montré que cette épidémie de paludisme était causée par l’agent étiologique P. vivax et, pour la première fois, une atypie morphologique a été décrite dans des isolats circulant au Brésil. De même, pour la première fois, le génotype VK247 a été détecté principalement dans des infections uniques dans une zone de l’État de Pará, ce qui peut suggérer une plus grande circulation du génotype dans la région. |
| المشرفين على المادة: | 0 (Protozoan Proteins) |
| تواريخ الأحداث: | Date Created: 20230929 Date Completed: 20231002 Latest Revision: 20231004 |
| رمز التحديث: | 20231004 |
| مُعرف محوري في PubMed: | PMC10540677 |
| DOI: | 10.1051/parasite/2023039 |
| PMID: | 37772844 |
| قاعدة البيانات: | MEDLINE |
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