دورية أكاديمية
أعرض في EDS

Establishment of persistent enteric mycobacterial infection following streptomycin pre-treatment.

التفاصيل البيبلوغرافية
العنوان: Establishment of persistent enteric mycobacterial infection following streptomycin pre-treatment.
المؤلفون: Duffy SC; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.; McGill International TB Centre, Montreal, QC, Canada.; The Infectious Diseases and Immunity in Global Health Program, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Lupien A; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.; McGill International TB Centre, Montreal, QC, Canada.; The Infectious Diseases and Immunity in Global Health Program, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.; Department of Medicine, McGill University, Montreal, QC, Canada., Elhaji Y; Diagnostic Genomic Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar., Farag M; Department of Pathology, McGill University, Montreal, QC, Canada.; Department of Laboratory Medicine, Division of Pathology, McGill University Health Center, Montreal, QC, Canada., Marcus V; Department of Pathology, McGill University, Montreal, QC, Canada.; Department of Laboratory Medicine, Division of Pathology, McGill University Health Center, Montreal, QC, Canada., Behr MA; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada. marcel.behr@mcgill.ca.; McGill International TB Centre, Montreal, QC, Canada. marcel.behr@mcgill.ca.; The Infectious Diseases and Immunity in Global Health Program, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada. marcel.behr@mcgill.ca.; Department of Medicine, McGill University, Montreal, QC, Canada. marcel.behr@mcgill.ca.
المصدر: Gut pathogens [Gut Pathog] 2023 Oct 03; Vol. 15 (1), pp. 46. Date of Electronic Publication: 2023 Oct 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101474263 Publication Model: Electronic Cited Medium: Print ISSN: 1757-4749 (Print) Linking ISSN: 17574749 NLM ISO Abbreviation: Gut Pathog Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مستخلص: Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis, a chronic gastrointestinal disease affecting ruminants. This disease remains widespread in part due to the limitations of available diagnostics and vaccines. A representative small animal model of disease could act as a valuable tool for studying its pathogenesis and to develop new methods for paratuberculosis control, but current models are lacking. Streptomycin pre-treatment can reduce colonization resistance and has previously been shown to improve enteric infection in a Salmonella model. Here, we investigated whether streptomycin pre-treatment of mice followed by MAP gavage could act as a model of paratuberculosis which mimics the natural route of infection and disease development in ruminants. The infection outcomes of MAP were compared to M. avium subsp. hominissuis (MAH), an environmental mycobacterium, and M. bovis and M. orygis, two tuberculous mycobacteria. Streptomycin pre-treatment was shown to consistently improve bacterial infection post-oral inoculation. This model led to chronic MAP infection of the intestines and mesenteric lymph nodes (MLNs) up to 24-weeks post-gavage, however there was no evidence of inflammation or disease. These infection outcomes were found to be specific to MAP. When the model was applied to a bacterium of lesser virulence MAH, the infection was comparatively transient. Mice infected with bacteria of greater virulence, M. bovis or M. orygis, developed chronic intestinal and MLN infection with pulmonary disease similar to zoonotic TB. Our findings suggest that a streptomycin pre-treatment mouse model could be applied to future studies to improve enteric infection with MAP and to investigate other modifications underlying MAP enteritis.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
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معلومات مُعتمدة: Doctoral Training Award Fonds de Recherche du Québec - Santé; FDN-148362 The Canadian Institutes for Health Research
فهرسة مساهمة: Keywords: Crohn’s disease; Mouse models; Mycobacterium avium subsp. hominissuis; Mycobacterium avium subsp. paratuberculosis; Mycobacterium bovis; Mycobacterium orygis; Paratuberculosis
تواريخ الأحداث: Date Created: 20231003 Latest Revision: 20231121
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10546655
DOI: 10.1186/s13099-023-00573-w
PMID: 37789445
قاعدة البيانات: MEDLINE
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