دورية أكاديمية
Lithium isotopes differentially modify mitochondrial amorphous calcium phosphate cluster size distribution and calcium capacity.
| العنوان: | Lithium isotopes differentially modify mitochondrial amorphous calcium phosphate cluster size distribution and calcium capacity. |
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| المؤلفون: | Deline ML; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Straub J; Department of Physics, University of California, Santa Barbara, CA, United States., Patel M; Department of Physics, University of California, Santa Barbara, CA, United States., Subba P; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Grashei M; Department of Nuclear Medicine, TUM School of Medicine, Technical University of Munich, Munich, Germany., van Heijster FHA; Department of Nuclear Medicine, TUM School of Medicine, Technical University of Munich, Munich, Germany., Pirkwieser P; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising, Germany., Somoza V; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising, Germany.; Chair of Nutritional Systems Biology, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Livingstone JD; School of Pharmacy, University of Waterloo, Waterloo, ON, Canada., Beazely M; School of Pharmacy, University of Waterloo, Waterloo, ON, Canada., Kendall B; Department of Earth and Environmental Sciences, University of Waterloo, Waterloo, ON, Canada., Gingras MJP; Department of Physics and Astronomy, University of Waterloo, Waterloo, ON, Canada.; CIFAR, MaRS Centre, Toronto, ON, Canada., Leonenko Z; Department of Physics and Astronomy, University of Waterloo, Waterloo, ON, Canada.; Department of Biology, University of Waterloo, Waterloo, ON, Canada., Höschen C; Chair of Soil Science, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Harrington G; Chair of Soil Science, TUM School of Life Sciences, Technical University of Munich, Munich, Germany., Kuellmer K; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Bian W; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Schilling F; Department of Nuclear Medicine, TUM School of Medicine, Technical University of Munich, Munich, Germany., Fisher MPA; Department of Physics, University of California, Santa Barbara, CA, United States., Helgeson ME; Department of Chemical Engineering, University of California, Santa Barbara, CA, United States., Fromme T; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.; EKFZ-Else Kröner-Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany. |
| المصدر: | Frontiers in physiology [Front Physiol] 2023 Sep 15; Vol. 14, pp. 1200119. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
| مستخلص: | Lithium is commonly prescribed as a mood stabilizer in a variety of mental health conditions, yet its molecular mode of action is incompletely understood. Many cellular events associated with lithium appear tied to mitochondrial function. Further, recent evidence suggests that lithium bioactivities are isotope specific. Here we focus on lithium effects related to mitochondrial calcium handling. Lithium protected against calcium-induced permeability transition and decreased the calcium capacity of liver mitochondria at a clinically relevant concentration. In contrast, brain mitochondrial calcium capacity was increased by lithium. Surprisingly, 7 Li acted more potently than 6 Li on calcium capacity, yet 6 Li was more effective at delaying permeability transition. The size distribution of amorphous calcium phosphate colloids formed in vitro was differentially affected by lithium isotopes, providing a mechanistic basis for the observed isotope specific effects on mitochondrial calcium handling. This work highlights a need to better understand how mitochondrial calcium stores are structurally regulated and provides key considerations for future formulations of lithium-based therapeutics. Competing Interests: MF holds a US patent (US 9,044,418 B2) issued on 2 June 2015 for clinical uses of isotope-modified lithium formulations entitled, “Treatment for depression and other mental conditions with synthetic isotope-modified lithium”. This study was in part funded by a research grant by IONIS Pharmaceuticals, United States, to MF, TF, MiG, ZL, and MH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Deline, Straub, Patel, Subba, Grashei, van Heijster, Pirkwieser, Somoza, Livingstone, Beazely, Kendall, Gingras, Leonenko, Höschen, Harrington, Kuellmer, Bian, Schilling, Fisher, Helgeson and Fromme.) |
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| فهرسة مساهمة: | Keywords: amorphous calcium phosphate; calcium; isotope distribution; lithium; lithium bioactivity; mitochondria; mitochondrial calcium |
| تواريخ الأحداث: | Date Created: 20231002 Latest Revision: 20231004 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10540846 |
| DOI: | 10.3389/fphys.2023.1200119 |
| PMID: | 37781224 |
| قاعدة البيانات: | MEDLINE |
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