دورية أكاديمية
Zingiber officinale rhizome extracts mediated ni nanoparticles and its promising biomedical and environmental applications.
| العنوان: | Zingiber officinale rhizome extracts mediated ni nanoparticles and its promising biomedical and environmental applications. |
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| المؤلفون: | Abdullah; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, Gliwice, 44-100, Poland. abdullah.abdullah@polsl.pl.; Joint Doctoral School, Silesian University of Technology, Academika 2a, Gliwice, 44-100, Poland. abdullah.abdullah@polsl.pl.; Department of Microbiology, Abdul Wali Khan University Mardan, Mardan, 23200, Khyber Pakhtunkhwa, Pakistan. abdullah.abdullah@polsl.pl., Hussain T; Department of Microbiology, Abdul Wali Khan University Mardan, Mardan, 23200, Khyber Pakhtunkhwa, Pakistan., Faisal S; Institube of Biotechnology and Microbiology, Bacha Khan University, Charsadda, Khyber Pakhtunkhwa, 24460, Pakistan., Rizwan M; Center for Biotechnology and Microbiology, University of Swat, Swat, Khyber Pakhtunkhwa, 19000, Pakistan., Almostafa MM; Department of Chemistry, College of Science, King Faisal University, Alhofuf, 31982, Al-Ahsa, Saudi Arabia., Younis NS; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Alhofuf, Al-Ahsa, 31982, Saudi Arabia., Yahya G; Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Al Sharqia, 44519, Egypt. |
| المصدر: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Oct 03; Vol. 23 (1), pp. 349. Date of Electronic Publication: 2023 Oct 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2020]- |
| مواضيع طبية MeSH: | Zingiber officinale* , Metal Nanoparticles*/chemistry , Metal Nanoparticles*/toxicity, Nickel ; Rhizome ; Hypoglycemic Agents/pharmacology ; alpha-Amylases |
| مستخلص: | Background: Zingiber officinale, generally known as ginger, contains bioactive phytochemicals, including gingerols and shogaols, that may function as reducing agents and stabilizers for the formation of nickel nanoparticles (Ni-NPs). Ginger extract-mediated nickel nanoparticles were synthesized using an eco-friendly method, and their antibacterial, antioxidant, antiparasitic, antidiabetic, anticancer, dye degrading, and biocompatibility properties were investigated. Methods: UV-visible spectroscopy, fourier transform infrared spectroscopy, X-ray powder diffraction, energy-dispersive X-ray spectroscopy, and scanning electron microscopy were used to validate and characterize the synthesis of Ni-NPs. Agar well diffusion assay, alpha-amylase and glucosidase inhibitory assay, free radical scavenging assay, biocompatibility assay, and MTT assay were used to analyse the biomedical importance of Ni-NPs. Results: SEM micrograph examinations revealed almost aggregates of Ni-NPs; certain particles were monodispersed and spherical, with an average grain size of 74.85 ± 2.5 nm. Ni-NPs have successfully inhibited the growth of Pseudomonas aeruginosa, Escherichia coli, and Proteus vulgaris by inducing membrane damage, as shown by the absorbance at 260 nm (A260). DPPH (2,2-diphenyl-1-picrylhydrazyl) free radicals were successfully scavenged by Ni-NPs at an inhibition rate of 69.35 ± 0.81% at 800 µg/mL. A dose-dependent cytotoxicity of Ni-NPs was observed against amastigote and promastigote forms of Leishmania tropica, with significant mortality rates of 94.23 ± 1.10 and 92.27 ± 1.20% at 1.0 mg/mL, respectively. Biocompatibility studies revealed the biosafe nature of Ni-NPs by showing RBC hemolysis up to 1.53 ± 0.81% at 400 µg/mL, which is considered safe according to the American Society for Materials and Testing (ASTM). Furthermore, Ni-NPs showed antidiabetic activity by inhibiting α-amylase and α-glucosidase enzymes at an inhibition rate of 22.70 ± 0.16% and 31.23 ± 0.64% at 200 µg/mL, respectively. Ni-NPs have shown significant cytotoxic activity by inhibiting MCF-7 cancerous cells up to 68.82 ± 1.82% at a concentration of 400 µg/mL. The IC50 for Ni-NPs was almost 190 µg/mL. Ni-NPs also degraded crystal violet dye up to 86.1% at 2 h of exposure. Conclusions: In conclusion, Zingiber officinale extract was found successful in producing stable nanoparticles. Ni-NPs have shown substantial biomedical activities, and as a result, we believe these nanoparticles have potential as a powerful therapeutic agent for use in nanomedicine. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
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| معلومات مُعتمدة: | Grant No. 2566 Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia |
| فهرسة مساهمة: | Keywords: Antimicrobial; Antioxidant; Biocompatible; Ginger; Nanoparticles; Nickel |
| المشرفين على المادة: | C5529G5JPQ (ginger extract) 7OV03QG267 (Nickel) 0 (Hypoglycemic Agents) EC 3.2.1.1 (alpha-Amylases) |
| تواريخ الأحداث: | Date Created: 20231003 Date Completed: 20231101 Latest Revision: 20240109 |
| رمز التحديث: | 20240109 |
| مُعرف محوري في PubMed: | PMC10546789 |
| DOI: | 10.1186/s12906-023-04182-7 |
| PMID: | 37789322 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2662-7671 |
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| DOI: | 10.1186/s12906-023-04182-7 |