دورية أكاديمية
Antiphospholipid antibody carriers and patients with quiescent antiphospholipid syndrome show persistent subclinical complement activation.
| العنوان: | Antiphospholipid antibody carriers and patients with quiescent antiphospholipid syndrome show persistent subclinical complement activation. |
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| المؤلفون: | Zen M; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Tonello M; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Favaro M; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Del Ross T; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Calligaro A; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Giollo A; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Vesentini F; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Gennaio IA; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Arru F; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Ruffatti A; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy., Doria A; Department of Medicine, Rheumatology Unit, University of Padua, Padova, Italy. |
| المصدر: | Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 May 03; Vol. 63 (6), pp. 1733-1738. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Avenel, N.J. : Oxford University Press ; Distributed by Mercury International, c1999- |
| مواضيع طبية MeSH: | Antiphospholipid Syndrome*/immunology , Antibodies, Antiphospholipid*/blood , Antibodies, Antiphospholipid*/immunology , Complement Activation*/immunology, Humans ; Female ; Adult ; Male ; Middle Aged ; Pregnancy ; Thrombosis/immunology ; Thrombosis/etiology ; Case-Control Studies ; Complement Membrane Attack Complex/metabolism ; Complement Membrane Attack Complex/immunology ; Complement C5a/immunology |
| مستخلص: | Objectives: Complement activation has been advocated as one mechanism by which aPLs can induce thrombosis. In patients with catastrophic APS or re-thrombosis, enhanced complement activation has been shown, even in the quiescent phase of the disease. We aimed to assess complement activation and to investigate its association with clinical variables in aPL-positive patients with a favourable disease course. Methods: Subjects with at least two consecutive positive aPL results obtained ≥12 weeks apart were enrolled. They were subjects without a history of thrombosis or pregnancy morbidity (aPL carriers), patients with pregnancy morbidity alone, i.e. obstetric APS patients (OAPS patients), and/or patients with arterial, venous, or small-vessel thrombotic APS (TAPS patients); for enrolment, all patients were required to have been free of symptoms for ≥2 years. Patients affected with systemic autoimmune diseases were excluded. Healthy age- and sex-matched subjects were included as controls. Plasma C5a and C5b-9 levels were assessed by commercially available ELISA assays. The non-parametric Mann-Whitney test and Spearman's correlation were applied. Results: Thirty-seven OAPS patients, 38 TAPS patients, 42 aPL carriers and 30 healthy subjects were enrolled. The median C5a and C5b-9 levels were significantly higher in quiescent aPL-positive patients (OAPS, TAPS, aPL carriers) compared with controls: C5a ng/ml 10.61 [interquartile range (IQR) 6.87-15.46] vs 4.06 (2.66-7.35), P < 0.001; C5b-9 ng/ml 283.95 (175.8-439.40) vs 165.90 (124.23-236.8), P < 0.001. Similar C5a and C5b-9 levels were observed in OAPS and TAPS patients and aPL carriers. A positive correlation between the median C5b-9 levels and the number of aPL-positive tests was found (P = 0.002). Conclusion: The persistence of aPL antibodies is associated with a persistent subclinical activation of the complement cascade. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: C5a; C5b-9; aPL carriers; antiphospholipid antibodies; complement activation; thrombosis |
| المشرفين على المادة: | 0 (Antibodies, Antiphospholipid) 0 (Complement Membrane Attack Complex) 80295-54-1 (Complement C5a) |
| تواريخ الأحداث: | Date Created: 20230929 Date Completed: 20240603 Latest Revision: 20240604 |
| رمز التحديث: | 20240604 |
| DOI: | 10.1093/rheumatology/kead517 |
| PMID: | 37774001 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1462-0332 |
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| DOI: | 10.1093/rheumatology/kead517 |