دورية أكاديمية
Genomic epidemiological investigation of an outbreak of Serratia marcescens neurosurgical site infections associated with contaminated haircutting toolkits in a hospital barber shop.
| العنوان: | Genomic epidemiological investigation of an outbreak of Serratia marcescens neurosurgical site infections associated with contaminated haircutting toolkits in a hospital barber shop. |
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| المؤلفون: | Liu X; Chinese PLA Centre for Disease Control and Prevention, Beijing, China., Yan Z; Department of Disease Prevention and Control, The Second Medical Centre of Chinese PLA General Hospital, Beijing, China., Ye L; Department of Laboratory Medicine, The First Medical Centre of Chinese PLA General Hospital, Beijing, China., Wang K; Chinese PLA Centre for Disease Control and Prevention, Beijing, China., Li J; Chinese PLA Centre for Disease Control and Prevention, Beijing, China., Lin Y; Chinese PLA Centre for Disease Control and Prevention, Beijing, China., Liao C; Chinese PLA Centre for Disease Control and Prevention, Beijing, China; School of Public Health, China Medical University, Shenyang, China., Liu Y; Department of Disease Prevention and Control, The First Medical Centre of Chinese PLA General Hospital, Beijing, China., Li P; Chinese PLA Centre for Disease Control and Prevention, Beijing, China. Electronic address: jiekenlee@126.com., Du M; Department of Disease Prevention and Control, The First Medical Centre of Chinese PLA General Hospital, Beijing, China. Electronic address: dumingm@163.com. |
| المصدر: | The Journal of hospital infection [J Hosp Infect] 2023 Dec; Vol. 142, pp. 58-66. Date of Electronic Publication: 2023 Sep 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders For The Hospital Infection Society Country of Publication: England NLM ID: 8007166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2939 (Electronic) Linking ISSN: 01956701 NLM ISO Abbreviation: J Hosp Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : W.B. Saunders For The Hospital Infection Society Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Cross Infection*/epidemiology , Cross Infection*/diagnosis , Serratia Infections*/epidemiology, Humans ; Disease Outbreaks ; Genomics ; Hospitals ; Serratia marcescens/genetics |
| مستخلص: | Background: Nine surgical site infections caused by Serratia marcescens were diagnosed in neurosurgical patients in a 3500-bed hospital between 2 nd February and 6 th April 2022. Objective: To trace the source of infections caused by S. marcescens to expedite termination of the outbreak and prevent future epidemics. Methods: A review of all surgical procedures and cultures yielding S. marcescens since February 2022 was conducted. Samples were collected from patients and environmental sources. S. marcescens isolates were characterized by antibiotic susceptibility testing. Whole-genome sequencing (WGS) was used to investigate genetic relationships. Resistance genes, virulence genes and plasmid replicons were identified. Results: S. marcescens was isolated from patients' puncture fluid, cerebrospinal fluid and other secretions, and was also cultured from the barbers' haircutting tools, including leather knives, slicker scrapers and razors. In total, 15 isolates were obtained from patients and eight isolates were obtained from haircutting tools. All isolates exhibited identical antibiotic resistance patterns. WGS revealed close clustering among the 23 isolates which differed significantly from previous strains. Three resistance genes and nine virulence-associated genes were detected in all isolates, and 19 of 23 isolates harboured an MOBP-type plasmid. The results confirmed an outbreak of S. marcescens, which was traced to contaminated haircutting tools in the hospital barber shop. The outbreak ended after extensive reinforcement of infection control procedures and re-education of the barbers. Conclusions: These results highlight the risk of postoperative infections related to pre-operative skin preparation, and demonstrate the value of next-generation sequencing tools to expedite outbreak investigations. (Copyright © 2023 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Neurosurgical postoperative wound infections; Serratia marcescens; Whole-genome sequencing |
| تواريخ الأحداث: | Date Created: 20230929 Date Completed: 20231127 Latest Revision: 20231127 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.jhin.2023.09.013 |
| PMID: | 37774927 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-2939 |
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| DOI: | 10.1016/j.jhin.2023.09.013 |