دورية أكاديمية
أعرض في EDS

Factor V Leiden, estrogen, and multimorbidity association with venous thromboembolism in a British-South Asian cohort.

التفاصيل البيبلوغرافية
العنوان: Factor V Leiden, estrogen, and multimorbidity association with venous thromboembolism in a British-South Asian cohort.
المؤلفون: Magavern EF; William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK., Smedley D; William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK., Caulfield MJ; William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
مؤلفون مشاركون: Genes & Health Research Team
المصدر: IScience [iScience] 2023 Sep 01; Vol. 26 (10), pp. 107795. Date of Electronic Publication: 2023 Sep 01 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Multimorbidity, estrogen use, and Factor V Leiden (FVL) are known independent risk factors for venous thromboembolism (VTE). This cross-sectional analysis of women in the Genes & Health British-South Asian cohort (N 20,048) linked the F5 SNP rs6025 with estrogen prescribing data and VTE events. Multivariable logistic regression was used to test the association between estrogen use, FVL, common medical co-morbidities, and VTE. Estrogens were prescribed to 30% of women. 3% of participants were FVL carriers. 439 participants had a VTE event (2.2%), and VTE prevalence increased with obesity, hypertension, dyslipidemia, chronic kidney disease, estrogen use, and in the presence of FVL. One medical condition above was independently associated with VTE with an OR 1.6 (CI 1.2-2.0, p 0.001); two medical conditions OR 2.7 (CI 2.0-3.7, p < 0.001); three OR 5.3 (CI 3.8-7.4, p < 0.001); four OR 8.1 (CI 4.9-13.0, p < 0.001). Multimorbidity and FVL compound risk of VTE with estrogen use.
Competing Interests: The authors declare no conflicts of interest.
(© 2023 The Author(s).)
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Keywords: Cardiovascular medicine; Clinical endocrinology; Public health
تواريخ الأحداث: Date Created: 20231009 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10550715
DOI: 10.1016/j.isci.2023.107795
PMID: 37810217
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2023.107795