دورية أكاديمية
Trimethoprim/Sulfamethoxazole vs Minocycline for the Treatment of Nonurinary Monomicrobial Stenotrophomonas maltophilia Infections in Hospitalized Patients.
| العنوان: | Trimethoprim/Sulfamethoxazole vs Minocycline for the Treatment of Nonurinary Monomicrobial Stenotrophomonas maltophilia Infections in Hospitalized Patients. |
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| المؤلفون: | Hevia EC; Department of Pharmacy, AdventHealth Orlando, Orlando, FL, USA., Wooten L; Department of Pharmacy, AdventHealth Orlando, Orlando, FL, USA., Carr AL; Department of Pharmacy, AdventHealth Orlando, Orlando, FL, USA. |
| المصدر: | The Annals of pharmacotherapy [Ann Pharmacother] 2024 Jul; Vol. 58 (7), pp. 698-704. Date of Electronic Publication: 2023 Sep 30. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 9203131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-6270 (Electronic) Linking ISSN: 10600280 NLM ISO Abbreviation: Ann Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sept. 2013- : Thousand Oaks, CA : Sage Original Publication: Cincinnati, OH : Harvey Whitney Books Co., c1992- |
| مواضيع طبية MeSH: | Stenotrophomonas maltophilia*/drug effects , Stenotrophomonas maltophilia*/isolation & purification , Trimethoprim, Sulfamethoxazole Drug Combination*/therapeutic use , Gram-Negative Bacterial Infections*/drug therapy , Gram-Negative Bacterial Infections*/microbiology , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/administration & dosage , Minocycline*/therapeutic use , Minocycline*/administration & dosage, Humans ; Male ; Retrospective Studies ; Female ; Middle Aged ; Aged ; Hospitalization/statistics & numerical data ; Adult ; Treatment Outcome ; Aged, 80 and over |
| مستخلص: | Background: Stenotrophomonas maltophilia is an opportunistic, gram-negative bacillus with few therapeutic options due to a high level of intrinsic resistance. Trimethoprim/sulfamethoxazole (SXT) is recommended as the first-line treatment; however, minocycline (MIN) has been shown to have similar clinical outcomes in treating S. maltophilia and addresses concern for increasing resistance to SXT. Objective: The objective of this study is to evaluate the efficacy and safety outcomes of nonurinary, monomicrobial infections due to S. maltophilia in hospitalized patients treated with MIN or SXT. Methods: This was a retrospective study of hospitalized adult patients receiving MIN or SXT for nonurinary monomicrobial S. maltophilia infection from April 1, 2018 to March 31, 2020. The primary outcome was clinical disposition classified as rates of clinical failure, clinical improvement, or clinical success. Results: Eighty-two patients (88.2%) received MIN and 11 patients (11.8%) received SXT initially. Clinical failure occurred in 16 (19.5%) patients in the MIN group and in 4 (36.4%) patients in the SXT group ( P = 0.242). Clinical improvement occurred in 11 (13.4%) patients in the MIN group and in 1 (9.1%) patient in the SXT group ( P = 1.0). Clinical success occurred in 55 (67.1%) patients in the MIN group and in 6 (54.5%) patients in the SXT group ( P = 0.503). Total duration of antimicrobial therapy ( P = 0.3198), in-hospital mortality ( P = 1.0), hospital length of stay ( P = 0.9668), intensive care unit (ICU) length of stay ( P = 0.1384), and 30-day readmission ( P = 0.686) were similar between groups. Conclusions and Relevance: Rates of clinical failure, clinical improvement, or clinical success were similar between MIN and SXT for nonurinary monomicrobial S. maltophilia infections. Competing Interests: Declaration of Conflicting InterestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: A.L.C. has served on advisory boards for Melinta, Ferring, LaJolla, Entasis, and MicroGenDX. A.L.C. serves as the site principal investigator for a retrospective chart studies sponsored by Shionogi and Karius. She does not receive salary support or funding for involvement with these studies. |
| فهرسة مساهمة: | Keywords: Stenotrophomonas maltophilia; minocycline; trimethoprim/sulfamethoxazole |
| المشرفين على المادة: | 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination) 0 (Anti-Bacterial Agents) FYY3R43WGO (Minocycline) |
| تواريخ الأحداث: | Date Created: 20230930 Date Completed: 20240603 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| DOI: | 10.1177/10600280231201850 |
| PMID: | 37776160 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1542-6270 |
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| DOI: | 10.1177/10600280231201850 |