دورية أكاديمية
أعرض في EDS

Lactulose vs Polyethylene Glycol for Bowel Preparation: A Single-Center, Prospective, Randomized Controlled Study Based on BMI.

التفاصيل البيبلوغرافية
العنوان: Lactulose vs Polyethylene Glycol for Bowel Preparation: A Single-Center, Prospective, Randomized Controlled Study Based on BMI.
المؤلفون: Wenqi S; Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing City, P.R. China., Bei Z, Yunrong W, Xinrong W, Yifan L, Weiwei W, Muhan N, Peng Y, Xiaotan D, Wen L, Hua Y, Lei W, Min C
المصدر: Clinical and translational gastroenterology [Clin Transl Gastroenterol] 2024 Jan 01; Vol. 15 (1), pp. e00652. Date of Electronic Publication: 2024 Jan 01.
نوع المنشور: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101532142 Publication Model: Electronic Cited Medium: Internet ISSN: 2155-384X (Electronic) Linking ISSN: 2155384X NLM ISO Abbreviation: Clin Transl Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2019-> : [Philadelphia, PA] : Wolters Kluwer Health
Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Polyethylene Glycols*/adverse effects , Adenoma*, Humans ; Lactulose/adverse effects ; Cathartics/adverse effects ; Body Mass Index ; Prospective Studies ; Colonoscopy/methods
مستخلص: Introduction: Colonoscopy is currently considered as one of the principal techniques to diagnose the colorectal diseases. Admittedly, qualified bowel preparation before colonoscopy is a premise for high-quality examination. Lower quality bowel preparation might seriously impede visualization of the intestinal mucosa, resulting in missed and misdiagnosed intestinal lesions. Therefore, it is necessary to choose the appropriate oral laxative based on the guarantee of safety and efficacy.
Methods: This prospective randomized controlled study was conducted to compare lactulose oral solution and polyethylene glycol (PEG) electrolyte powder for bowel preparation using the following indicators: Boston Bowel Preparation Scale, Bowel Bubble Score, detection rate of adenoma and lesion, patients' satisfaction, and adverse effects. Our study investigated the suitability of 2 bowel preparation reagents for patients with different body mass indices mainly based on body mass index (BMI).
Results: In the lactulose group, there was a significant improvement in the quality of bowel preparation compared with those in the PEG group ( P < 0.05), especially in people with normal BMI and higher BMI. Compared with the PEG group, individuals in the lactulose group had a significantly higher adenoma detection rate (50% vs 33.5%, P < 0.05) and taste scores (8.82 vs 6.69, P < 0.05), as well as significantly fewer adverse reactions (6.5% vs 32.5%, P < 0.05).
Discussion: Lactulose oral solution is superior to PEG in bowel preparation quality and taste, especially in normal BMI and higher BMI groups. It can be used clinically as a potential and promising bowel preparation agent in the future. Clinical Trial registration number: ChiCTR2100054318.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)
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المشرفين على المادة: 3WJQ0SDW1A (Polyethylene Glycols)
4618-18-2 (Lactulose)
0 (Cathartics)
تواريخ الأحداث: Date Created: 20231005 Date Completed: 20240129 Latest Revision: 20240417
رمز التحديث: 20240417
مُعرف محوري في PubMed: PMC10810567
DOI: 10.14309/ctg.0000000000000652
PMID: 37795904
قاعدة البيانات: MEDLINE
الوصف
تدمد:2155-384X
DOI:10.14309/ctg.0000000000000652