دورية أكاديمية
أعرض في EDS

Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study.

التفاصيل البيبلوغرافية
العنوان: Comparative assessment of erythrocyte sphingolipid levels as potential cardiovascular health markers in women from Libya and Serbia: a small-scale study.
المؤلفون: Vidović N; Institute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, Serbia., Knez M; Institute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, Serbia., Ranić M; Institute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, Serbia., Faid F; Institute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, Serbia.; Faculty of Nursing, Misurata University, Misrata, Libya., Jović D; Center for Hygiene and Human Ecology, Institute of Public Health of Serbia 'Dr Milan Jovanović Batut', Belgrade, Serbia., Glibetic M; Institute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, Serbia., Takić M; Institute for Medical Research, National Institute of Republic of Serbia, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Belgrade, Serbia.
المصدر: The Libyan journal of medicine [Libyan J Med] 2023 Dec; Vol. 18 (1), pp. 2264568. Date of Electronic Publication: 2023 Oct 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101299403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1819-6357 (Electronic) Linking ISSN: 18196357 NLM ISO Abbreviation: Libyan J Med Subsets: MEDLINE
أسماء مطبوعة: Publication: <2016- > : Philadelphia, PA : Taylor & Francis
Original Publication: [Libya] : Ibnosina Medical Association
مواضيع طبية MeSH: Sphingolipids* , Cardiovascular Diseases*, Humans ; Female ; Libya/epidemiology ; Serbia/epidemiology ; Erythrocytes ; Biomarkers ; Cholesterol
مستخلص: Aim : Cardiovascular diseases (CVDs) represent the major cause of morbidity and mortality worldwide including Libya, where they account for 43% of all deaths. Sphingolipids are involved in the pathology of numerous diseases including cardiovascular diseases and are proposed as potential biomarkers of cardiovascular health that could be more effective compared to traditional clinical biomarkers. The aim of this study was to determine the sphingolipid content in the erythrocyte membrane of Libyan migrant and Serbian resident women. In addition, to examine if sphingolipid levels could be used as a novel indicator of cardiovascular risk, we evaluated possible correlations with some well-established biomarkers of cardiovascular health. Materials and Methods : A total of 13 Libyan and 15 Serbian healthy women participated in the study. The high-performance version thin-layer chromatography (HPTLC) using the image analysis tool JustTLC was applied for quantification of erythrocytes' sphingolipids. Results : Lower mean values of erythrocytes' sphingolipids and cholesterol concentrations were found in the group of Libyan emigrants compared to Serbian resident women. Besides, in this group of apparently healthy women ( n  = 28), the sphingolipid content of erythrocytes was inversely related to the Omega-3 index ( r =-0.492, p  = 0.008) and directly linked to vitamin D status ( r  = 0.433, p  = 0.021) and membrane cholesterol levels ( r  = 0.474, p  = 0.011). Conclusion : The erythrocytes' sphingolipid levels should be measured/assessed as an additional biomarker of CV health, by applying a simple and routine method. Still, further investigation in a larger population-specific context is warranted.
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فهرسة مساهمة: Keywords: Cardiovascular health; Libyan women; Omega-3 index; membrane cholesterol; sphingolipids; vitamin D
المشرفين على المادة: 0 (Sphingolipids)
0 (Biomarkers)
97C5T2UQ7J (Cholesterol)
تواريخ الأحداث: Date Created: 20231007 Date Completed: 20231101 Latest Revision: 20231101
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10561568
DOI: 10.1080/19932820.2023.2264568
PMID: 37804002
قاعدة البيانات: MEDLINE
الوصف
تدمد:1819-6357
DOI:10.1080/19932820.2023.2264568